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Molecules (Basel, Switzerland) Jan 2020The utilization of polymer/metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied due to their unique properties that... (Review)
Review
The utilization of polymer/metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied due to their unique properties that arise from MOFs or hybrid composite systems. This review focuses on the types of polymer/MOF nanocomposites used in drug delivery and imaging applications. Initially, a comprehensive introduction to the synthesis and structure of MOFs and bio-MOFs is presented. Subsequently, the properties and the performance of polymer/MOF nanocomposites used in these applications are examined, in relation to the approach applied for their synthesis: (i) non-covalent attachment, (ii) covalent attachment, (iii) polymer coordination to metal ions, (iv) MOF encapsulation in polymers, and (v) other strategies. A critical comparison and discussion of the effectiveness of polymer/MOF nanocomposites regarding their synthesis methods and their structural characteristics is presented.
Topics: Biocompatible Materials; Drug Delivery Systems; Hydrogen Bonding; Magnetic Resonance Imaging; Metal-Organic Frameworks; Metals; Nanocomposites; Polymerization; Polymers; Static Electricity
PubMed: 31906398
DOI: 10.3390/molecules25010185 -
International Journal of Molecular... May 2024Due to their biocompatibility and non-toxic nature, biomedical polymer materials have found widespread applications and significantly propelled the progress of the...
Due to their biocompatibility and non-toxic nature, biomedical polymer materials have found widespread applications and significantly propelled the progress of the biomedical field [...].
Topics: Biocompatible Materials; Polymers; Humans
PubMed: 38791127
DOI: 10.3390/ijms25105088 -
International Journal of Molecular... Oct 2022In the present Special Issue "Functional Nanomaterials and Polymer Nanocomposites: Current Uses and Potential Applications", two review articles and nine original...
In the present Special Issue "Functional Nanomaterials and Polymer Nanocomposites: Current Uses and Potential Applications", two review articles and nine original research articles are published [...].
Topics: Polymers; Nanocomposites
PubMed: 36361503
DOI: 10.3390/ijms232112713 -
Molecules (Basel, Switzerland) Jan 2005In this work, polymer-drugs conjugates used as drug delivery systems (DDS) are revised attending to their chemical conjugation. Namely, the classification of this type... (Review)
Review
In this work, polymer-drugs conjugates used as drug delivery systems (DDS) are revised attending to their chemical conjugation. Namely, the classification of this type of DDS is based on the conjugation sites of the reactive groups (i.e., via end groups or pendant polymer groups). Advantages and limitations of these types of DDS are discussed through representative examples of polymer-drugs and polymer-proteins conjugates recently developed.
Topics: Drug Delivery Systems; Models, Biological; Pharmaceutical Preparations; Polymers
PubMed: 18007281
DOI: 10.3390/10010114 -
Bioconjugate Chemistry Mar 2017As potent and selective therapeutic agents, peptides and proteins are an important class of drugs, but they typically have suboptimal pharmacokinetic profiles. One... (Review)
Review
As potent and selective therapeutic agents, peptides and proteins are an important class of drugs, but they typically have suboptimal pharmacokinetic profiles. One approach to solve this problem is their conjugation with "stealth" polymers. Conventional methods for conjugation of this class of polymers to peptides and proteins are typically carried out by reactions that have poor yield and provide limited control over the site of conjugation and the stoichiometry of the conjugate. To address these limitations, new chemical and biological approaches have been developed that provide new molecular tools in the bioconjugation toolbox to create stealth polymer conjugates of peptides and proteins with exquisite control over their properties. This review article highlights these recent advances in the synthesis of therapeutic peptide- and protein-stealth polymer conjugates.
Topics: Animals; Chemistry Techniques, Synthetic; Humans; Models, Molecular; Peptides; Polymers; Proteins
PubMed: 27998056
DOI: 10.1021/acs.bioconjchem.6b00652 -
Stomatologija 2018The aim of this study is to review polyether ether ketone (PEEK), its characteristics and use in prosthodontics. (Review)
Review
OBJECTIVE
The aim of this study is to review polyether ether ketone (PEEK), its characteristics and use in prosthodontics.
MATERIAL AND METHODS
Information search for articles about PEEK and it's use in prosthodontics between January 2010 and April 2017 was conducted in Medline via PubMed, Science direct, Wiley online library as well as the Web search Google Scholar sources. Twelve full text articles were selected and used in this review.
RESULTS
143 articles were found in the database using keywords: PEEK, prosthodontics, dentistry. Data on the suitability of PEEK polymer were organized according to mechanical, chemical, physical properties and PEEK surface preparation.
CONCLUSIONS
PEEK polymer is suitable to use in prosthodontics. However, there are not enough statements about complications, biofilm formation on PEEK surface and its resistance to compression. More research should be done to find out the results.
Topics: Benzophenones; Biocompatible Materials; Databases, Factual; Dental Materials; Dental Prosthesis; Dental Prosthesis Design; Humans; Ketones; Polyethylene Glycols; Polymers; Prosthodontics
PubMed: 30531169
DOI: No ID Found -
Stomatologija 2017The aim of this study is to review polyether ether ketone (PEEK), its characteristics and use in prosthodontics. (Review)
Review
OBJECTIVE
The aim of this study is to review polyether ether ketone (PEEK), its characteristics and use in prosthodontics.
MATERIAL AND METHODS
Information search for articles about PEEK and it's use in prosthodontics between January 2010 and April 2017 was conducted in Medline via PubMed, Science direct, Wiley online library as well as the Web search Google Scholar sources. Twelve full text articles were selected and used in this review.
RESULTS
143 articles were found in the database using keywords: PEEK, prosthodontics, dentistry. Data on the suitability of PEEK polymer were organized according to mechanical, chemical, physical properties and PEEK surface preparation.
CONCLUSIONS
PEEK polymer is suitable to use in prosthodontics. However, there are not enough statements about complications, biofilm formation on PEEK surface and its resistance to compression. More research should be done to find out the results.
Topics: Benzophenones; Biocompatible Materials; Dental Prosthesis Design; Ketones; Polyethylene Glycols; Polymers
PubMed: 29243680
DOI: No ID Found -
Drug Design, Development and Therapy 2020Film-forming sprays offer many advantages compared to conventional topical preparations because they can provide uniform drug distribution and dose, increased... (Review)
Review
Film-forming sprays offer many advantages compared to conventional topical preparations because they can provide uniform drug distribution and dose, increased bioavailability, lower incidence of irritation, continuous drug release, and accelerated wound healing through moisture control. Film-forming sprays consist of polymers and excipients that improve the characteristics of preparations and enhance the stability of active substances. Each type of polymer and excipient will produce films with different features. Therefore, the various types of polymers and excipients and their evaluation standards need to be examined for the development of a more optimal form of film-forming spray. The selected literature included research on polymers as film-forming matrices and the application of these sprays for medical purposes or for potential medical use. This article discusses the types and concentrations of polymers and excipients, sprayer types, evaluations, and critical parameters in determining the sprayability and film characteristics. The review concludes that both natural and synthetic polymers that have in situ film or viscoelastic properties can be used to optimise topical drug delivery.
Topics: Administration, Topical; Animals; Drug Delivery Systems; Humans; Polymers
PubMed: 32884234
DOI: 10.2147/DDDT.S256666 -
Molecules (Basel, Switzerland) Apr 2023Luminescent polymer nanomaterials not only have the characteristics of various types of luminescent functional materials and a wide range of applications, but also have... (Review)
Review
Luminescent polymer nanomaterials not only have the characteristics of various types of luminescent functional materials and a wide range of applications, but also have the characteristics of good biocompatibility and easy functionalization of polymer nanomaterials. They are widely used in biomedical fields such as bioimaging, biosensing, and drug delivery. Designing and constructing new controllable synthesis methods for multifunctional fluorescent polymer nanomaterials with good water solubility and excellent biocompatibility is of great significance. Exploring efficient functionalization methods for luminescent materials is still one of the core issues in the design and development of new fluorescent materials. With this in mind, this review first introduces the structures, properties, and synthetic methods regarding fluorescent polymeric nanomaterials. Then, the functionalization strategies of fluorescent polymer nanomaterials are summarized. In addition, the research progress of multifunctional fluorescent polymer nanomaterials for bioimaging is also discussed. Finally, the synthesis, development, and application fields of fluorescent polymeric nanomaterials, as well as the challenges and opportunities of structure-property correlations, are comprehensively summarized and the corresponding perspectives are well illustrated.
Topics: Polymers; Nanostructures; Coloring Agents; Drug Delivery Systems
PubMed: 37175229
DOI: 10.3390/molecules28093819 -
Chemical Communications (Cambridge,... Jun 2023Since the first introduction of their concept in the 1980s and 90s, polymer brushes have been the focus of intense research efforts to identify novel physico-chemical... (Review)
Review
Since the first introduction of their concept in the 1980s and 90s, polymer brushes have been the focus of intense research efforts to identify novel physico-chemical properties and responsiveness, and optimise the properties of associated interfaces for an ever growing range of applications. To a large extent, this effort has been enabled by progress in surface initiated controlled polymerisation techniques, allowing a huge diversity of monomers and macromolecular architectures to be harnessed and achieved. However, polymer functionalisation through chemical coupling of various moieties and molecular structures has also played an important role in expanding the molecular design toolbox of the field of polymer brush science. This perspective article reviews recent progress in polymer brush functionalisation, discussing a broad range of strategies for the side chain and end chain chemical modification of these polymer coatings. The impact of the brush architecture on associated coupling is also examined. In turn, the role that such functionalisation approaches play in the patterning and structuring of brushes, as well as their conjugation with biomacromolecules for the design of biofunctional interfaces is then reviewed and discussed.
Topics: Surface Properties; Polymers; Polymerization; Molecular Structure
PubMed: 37194961
DOI: 10.1039/d3cc01082a