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Maturitas Oct 2023In this study we examined the associations between menopausal symptoms and work ability and health among a general population of Dutch female workers.
OBJECTIVE
In this study we examined the associations between menopausal symptoms and work ability and health among a general population of Dutch female workers.
STUDY DESIGN
This nationwide cross-sectional study was a follow-up of the Netherlands Working Conditions Survey 2020. In 2021, 4010 Dutch female employees aged 40-67 years completed an online survey on a variety of topics, including menopausal symptoms, work ability and health.
METHODS
Linear and logistic regression analyses were performed to investigate the association between the degree of menopausal symptoms with work ability, self-rated health and emotional exhaustion, after adjustment for potential confounders.
RESULTS
Almost one-fifth of participants were in the perimenopause (n = 743). Of these women, 80 % experienced menopausal symptoms: 27.5 % 'often' and 52.5 % 'sometimes'. Experiencing menopausal symptoms was associated with lower work ability, poorer self-rated health, and more emotional exhaustion. These associations were most pronounced among perimenopausal women 'often' experiencing symptoms.
CONCLUSIONS
Menopausal symptoms threaten the sustainable employability of female workers. Interventions and guidelines are needed to support women, employers and (occupational) health professionals.
Topics: Female; Humans; Perimenopause; Menopause; Cross-Sectional Studies; Work Capacity Evaluation; Surveys and Questionnaires
PubMed: 37393659
DOI: 10.1016/j.maturitas.2023.107793 -
Journal of Traditional Chinese Medicine... Jun 2023To examine, dissect, and understand the molecular mechanisms and combinatorial effects of Zuogui (, ZGP) and Yougui pills (, YGP) in 4-vinyl cyclohexene diepoxide...
OBJECTIVE
To examine, dissect, and understand the molecular mechanisms and combinatorial effects of Zuogui (, ZGP) and Yougui pills (, YGP) in 4-vinyl cyclohexene diepoxide (4-VCD)-induced Perimenopausal syndrome (PMS).
METHODS
Using the 4-VCD-induced PMS mouse model, uterine and ovary index were measured, and serum sex steroidal hormone levels were evaluated after treatment with ZGP, YGP, ZGP + YGP, estradiol valerate (EV), and Gengnian An (gengnianan, GNA). Histopathological examinations, ingredient-target network predictions, western blotting, and real-time quantitative polymerase chain reaction (RT-qPCR) analyses were performed to ascertain the possible pharmacological effects and molecular mechanisms of ZYP and YGP.
RESULTS
Treatment with ZGP and YGP remarkably improves estrous cyclicity and prevents pathological damage to the uterus. Also, altered sex hormones, including AMH, E2, FSH, LH, P, and T, were restored to normal levels after ZGP and YGP administration. Ingredient-target network analysis showed that the 5 ingredients common to the ZGP and YGP formula modulate 53 targets shared with PMS. Pathway-enrichment analysis further predicted that ZGY and YGP likely regulate of apoptosis and other essential pathways during PMS. In-vivo studies showed that ZGP and YGP suppress PMS modulating apoptosis through decreasing Caspase-3 and Bcl-2-associated X (Bax) levels and increasing B-cell lymphoma-2 (Bcl-2)/Bax and Bcl-2 levels. Importantly, ZGP + YGP treatment modulation effects were somewhat or significantly better compared to ZGP or YGP alone treatment.
CONCLUSION
ZGP and YGP represent novel anti-PMS agents whose effects involve restoring altered hormonal levels, protecting the uterus, and regulating apoptosis.
Topics: Female; Mice; Animals; Perimenopause; bcl-2-Associated X Protein; Drugs, Chinese Herbal; Gonadal Steroid Hormones; Apoptosis
PubMed: 37147748
DOI: 10.19852/j.cnki.jtcm.20220507.001 -
Journal de Gynecologie, Obstetrique Et... Dec 2011More and more perimenopausal and menopausal women seek an alternative to hysterectomy because they desire future pregnancy or wish to retain their uteri even if they... (Review)
Review
More and more perimenopausal and menopausal women seek an alternative to hysterectomy because they desire future pregnancy or wish to retain their uteri even if they have completed childbearing. Myomectomy may be an option. We can't know the evolution of leiomyomas. Hysteroscopic myomectomy is the treatment of submucous fibromas. Recurrence and subsequent surgery occurs in 16 to 21 % of cases. Intramural and subserousal myomas can be treated by myomectomy. Myomectomy should be performed laparoscopically because of shorter hospital stay, faster recovery and reduced postoperative pain. Second surgery is needed in 4-16 % of patients. If hysterectomy is performed, it should be by vaginal or laparoscopic route. There is no difference in perioperative morbidity between hysterectomy and myomectomy. Intra- and postoperative complications are similar between myomectomy and hysterectomy. Hysterectomy may be prefered if there is risk factor of malignancy or if the fibroma is discovered or has a rapid growth after menopause.
Topics: Disease Progression; Female; Fertility; Gynecologic Surgical Procedures; Humans; Leiomyoma; Perimenopause; Postmenopause; Postoperative Complications; Pregnancy; Uterine Neoplasms; Watchful Waiting
PubMed: 22056189
DOI: 10.1016/j.jgyn.2011.09.024 -
Scientific Reports Jun 2023This study tested progesterone for perimenopausal hot flush ± night sweat (vasomotor symptom, VMS) treatment. It was a double-blind, randomized trial of 300 mg... (Randomized Controlled Trial)
Randomized Controlled Trial
This study tested progesterone for perimenopausal hot flush ± night sweat (vasomotor symptom, VMS) treatment. It was a double-blind, randomized trial of 300 mg oral micronized progesterone@bedtime versus placebo for 3-months (m) after a 1-m untreated baseline during 2012/1-2017/4. We randomized untreated, non-depressed, screen- and baseline-eligible by VMS, perimenopausal women (with flow within 1-year), ages 35-58 (n = 189). Participants aged 50 (± SD = 4.6) were mostly White, educated, minimally overweight with 63% in late perimenopause; 93% participated remotely. The 1° outcome was 3rd-m VMS Score difference. Participants recorded VMS number and intensity (0-4 scale)/24 h on a VMS Calendar. Randomization required VMS (intensity 2-4/4) of sufficient frequency and/or ≥ 2/week night sweat awakenings. Baseline total VMS Score (SD) was 12.2 (11.3) without assignment difference. Third-m VMS Score did not differ by therapy (Rate Difference - 1.51). However, the 95% CI [- 3.97, 0.95] P = 0.222, did not exclude 3, a minimal clinically important difference. Women perceived progesterone caused decreased night sweats (P = 0.023) and improved sleep quality (P = 0.005); it decreased perimenopause-related life interference (P = 0.017) without increased depression. No serious adverse events occurred. Perimenopausal night sweats ± hot flushes are variable; this RCT was underpowered but could not exclude a minimal clinically important VMS benefit. Perceived night sweats and sleep quality significantly improved.
Topics: Female; Humans; Perimenopause; Progesterone; Sweat; Postmenopause; Hot Flashes; Canada
PubMed: 37277418
DOI: 10.1038/s41598-023-35826-w -
Medicine Aug 2016Limited information was focused on perimenopausal syndrome and mood disorders (depression and anxiety) in a specific population: perimenopausal women. We aimed to...
Limited information was focused on perimenopausal syndrome and mood disorders (depression and anxiety) in a specific population: perimenopausal women. We aimed to investigate the prevalence and severity of perimenopausal syndrome and mood disorders, and to analyze their relationships and risk factors in perimenopausal women in Shanghai, China.A cross-sectional study was performed on 1062 women aged 40 to 60 years from 3 communities. The general conditions questionnaire, Kupperman index, self-rating depression scale, and self-rating anxiety scale were used. A multivariable logistic regression analysis was performed to identify risk factors for perimenopausal syndrome and mood disorders.The prevalence of perimenopausal syndrome, depression and anxiety, which were primarily associated with mild symptoms, was 10.92%, 25.99%, and 12.62%, respectively. The differences in the prevalence and severity of perimenopausal syndrome, in the prevalence of depression, and in the severity of anxiety in different age groups were statistically significant (P < 0.001, P = 0.028, P = 0.003, P = 0.002, respectively). The relationships between perimenopausal syndrome and mood disorders were strong and positive (P < 0.001). It was found that age, employment status, personality characteristics, menstruation, and constipation were risk factors for perimenopausal syndrome, but monthly household income was a protective factor. Also, higher income and better medical insurance were beneficial to depression. However, disharmonious family relationships, irregular menstruation, constipation, and severity of perimenopausal syndrome were harmful to depression. For anxiety, attitudes to children status, cesarean section times, and constipation were risk factors.We concluded that perimenopausal syndrome and mood disorders are common in perimenopausal women in Shanghai, whose associations are strong and positive. Many risk factors are associated with and shared between perimenopausal syndrome and mood disorders. Therefore, appropriate management of perimenopause is needed to alleviate the conditions.
Topics: Adult; Anxiety; Body Mass Index; China; Cross-Sectional Studies; Depression; Female; Humans; Middle Aged; Mood Disorders; Perimenopause; Prevalence; Risk Factors; Surveys and Questionnaires; Syndrome
PubMed: 27512863
DOI: 10.1097/MD.0000000000004466 -
Nutrients Apr 2022The transition from premenopause to postmenopause is associated with the development of multiple elements of Metabolic Syndrome (MetS) [...].
The transition from premenopause to postmenopause is associated with the development of multiple elements of Metabolic Syndrome (MetS) [...].
Topics: Diet; Diet, Mediterranean; Female; Humans; Isoflavones; Menopause; Metabolic Syndrome; Perimenopause
PubMed: 35458114
DOI: 10.3390/nu14081550 -
Menopause (New York, N.Y.) Oct 2022The aims of this study were to investigate trends in bone mineral density (BMD) loss and related factors in early postmenopausal women in Japan, identify risk factors...
OBJECTIVE
The aims of this study were to investigate trends in bone mineral density (BMD) loss and related factors in early postmenopausal women in Japan, identify risk factors for future osteoporosis, and predict osteoporosis before it occurs.
METHODS
The study population consisted of women who were 50 to 54 years old at the time of the survey in 2002 or 2006. The study included a questionnaire and physical measurement findings (BMD, height, body weight [WT], body mass index [BMI], and handgrip strength). One hundred sixty-seven women continued to participate in the study and had BMD measurements at the 9- or 10-year follow-up of the Japanese Population-based Osteoporosis study. Statistical analyses were performed using Pearson correlation to examine each factor of physical measurement and BMD for lumbar spine (LS) and femoral neck (FN). The receiver operating characteristic curve of this data was also predictive of osteoporosis in 2011 for 2002 data; BMD at the age of 50 to 54 years was then used to predict the likelihood of being diagnosed with osteoporosis 9 and 10 years later.
RESULTS
At the baseline in 2002 and 2006, WT, BMI, height, and handgrip strength were positively correlated with BMD. The optimal cutoff values for BMD in 2006 to predict osteoporosis in 2016 were LS less than 0.834 g/cm 2 and FN less than 0.702 g/cm 2 . These data were also predictive of osteoporosis in 2011 for 2002 data; applying this to the 2002 data, LS/FN had a sensitivity of 92%/100%, a specificity of 87%/81%, a positive predictive value of 55%/48%, and a negative predictive value of 98%/100%. The larger WT and BMI also resulted in a greater decrease in BMD of FN after 9 or 10 years.
CONCLUSIONS
We have identified a cutoff value for BMD to predict future osteoporosis in menopausal women and found a negative correlation between WT and BMI in menopausal women and changes in BMD of the FN over the next 10 years.
Topics: Absorptiometry, Photon; Body Weight; Bone Density; Female; Femur Neck; Hand Strength; Humans; Japan; Lumbar Vertebrae; Middle Aged; Osteoporosis; Osteoporosis, Postmenopausal; Perimenopause; Risk Factors
PubMed: 35969496
DOI: 10.1097/GME.0000000000002034 -
BMC Psychiatry Feb 2023Women in perimenopause are vulnerable to depressive symptoms, and physical activity was reported to be a potential protective factor. The trajectories of physical...
BACKGROUND
Women in perimenopause are vulnerable to depressive symptoms, and physical activity was reported to be a potential protective factor. The trajectories of physical activity and depressive symptoms over time and their longitudinal relationships in Chinese perimenopausal women have not been explored yet, leaving a research gap hindering us from better understanding and managing perimenopause depressive symptoms.
METHODS
A multi-center prospective longitudinal study was conducted in four cities in Sichuan Province, China. Depressive symptoms and physical activity in perimenopausal women were collected in March 2019, June 2019, September 2019, and December 2019, respectively. Multivariable linear regression by generalized estimation equation was used to identify the relevant factors associated with depressive symptoms and physical activity. A four-wave autoregressive and cross-lagged panel model was performed to explore their longitudinal relationships.
RESULTS
A total of 1875 women who completed the four-wave data collection were included in the data analysis. Depressive symptoms exacerbated over time and were associated with women's age, monthly income, marital status, chronic disease, and negative life events. Physical activity decreased over time and was associated with educational background and monthly income. According to the cross-lagged panel model, perimenopausal women with more severe depressive symptoms tended to be less physically active, and similarly, perimenopausal women with less physical activity were more prone to report more severe depressive symptoms.
CONCLUSION
The cross-lagged panel model disclosed longitudinal bidirectional relationships between depressive symptoms and physical activity in perimenopausal women. Appropriate physical activity should be recommended for perimenopausal women to improve their mental well-being. Tailored physical activity duration and maintenance measures should be proposed based on different sociodemographic statuses.
Topics: Female; Humans; Perimenopause; Depression; Longitudinal Studies; Prospective Studies; Independent Living; Exercise; Surveys and Questionnaires
PubMed: 36750920
DOI: 10.1186/s12888-023-04591-5 -
Menopause (New York, N.Y.) Dec 2021This study investigated whether (1) cognitive functions change after the transition from the perimenopausal to the postmenopausal stage, (2) cognitive functions and...
OBJECTIVE
This study investigated whether (1) cognitive functions change after the transition from the perimenopausal to the postmenopausal stage, (2) cognitive functions and walking are associated in middle-aged women, and (3) cognitive functions assessed in perimenopause are associated with walking after reaching the postmenopause or vice versa.
METHODS
In total, 342 women, categorized as early (n = 158) or late perimenopausal (n = 184), were included in the study and followed up until postmenopausal. Psychomotor speed, executive functions related to set-shifting and updating, working memory, and visual memory were assessed. Walking was assessed with walking speed, walking distance, and dual-task cost in walking speed. Data was analyzed using the paired-samples t test, Wilcoxon signed rank test, multiple linear regression analysis, and structural equation modeling.
RESULTS
We found small but significant improvements in psychomotor speed (P = 0.01) and working memory (P < 0.001) among early perimenopausal and in psychomotor speed (P = 0.001), set-shifting (P = 0.02), visual memory (P = 0.002), and working memory (P < 0.001) among late perimenopausal women after the transition from peri- to postmenopause. Walking speed (β = 0.264, P = 0.001) and dual-task cost (β = 0.160, P = 0.03) were associated with updating, and walking distance was associated with updating and set-shifting (β = 0.198, P = 0.02, β=-0.178 P = 0.04 respectively) among the late perimenopausal women. We found no longitudinal associations between cognitive functions and walking.
CONCLUSION
Cognitive performance remained unchanged or improved after reaching postmenopause. Cognitive functions and walking were associated during the late perimenopause, but the association depended on the cognitive process and nature of the physical task. Cognitive performance was not associated with walking after reaching postmenopause or vice versa.
Topics: Cognition; Executive Function; Female; Humans; Memory, Short-Term; Middle Aged; Perimenopause; Walking
PubMed: 34930867
DOI: 10.1097/GME.0000000000001896 -
Ginekologia Polska 2021The objective of the study was to assess correlations between practising sports at an elite level at a young age, and the current physical activity level, selected...
OBJECTIVES
The objective of the study was to assess correlations between practising sports at an elite level at a young age, and the current physical activity level, selected sociometric features and the severity of menopausal symptoms in women during perimenopause, which will contribute to the knowledge about undertaking sports activity.
MATERIAL AND METHODS
The study involved a total of 334 females aged 45-65. They were purposefully assigned to both a study and control group. The study group included 148 women - former elite athletes qualified based on the presumed criteria. The control group consisted of 154 women who did not meet the criterion of practising sports activity earlier in life. In order to conduct the study, we applied the method of a diagnostic survey. The outcome measure was a survey questionnaire and contained questions concerning sociometric features, some elements of gynaecological history, and physical activity undertaken in the past. The second part used the International Physical Activity Questionnaire (IPAQ) and Blatt-Kupperman Menopausal Index.
RESULTS
The groups were homogenous in terms of age and BMI. The former athletes most frequently used to practise athletics, team games and swimming. Both groups displayed no differences regarding the age at menarche, the onset of sexual activity, and the presence and regularity of menstruation. The former athletes had fewer children compared to the controls. They manifested a higher level of physical activity in particular areas and intensity categories. The comparison between the two groups did not show statistically significant differences in the severity of menopausal symptoms.
CONCLUSIONS
Sports training in the past differentiates selected sociometric features such as economic activity and a numerous pregnancies and births. Sports training in the past has an impact on the current level of physical activity - the females who used to train present its higher level. Sports training in the past does not differentiate the severity of menopausal symptoms.
Topics: Aged; Child; Exercise; Female; Humans; Menarche; Menopause; Middle Aged; Perimenopause; Pregnancy; Sports
PubMed: 33751508
DOI: 10.5603/GP.a2021.0028