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Head and Neck Pathology Mar 2013Fibro-osseous lesions of the maxillofacial bones should be classified based on their radiographic growth pattern. This method can simplify this category of lesions,... (Review)
Review
Fibro-osseous lesions of the maxillofacial bones should be classified based on their radiographic growth pattern. This method can simplify this category of lesions, which have considerable overlapping histologic features. These neoplasms can be grouped into three categories: (a) fibrous dysplasia; (b) ossifying fibroma; (c) and osseous dysplasia. Important lesions in the differential diagnosis are osteoblastoma and giant cell reparative granuloma.
Topics: Bone Diseases; Facial Bones; Fibroma, Ossifying; Fibrous Dysplasia of Bone; Humans; Maxilla; Osteoma
PubMed: 23459840
DOI: 10.1007/s12105-013-0430-7 -
Dentistry Journal Jun 2022Mineralized lesions of the jaws are often found incidentally on radiographs and computed tomography. Most of them are benign, and only a few rare cases are associated... (Review)
Review
BACKGROUND
Mineralized lesions of the jaws are often found incidentally on radiographs and computed tomography. Most of them are benign, and only a few rare cases are associated with malignant transformation. However, there is little clinical data on successful rehabilitation with implants in patients with mineralized lesions. This narrative review aimed to study the efficiency and safety of dental implantation in the area of hyperdense lesions.
MATERIALS AND METHODS
A PubMed, Google Scholar, and Science Direct database search was carried out with keywords and manually.
RESULTS
The literature exploration identified 323 articles; only 19 of them matched the search criteria and reported cases about dental implantation in the lesion area. It has been shown that in 84.2% of described cases, dental implantation was successful: in the osteoid osteoma, odontoma, cementoblastoma, idiopathic osteosclerosis, and condensing osteitis areas dental implantation was performed without any complications. The possibility of lesion recurrence and implant failure limited the use of dental implants in the area of osteoblastoma and cemento-osseous dysplasia. Although most cases of dental implantation in hyperdense jaw lesions were successful and were not accompanied by complications, further research is needed.
PubMed: 35735649
DOI: 10.3390/dj10060107 -
Journal of Maxillofacial and Oral... Sep 2013Benign osteoblastoma is a rare tumor of bone representing less than 1% of all tumors of the maxillofacial region. There is a slight predilection for the mandible. More... (Review)
Review
BACKGROUND
Benign osteoblastoma is a rare tumor of bone representing less than 1% of all tumors of the maxillofacial region. There is a slight predilection for the mandible. More frequent sites for this tumor are the vertebral column, sacrum, long bones, and calvarium. A small predilection in males exists. The age of occurrence ranges from 5 to 37 years, with an average of 16.5. Clinically, patients have pain and swelling. The tumor contains a well-vascularized, osteoblastic connective tissue stroma. Osteoclasts may also be present. Osteoid with varying degrees of calcification, as well as immature bone, is noted.
CASE REPORT
Very few cases of osteoblastomas occurring in the jaws have been reported in the literature. This is one such a rare case report of OB occurring in a 45 year old female patient with a swelling in right lower back region since 5 years.
SUMMARY AND CONCLUSION
Osteoblastoma has to be differentiated from other bone lesions for correct diagnosis. Many bone producing lesions possess some overlapping clinical, radiographic or histopathological findings similar to osteoblastoma. Understanding and correlating all these features is of utmost importance. This helps in correctly diagnosing and helps in adequate management of this rare entity, giving a good prognosis.
PubMed: 24431864
DOI: 10.1007/s12663-011-0263-4 -
Orthopaedics & Traumatology, Surgery &... Oct 2010We report the case of an osteoblastoma of the hamate bone that was successfully treated by curettage. This tumor is very rare in a carpal bone and only nine cases have...
We report the case of an osteoblastoma of the hamate bone that was successfully treated by curettage. This tumor is very rare in a carpal bone and only nine cases have been reported in the literature. Pathological examination is mandatory before treatment due to the lack of distinctive clinical and radiological features. Osteoblastomas are benign, but potentially aggressive bone tumors. Treatment of the lesion may either be a conservative "intralesional resection" or radical "wide en bloc resection". The latter option, which has non-negligible functional consequences in the wrist, should be reserved for recurrence after curettage but may also be considered a primary immediate alternative for aggressive forms.
Topics: Adult; Biopsy; Bone Cysts; Bone Neoplasms; Curettage; Delayed Diagnosis; Hamate Bone; Humans; Magnetic Resonance Imaging; Male; Osteoblastoma; Osteolysis; Radiography
PubMed: 20692218
DOI: 10.1016/j.otsr.2010.02.014 -
Insights Into Imaging Jun 2020Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal... (Review)
Review
Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal pathology can help the radiologist formulate a comprehensive differential diagnosis. This article focuses on the spectrum of extradural spinal tumors, accounting for the majority of primary spinal tumors, by comparing the epidemiology, pathophysiology, clinical presentation, and characteristic imaging appearance of these lesions. The discussion includes the commonly encountered benign lesions, such as vertebral venous vascular malformation and enostosis, as well as malignant lesions including metastases and lymphoma. The article also includes other less-encountered primary spinal tumors such as plasmacytoma, osteoid osteoma, osteoblastoma, giant cell tumor, eosinophilic granuloma, chordoma, chondrosarcoma, osteosarcoma, Ewing's sarcoma, and angiosarcoma. Familiarity with the characteristic imaging features can help the radiologist reach an accurate diagnosis and obviate the need for unnecessary invasive procedures such as biopsy and surgery.
PubMed: 32601958
DOI: 10.1186/s13244-020-00883-6 -
Head and Neck Pathology Dec 2012
Topics: Bone Neoplasms; Humans; Male; Maxillary Sinus Neoplasms; Osteoblastoma; Young Adult
PubMed: 22528828
DOI: 10.1007/s12105-012-0356-5 -
BMC Musculoskeletal Disorders Apr 2020To analyze the features of CT, MRI and PET/CT and their diagnostic value for spinal osteoblastomas (OBs).
BACKGROUND
To analyze the features of CT, MRI and PET/CT and their diagnostic value for spinal osteoblastomas (OBs).
METHODS
The radiological and clinical data of 21 patients with histopathologically-confirmed spinal OBs were analyzed retrospectively.
RESULTS
Sixteen of the 21 cases were benign and 5 were aggressive OBs. Tumors were located in the lumbar (n = 11), cervical (n = 4), thoracic (n = 5), and sacral (n = 1) spinal regions. Nineteen cases were centered in the posterior elements of the spine, 13 of which extended into the vertebral body. Punctate or nodular calcifications were found in all cases on CT with a complete sclerotic rim (n = 12) or incomplete sclerotic rim (n = 8). The flare phenomenon (indicative of surrounding tissue inflammation) was found in 17/21 cases on CT, thin in 11 cases and thick in 6 cases, and in 19/19 cases on MRI, thin in 1 case and thick in 18 cases. On F-FDG PET/CT, all cases (8/8) were metabolically active with the SUVmax of 12.3-16.0; the flare sign was observed in 8 cases, including 7 cases of hypometabolism and 1 case of coexistence of hypermetabolism and hypometabolism. Based on CT, 3, 12, and 6 cases were classified as Enneking stage 1, 2 and 3, respectively. Of 19 cases with MRI, 1 and 18 cases were classified as Enneking stage 2 and 3, respectively.
CONCLUSIONS
Spinal OB has multiple unique characteristic radiological features. Although a larger sample size is needed, combining CT, MRI and PET may be beneficial to optimize preoperative diagnosis and care of patients with OBs.
Topics: Adolescent; Adult; Algorithms; Child; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Osteoblastoma; Positron-Emission Tomography; Retrospective Studies; Spinal Neoplasms; Tomography, X-Ray Computed; Young Adult
PubMed: 32290828
DOI: 10.1186/s12891-020-03252-y -
Journal of Bone Oncology Jun 2015Benign tumours of the bone are not cancerous and would not metastasise to other regions of the body. However, they can occur in any part of the skeleton, and can still... (Review)
Review
Benign tumours of the bone are not cancerous and would not metastasise to other regions of the body. However, they can occur in any part of the skeleton, and can still be dangerous as they may grow and compress healthy bone tissue. There are several types of benign tumours that can be classified by the type of matrix that the tumour cells produce; such as bone, cartilage, fibrous tissue, fat or blood vessel. Overall, 8 different types can be distinguished: osteochondroma, osteoma, osteoid osteoma, osteoblastoma, giant cell tumour, aneurysmal bone cyst, fibrous dysplasia and enchondroma. The incidence of benign bone tumours varies depending on the type. However, they most commonly arise in people less than 30 years old, often triggered by the hormones that stimulate normal growth. The most common type is osteochondroma. This review discusses the different types of common benign tumours of the bone based on information accumulated from published literature.
PubMed: 26579486
DOI: 10.1016/j.jbo.2015.02.001 -
Brain & Spine 2022•Metaplastic meningiomas are rare entities, and intracranial osseous subtype are even more rare.•Gross total resection is considered the best treatment... (Review)
Review
•Metaplastic meningiomas are rare entities, and intracranial osseous subtype are even more rare.•Gross total resection is considered the best treatment choice.•Differential diagnosis is mandatory, including osteoma, osteoblastoma, and calcified giant aneurysms.•This rare entity must be considered in a global approach and tailored surgical technique.
PubMed: 36248170
DOI: 10.1016/j.bas.2022.101189 -
Nature Communications Jun 2018The transcription factor FOS has long been implicated in the pathogenesis of bone tumours, following the discovery that the viral homologue, v-fos, caused osteosarcoma...
The transcription factor FOS has long been implicated in the pathogenesis of bone tumours, following the discovery that the viral homologue, v-fos, caused osteosarcoma in laboratory mice. However, mutations of FOS have not been found in human bone-forming tumours. Here, we report recurrent rearrangement of FOS and its paralogue, FOSB, in the most common benign tumours of bone, osteoblastoma and osteoid osteoma. Combining whole-genome DNA and RNA sequences, we find rearrangement of FOS in five tumours and of FOSB in one tumour. Extending our findings into a cohort of 55 cases, using FISH and immunohistochemistry, provide evidence of ubiquitous mutation of FOS or FOSB in osteoblastoma and osteoid osteoma. Overall, our findings reveal a human bone tumour defined by mutations of FOS and FOSB.
Topics: Adolescent; Adult; Amino Acid Sequence; Animals; Base Sequence; Bone Neoplasms; Child; Child, Preschool; Female; Gene Rearrangement; Humans; Male; Mice; Middle Aged; Mutation; Osteoblastoma; Proto-Oncogene Proteins c-fos; Whole Genome Sequencing; Young Adult
PubMed: 29858576
DOI: 10.1038/s41467-018-04530-z