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Archives of Pathology & Laboratory... Jul 2019
Topics: Humans; Medical Overuse; Pathologists; Radiologists; Thyroid Neoplasms
PubMed: 31225996
DOI: 10.5858/arpa.2019-0146-LE -
Archives of Pathology & Laboratory... Jul 2019
Topics: Humans; Medical Overuse; Pathologists; Radiologists; Thyroid Neoplasms
PubMed: 31225992
DOI: 10.5858/arpa.2019-0103-LE -
Archives of Pathology & Laboratory... Apr 2019
Topics: Breast Neoplasms; Humans; Medical Oncology; Pathologists; Receptor, ErbB-2; United States
PubMed: 30605367
DOI: 10.5858/arpa.2018-0906-LE -
Pathologica Oct 2023Even if the SARS-CoV-2 pandemic has been declared over, several risks and clinical problems remain to be faced, including long-COVID sequelae and possible outbreaks of... (Review)
Review
Even if the SARS-CoV-2 pandemic has been declared over, several risks and clinical problems remain to be faced, including long-COVID sequelae and possible outbreaks of pathogenic variants. Intense research on COVID-19 has provided in these few years a striking amount of data covering different fields and disciplines, which can help to provide a knowledge shield against new potential infective spreads, and may also potentially be applied to other fields of medicine, including oncology and neurology. Nevertheless, areas of uncertainty still remain regarding the pathogenic mechanisms that subtend the multifaceted manifestations of the disease. To better clarify the pathogenesis of the disease, a systematic multidisciplinary evaluation of the many mechanisms involved in COVID-19 is mandatory, including clinical, physiological, radiological, immunological and pathological studies. In COVID-19 syndrome the pathological studies have been mainly performed on autopsy cases, and only a few studies are available on biopsies. Nevertheless, these studies have provided relevant information that can substantially contribute to decipher the complex scenario characterizing the different forms of COVID-19 and long-COVID-19. In this review the data provided by pathological investigations are recapitulated and discussed, in the light of different hypothesis and data provided by clinical, physiological and immunological data.
Topics: Humans; COVID-19; Pathologists; Post-Acute COVID-19 Syndrome; SARS-CoV-2; Biology
PubMed: 38054899
DOI: 10.32074/1591-951X-954 -
Journal of Speech, Language, and... Feb 2021Purpose The purpose of this study is to familiarize speech-language-pathologists with the current state of the science regarding medialization laryngoplasty in the... (Review)
Review
Purpose The purpose of this study is to familiarize speech-language-pathologists with the current state of the science regarding medialization laryngoplasty in the treatment of voice disorders, with emphasis on current evidence-based practice, voice outcomes, and future directions for research. Method A literature review was performed in PubMed and Embase using the keywords and or . Articles published between 2010 and 2020 were reviewed for data about clinical applications, technical approach, voice-related outcomes, and basic science or clinical innovations with the potential to improve patient care. A synthesis of data was performed from articles meeting the outlined search criteria. Conclusions As key members in the multidisciplinary care of voice disorders, speech-language pathologists need to be informed of current research in medialization laryngoplasty, a procedure commonly used for patients with glottic insufficiency. Advances in anesthetic technique, office-based procedures, and the development of materials with increased bio-tolerability over the past decade have led to innovations in treatment and improved patient outcomes. Recent applications of computational and bioengineering approaches have the potential to provide new directions in the refinement of currently available techniques and the improvement of patient-based treatment outcomes.
Topics: Humans; Laryngoplasty; Pathologists; Retrospective Studies; Speech; Treatment Outcome; Vocal Cord Paralysis; Vocal Cords
PubMed: 33524276
DOI: 10.1044/2020_JSLHR-20-00344 -
Cancer Cytopathology Dec 2020
Topics: COVID-19; Humans; Interdisciplinary Communication; Interpersonal Relations; Pandemics; Pathologists; Pathology, Clinical; Physical Distancing; Referral and Consultation; SARS-CoV-2; Telepathology
PubMed: 33125190
DOI: 10.1002/cncy.22379 -
Nature Communications Jan 2024Highly multiplexed protein imaging is emerging as a potent technique for analyzing protein distribution within cells and tissues in their native context. However,...
Highly multiplexed protein imaging is emerging as a potent technique for analyzing protein distribution within cells and tissues in their native context. However, existing cell annotation methods utilizing high-plex spatial proteomics data are resource intensive and necessitate iterative expert input, thereby constraining their scalability and practicality for extensive datasets. We introduce MAPS (Machine learning for Analysis of Proteomics in Spatial biology), a machine learning approach facilitating rapid and precise cell type identification with human-level accuracy from spatial proteomics data. Validated on multiple in-house and publicly available MIBI and CODEX datasets, MAPS outperforms current annotation techniques in terms of speed and accuracy, achieving pathologist-level precision even for typically challenging cell types, including tumor cells of immune origin. By democratizing rapidly deployable and scalable machine learning annotation, MAPS holds significant potential to expedite advances in tissue biology and disease comprehension.
Topics: Humans; Pathologists; Machine Learning; Diagnostic Imaging; Proteomics
PubMed: 38167832
DOI: 10.1038/s41467-023-44188-w -
Archives of Pathology & Laboratory... May 2017
Topics: Artificial Intelligence; Deep Learning; Forecasting; Humans; Pathologists
PubMed: 28447905
DOI: 10.5858/arpa.2016-0593-ED -
Virchows Archiv : An International... Nov 2020The vast increase of technical, diagnostic, and treatment possibilities and deepened understanding of molecular biology has revolutionized diagnosis and treatment of...
The vast increase of technical, diagnostic, and treatment possibilities and deepened understanding of molecular biology has revolutionized diagnosis and treatment of cancer and thus has great impact on pathology. Different professionals are responsible for proper evaluation of the results and their translating into an accurate diagnosis and appropriate treatment. Next to expertise, a close interaction between clinical molecular biologists, pathologists, and oncologists is required; it is crucial that these professionals speak "the same language." Key to this is communication skills and creating possibilities for collaboration in a meaningful context. Here, we present an interprofessional, educational workshop model and we describe the parameters that contribute to effective learning by specialists.
Topics: Attitude of Health Personnel; Clinical Competence; Congresses as Topic; Cooperative Behavior; Education, Medical, Continuing; Humans; Inservice Training; Interprofessional Relations; Learning; Oncologists; Pathologists; Specialization; Staff Development
PubMed: 32270299
DOI: 10.1007/s00428-020-02803-x -
Indian Journal of Pathology &... May 2022Autoimmune encephalitis is a group of non-infectious immune-mediated inflammatory disorders manifesting with epilepsy and encephalitis syndromes that are associated with... (Review)
Review
Autoimmune encephalitis is a group of non-infectious immune-mediated inflammatory disorders manifesting with epilepsy and encephalitis syndromes that are associated with autoantibodies in the serum and/or cerebrospinal fluid (CSF). Pathogenic autoantibodies have been discovered against intracellular onconeural antigens, surface neuronal, or synaptic antigens with distinctive pathogenesis that underlie differences in response to immunotherapy. The onconeural antigens incite cytotoxic T-cell-mediated neuronal destruction, whereas surface antigens trigger direct damage by autoantibodies via complement mediated pathways, and hence respond well to immunomodulatory therapy, in contrast to poor response in the former. Neuroimaging, electroencephalogram, and CSF findings being non-specific, detection of autoantibodies is essential for a confirmatory diagnosis. Detection methods available include tissue-based assay, cell-based assays, immunoblot, cell culture, flow cytometry, and enzyme-linked immunosorbent assays. In this review, we discuss the various testing modalities available for onconeural and cell surface antibodies, their sensitivity and specificity and the emerging role of the pathologist in the diagnosis of autoimmune encephalitis. Early diagnosis is crucial for instituting treatment and preventing morbidity and mortality.
Topics: Autoantibodies; Encephalitis; Hashimoto Disease; Humans; Pathologists
PubMed: 35562150
DOI: 10.4103/ijpm.ijpm_41_22