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Acta Crystallographica. Section C,... Feb 2022In a detailed powder diffraction study of the structural forms of psilocybin, Sherwood [ C, 36–55] cast doubt that any other anhydrous polymorphs could exist.
In a detailed powder diffraction study of the structural forms of psilocybin, Sherwood [ C, 36–55] cast doubt that any other anhydrous polymorphs could exist.
Topics: Crystallography, X-Ray; Hallucinations; Humans; Hydrogen Bonding
PubMed: 35119383
DOI: 10.1107/S2053229622000511 -
Molecules (Basel, Switzerland) Aug 2021The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal...
The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.
Topics: Crystallography, X-Ray; Hydrogen Bonding; Macrolides; Molecular Conformation; Powder Diffraction; Solvents; Temperature
PubMed: 34443452
DOI: 10.3390/molecules26164869 -
Acta Crystallographica. Section C,... Aug 2019
PubMed: 31380782
DOI: 10.1107/S2053229619010520 -
Acta Crystallographica. Section E,... Apr 2019We report a new polymorph of acridine, CHN, denoted form IX, obtained as thin needles by slow evaporation of a toluene solution. The structure was solved and refined...
We report a new polymorph of acridine, CHN, denoted form IX, obtained as thin needles by slow evaporation of a toluene solution. The structure was solved and refined from powder X-ray data. The structures of five unsolvated forms were previously known, but this is only the second with one mol-ecule in the asymmetric unit. The melting point [differential scanning calorimetry (DSC) onset] and heat of fusion are 108.8 (3) °C and 19.2 (4) kJ mol, respectively.
PubMed: 31161062
DOI: 10.1107/S2056989019003645 -
Acta Crystallographica. Section E,... Jun 2016The crystal structure of anhydrous tris-odium citrate, Na3(C6H5O7), has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using...
The crystal structure of anhydrous tris-odium citrate, Na3(C6H5O7), has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory (DFT). There are two independent five-coordinate Na(+) and one six-coordinate Na(+) cations in the asymmetric unit. The [NaO5] and [NaO6] polyhedra share edges and corners to form a three-dimensional framework. There are channels parallel to the a and b axes in which the remainder of the citrate anions reside. The only hydrogen bonds are an intra-molecular one between the hy-droxy group and one of the terminal carboxyl-ate O atoms and an intermolecular one between a methylene group and the hydroxyl O atom.
PubMed: 27308044
DOI: 10.1107/S2056989016007453 -
Journal of Applied Crystallography Aug 2021X-ray diffractometers primarily designed for surface X-ray diffraction are often used to measure the diffraction from powders, textured materials and fiber-texture...
X-ray diffractometers primarily designed for surface X-ray diffraction are often used to measure the diffraction from powders, textured materials and fiber-texture samples in 2θ scans. Unlike in high-energy powder diffraction, only a fraction of the powder rings is typically measured, and the data consist of many detector images across the 2θ range. Such diffractometers typically scan in directions not possible on a conventional laboratory diffractometer, which gives enhanced control of the scattering vector relative to the sample orientation. There are, however, very few examples where the measured intensity is directly used, such as for profile/Rietveld refinement, as is common with other powder diffraction data. Although the underlying physics is known, converting the data is time consuming and the appropriate corrections are dispersed across several publications, often not with powder diffraction in mind. This paper presents the angle calculations and correction factors required to calculate meaningful intensities for 2θ scans with a (2 + 3)-type diffractometer and an area detector. Some of the limitations with respect to texture, refraction and instrumental resolution are also discussed, as is the kind of information that one can hope to obtain.
PubMed: 34429722
DOI: 10.1107/S1600576721006245 -
Molecules (Basel, Switzerland) Nov 2022Tafamidis, chemical formula CHClNO, is a drug used to delay disease progression in adults suffering from transthyretin amyloidosis, and is marketed worldwide under...
Tafamidis, chemical formula CHClNO, is a drug used to delay disease progression in adults suffering from transthyretin amyloidosis, and is marketed worldwide under different tradenames as a free acid or in the form of its meglumine salt. The free acid (CAS no. 594839-88-0) is reported to crystallize as distinct (polymorphic) crystal forms, the thermal stability and structural features of which remained thus far undisclosed. In this paper, we present-by selectively isolating highly pure batches of Tafamidis Form 1 and Tafamidis Form 4-the full characterization of these solids, in terms of crystal structures (determined using state-of-the-art structural powder diffraction methods) and spectroscopic and thermal properties. Beyond conventional thermogravimetric and calorimetric analyses, variable-temperature X-ray diffraction was employed to measure the highly anisotropic response of these (poly)crystalline materials to thermal stimuli and enabled the determination of the linear and volumetric thermal expansion coefficients and of the related indicatrix. Both crystal phases are monoclinic and contain substantially flat and π-π stacked Tafamidis molecules, arranged as centrosymmetric dimers by strong O-H···O bonds; weaker C-H···N contacts give rise, in both polymorphs, to infinite ribbons, which guarantee the substantial stiffness of the crystals in the direction of their elongation. Complete knowledge of the structural models will foster the usage of full-pattern quantitative phase analyses of Tafamidis in drug and polymorphic mixtures, an important aspect in both the forensic and the industrial sectors.
Topics: Crystallization; Powder Diffraction; X-Ray Diffraction
PubMed: 36364244
DOI: 10.3390/molecules27217411 -
IUCrData May 2020The crystal structure of di-ammonium potassium citrate, 2NH ·K·CHO , has been solved and refined using laboratory X-ray powder diffraction data and optimized using...
The crystal structure of di-ammonium potassium citrate, 2NH ·K·CHO , has been solved and refined using laboratory X-ray powder diffraction data and optimized using density functional theory. The KO coordination polyhedra are isolated. The ammonium cations and the hydro-phobic methyl-ene sides of the citrate anions occupy the spaces between the coordination polyhedra. Each hydrogen atom of the ammonium ions acts as a donor in a charge-assisted N-H⋯O, N-H⋯(O,O) or N-H⋯(O,O,O) hydrogen bond. There is an intra-molecular O-H⋯O hydrogen bond in the citrate anion between the hydroxide group and one of the terminal carboxyl-ate groups.
PubMed: 36337153
DOI: 10.1107/S2414314620006124 -
Acta Crystallographica Section B,... Apr 2021Dehydrocoupling of the adduct of dimethylamine and borane, NH(CH)-BH leads to dimethylaminoborane with formal composition N(CH)-BH. The structure of this product depends...
Dehydrocoupling of the adduct of dimethylamine and borane, NH(CH)-BH leads to dimethylaminoborane with formal composition N(CH)-BH. The structure of this product depends on the conditions of the synthesis; it may crystallize either as a dimer in a triclinic space group forming a four-membered ring [N(CH)-BH] or as a trimer forming a six-membered ring [N(CH)-BH] in an orthorhombic space group. Due to the denser packing, the six-membered ring in the trimer structure should be energetically more stable than the four-membered ring. The triclinic structure is stable at low temperatures. Heating the triclinic phase above 290 K leads to a second-order phase transition to a new monoclinic polymorph. While the crystal structures of the triclinic and orthorhombic phases were already known in the literature, the monoclinic crystal structure was determined from powder diffraction data in this study. Monoclinic dimethylaminoborane crystallizes in space group C2/m with the boron and nitrogen atoms located on the mirror plane, Wyckoff position 4i, while the carbon and hydrogen atoms are on the general position 8j.
PubMed: 33843738
DOI: 10.1107/S2052520621001979 -
Journal of Applied Crystallography Jun 2022A description is given of the program . This program is used for visualizing powder diffraction data and models published in powder CIF format (pdCIF). In particular,...
A description is given of the program . This program is used for visualizing powder diffraction data and models published in powder CIF format (pdCIF). In particular, support for the visualization of multi-pattern data sets, such as diffraction experiments, is provided by means of stack and surface plots. is written in Python 3 and can run wherever a compatible runtime is available. macros for the production of pdCIF files are also presented.
PubMed: 35719308
DOI: 10.1107/S1600576722003478