-
Psychiatry and Clinical Neurosciences Jun 2000A female narcoleptic patient with persistent auditory hallucinations and delusion is reported. These psychotic symptoms appeared before the diagnosis of narcolepsy and...
A female narcoleptic patient with persistent auditory hallucinations and delusion is reported. These psychotic symptoms appeared before the diagnosis of narcolepsy and before the use of pemoline and clomipramine. On admission to the Department of Neuropsychiatry at the Kurume University school of Medicine, the patient's auditory hallucinations were almost the same as the previous hallucinations. The patient's delusional state improved smoothly after haloperidol administration. After that, the patient related well socially. The persistent auditory hallucinations were correlated with rapid eye movement sleep symptoms during her disease process so that we concluded that her persistent auditory hallucinations and delusion of observation were due to narcoleptic symptoms.
Topics: Delusions; Diagnosis, Differential; Female; Hallucinations; Haloperidol; Humans; Middle Aged; Narcolepsy; Polysomnography; Sleep Stages
PubMed: 11186095
DOI: 10.1046/j.1440-1819.2000.00696.x -
The American Journal of Psychiatry Jan 2009While there has been considerable concern over possible adverse effects of psychostimulants on brain development, this issue has not been examined in a prospective...
OBJECTIVE
While there has been considerable concern over possible adverse effects of psychostimulants on brain development, this issue has not been examined in a prospective study. The authors sought to determine prospectively whether psychostimulant treatment for attention deficit hyperactivity disorder (ADHD) was associated with differences in the development of the cerebral cortex during adolescence.
METHOD
Change in cortical thickness was estimated from two neuroanatomic MRI scans in 43 youths with ADHD. The mean age at the first scan was 12.5 years, and at the second scan, 16.4 years. Nineteen patients not treated with psychostimulants between the scans were compared with an age-matched group of 24 patients who were treated with psychostimulants. Further comparison was made against a template derived from 620 scans of 294 typically developing youths without ADHD.
RESULTS
Adolescents taking psychostimulants differed from those not taking psychostimulants in the rate of change of the cortical thickness in the right motor strip, the left middle/inferior frontal gyrus, and the right parieto-occipital region. The group difference was due to more rapid cortical thinning in the group not taking psychostimulants (mean cortical thinning of 0.16 mm/year [SD=0.17], compared with 0.03 mm/year [SD=0.11] in the group taking psychostimulants). Comparison against the typically developing cohort without ADHD showed that cortical thinning in the group not taking psychostimulants was in excess of age-appropriate rates. The treatment groups did not differ in clinical outcome, however.
CONCLUSIONS
These findings show no evidence that psychostimulants were associated with slowing of overall growth of the cortical mantle.
Topics: Adolescent; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cerebral Cortex; Child; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Methylphenidate; Pemoline; Young Adult
PubMed: 18794206
DOI: 10.1176/appi.ajp.2008.08050781 -
Psychopathology 2005
Topics: Adult; Animals; Central Nervous System Stimulants; Delusions; Humans; Male; Parasites; Pemoline; Substance-Related Disorders
PubMed: 15855835
DOI: 10.1159/000085352 -
Journal of Psychiatry & Neuroscience :... Jan 1997
Topics: Central Nervous System Stimulants; Depressive Disorder; Dopamine; Dose-Response Relationship, Drug; Female; Humans; Norepinephrine; Pemoline; Remission, Spontaneous
PubMed: 9002395
DOI: No ID Found -
The Journal of Physiology May 1978
Topics: Benzodiazepines; Caffeine; Color Perception; Inhibition, Psychological; Parasympatholytics; Pemoline
PubMed: 671332
DOI: No ID Found