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Antimicrobial Agents and Chemotherapy Jul 1975The absorption of orally administered pivampicillin was studied in nine postoperative patients and compared with that of intravenously administered ampicillin. The... (Comparative Study)
Comparative Study
The absorption of orally administered pivampicillin was studied in nine postoperative patients and compared with that of intravenously administered ampicillin. The absorption of pivampicillin was calculated on the basis of comparison of the areas under the serum concentration curves for both modes of administration. After an oral dose of 700 mg the absorption ranged from 40 to 95% (mean, 60%).
Topics: Absorption; Adult; Aged; Ampicillin; Female; Humans; Kinetics; Male; Middle Aged; Pivampicillin; Postoperative Care; Surgical Wound Infection; Time Factors
PubMed: 1164005
DOI: 10.1128/AAC.8.1.11 -
BMJ Case Reports Sep 2015Good's syndrome is a rare primary immunodeficiency associated with adult thymoma. Complications are mainly autoimmune manifestations and recurrent infections with...
Good's syndrome is a rare primary immunodeficiency associated with adult thymoma. Complications are mainly autoimmune manifestations and recurrent infections with encapsulated bacteria. Only one possible case of combined granulomatous-lymphocytic interstitial lung disease (GL-ILD) and Good's syndrome have been described earlier, but the patient died at the time of diagnosis. This is the first case of GL-ILD in Good's syndrome with a successful outcome. We present a case of a 43-year-old man with GL-ILD, who suffered from recurrent infections of Haemophilus influenzae and Pneumocystis jirovecii, with 8-year follow-up. After a thymectomy, he was diagnosed with Good's syndrome and GL-ILD. He was treated with prophylactic pivampicillin, quinolones and cephalosporins for his recurrent P. jirovecii and H. influenzae infections, an approach that proved unsuccessful due to resistance, with relapse after cessation. He was stabilised with oral diaminodiphenyl-sulfone for P. jirovecii and colistimethate-sodium inhalations for H. influenzae, which is a new approach to prophylactic treatment.
Topics: Adult; Agammaglobulinemia; Anti-Bacterial Agents; Cephalosporins; Granuloma; Haemophilus Infections; Haemophilus influenzae; Humans; Immunologic Deficiency Syndromes; Lung Diseases, Interstitial; Male; Neoplasms, Glandular and Epithelial; Pivampicillin; Pneumocystis Infections; Pneumocystis carinii; Quinolones; Rare Diseases; Thymoma; Thymus Neoplasms
PubMed: 26424818
DOI: 10.1136/bcr-2014-205635 -
BMJ Case Reports Jul 2015We present a case report of a 65-year-old man admitted to the department of infectious diseases on suspicion of meningitis with headache, fever and double vision. A...
We present a case report of a 65-year-old man admitted to the department of infectious diseases on suspicion of meningitis with headache, fever and double vision. A cerebral MRI revealed a 17×30 mm pontine abscess with surrounding oedema. The patient had, 2 months prior to admission, been treated for Streptococcus salivarius aortic valve endocarditis. The abscess was not suitable for surgery, and the patient received multidrug antibiotic treatment for 4 weeks. The patient initially responded well clinically, but was readmitted 4 weeks after discontinuation of treatment, with headache and dizziness. A new cerebral MRI showed progression of the abscess. He received an additional 8 weeks of broad spectrum antibiotic treatment, followed by 12 weeks of oral treatment with pivampicillin. His symptoms resolved and a cerebral MRI at discontinuation of treatment showed regression of the abscess to 7.5 mm.
Topics: Aged; Anti-Bacterial Agents; Aortic Valve; Bicuspid Aortic Valve Disease; Brain Abscess; Drug Therapy, Combination; Endocarditis, Bacterial; Heart Defects, Congenital; Heart Valve Diseases; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Positron-Emission Tomography; Streptococcal Infections; Treatment Outcome
PubMed: 26139646
DOI: 10.1136/bcr-2014-205949 -
Przeglad Epidemiologiczny 2014The Polish results of the international Happy Audit 2 project are reported which objective was to present therapeutic decisions made by general practitioners (especially... (Comparative Study)
Comparative Study
OBJECTIVE
The Polish results of the international Happy Audit 2 project are reported which objective was to present therapeutic decisions made by general practitioners (especially antibiotics prescribed) and diagnostic methods applied to patients with respiratory tract infections (RTI).
MATERIAL AND METHODS
[corrected] Following each visit of patient with respiratory tract infection, general practitioners participating in the study completed the questionnaire. The questionnaire included patient's data (age, gender), the duration of disease, clinical symptoms, diagnosis, prescribed antibiotics, additional testing as well as the influence of various factors on therapeutic decision.
RESULTS
Having considered the results of HappyAudit in Poland, a total of 5,137 office visits of patients reporting symptoms of RTIs were analyzed. The average duration of symptoms before visiting GP was 4.8 days (compared to average 4.4 in other countries). Worth noting is that additional testing in diagnosis of RTIs was performed less frequently in Poland: rapid streptococcal test was conducted in 0.4% of cases (European average: 4.45%), CRP--in 2.2% of patients (average from other countries: 14.2%) and chest X-ray in 2.3% of cases compared to 14% in other project's participants. In Poland, the most frequently applied antibiotic was amoxicillin, which was used in 28.9% of cases ended with antibiotic prescribing (amoxicillin/pivampicillin were also predominant in other countries, excluding Sweden). In Poland, macrolides (22.4% of all prescriptions for antibiotic) and cephalosporins (12.1%) were frequently used. The results indicate that narrow-spectrum antibiotics are prescribed in Poland less frequently, with the example being penicillin V which was prescribed in 6.7% of patients with RTIs who were given antibiotic.
CONCLUSIONS
Comparing the results of Happy Audit 2 in Poland and other project's participants, the major differences consist in rare use of phenoxymethylpenicillin in favour of amoxicillin and macrolides as well as infrequent use of additional testing in diagnosis of RTIs in Poland.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child; Child, Preschool; Clinical Audit; Female; General Practitioners; Humans; Infant; Latvia; Lithuania; Male; Middle Aged; Poland; Practice Patterns, Physicians'; Primary Health Care; Respiratory Tract Infections; Russia; Sweden; Treatment Outcome; Young Adult
PubMed: 25004629
DOI: No ID Found -
The British Journal of Venereal Diseases Dec 1972
Clinical Trial
Topics: Ampicillin; Clinical Trials as Topic; Female; Gonorrhea; Humans; Hydrolysis; Male; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin Resistance; Sex Factors; Valerates; Vomiting
PubMed: 4631231
DOI: 10.1136/sti.48.6.510 -
Genitourinary Medicine Aug 1985Pivampicillin was used to treat urogenital colonisation with Chlamydia trachomatis in 41 women and 24 men who yielded chlamydiae but not gonococci. They were treated for...
Pivampicillin was used to treat urogenital colonisation with Chlamydia trachomatis in 41 women and 24 men who yielded chlamydiae but not gonococci. They were treated for 10 days. All but one patient gave negative chlamydia cultures 10 days after the start of treatment, and all 65 patients gave negative results at the second examination seven days later. Ten days of treatment with pivampicillin seems to be the optimum to eradicate C trachomatis from the lower genital tract in man.
Topics: Ampicillin; Chlamydia Infections; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Pivampicillin
PubMed: 4018807
DOI: 10.1136/sti.61.4.264 -
Canadian Medical Association Journal Nov 1984
Topics: Amoxicillin; Ampicillin; Cyclacillin; Dermatitis; Diarrhea; Humans; Intestinal Absorption; Otitis Media; Pivampicillin; Urinary Tract Infections
PubMed: 6498672
DOI: No ID Found -
Postgraduate Medical Journal Nov 1992A 51 year old female developed a skeletal muscle myopathy after 3 months of pivampicillin therapy. Pivampicillin can cause carnitine deficiency due to the pivalic acid...
A 51 year old female developed a skeletal muscle myopathy after 3 months of pivampicillin therapy. Pivampicillin can cause carnitine deficiency due to the pivalic acid side group. Plasma carnitine content and the patients symptoms failed to improve significantly on discontinuing the drug. Oral carnitine replacement therapy was administered for 6 weeks but the patient's plasma carnitine levels responded only slowly to this treatment. It is suggested that pivampicillin inhibits uptake of carnitine from the gut and may either directly or indirectly depress endogenous carnitine synthesis. In such cases a more aggressive carnitine replacement regime is indicated and pivampicillin should be avoided in patients requiring long-term antibiotic administration.
Topics: Carnitine; Drug Administration Schedule; Female; Humans; Middle Aged; Muscular Diseases; Pivampicillin
PubMed: 1494519
DOI: 10.1136/pgmj.68.805.932 -
British Journal of Clinical Pharmacology Jun 1977
Topics: Amoxicillin; Ampicillin; Cephalexin; Food; Humans; Pivampicillin; Time Factors
PubMed: 901729
DOI: 10.1111/j.1365-2125.1977.tb00752.x -
The British Journal of Venereal Diseases Feb 1975419 patients with uncomplicated gonorrhoea were treated with sulphamethoxazole 4 g. combined with trimethoprim 0-8 g. divided into two doses with an 8-hr interval. The... (Comparative Study)
Comparative Study
419 patients with uncomplicated gonorrhoea were treated with sulphamethoxazole 4 g. combined with trimethoprim 0-8 g. divided into two doses with an 8-hr interval. The failure rate was 1-9 per cent. Parallel with this trial, 319 patients received pivampicillin 1-4 g. combined with probenecid 1 g,; the failure rate was 0-9 per cent. Side-effects were few, four patients in the first group and one in the second group developing a rash. No recurrences were noted in nine patients treated for tonsillar gonorrhoea with the trimethoprim-sulphamethoxazole schedule, while two recurrences were found in thirteen patients treated with pivampicillin-probenecid. The frequency of post-gonococcal urethritis was 7-7 per cent. in the pivampicillin-pro-benecid group against 3-4 per cent. in the trimethoprim-sulphamethoxazole group, a difference which was not statistically significant.
Topics: Ampicillin; Drug Combinations; Dyspepsia; Erythema; Female; Gonorrhea; Humans; Male; Palatine Tonsil; Pivampicillin; Probenecid; Sulfamethoxazole; Trimethoprim
PubMed: 1125747
DOI: 10.1136/sti.51.1.31