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Experimental Eye Research Sep 2022Our goal was to quantify the age-related changes in the dynamic accommodative movements of the vitreous and aqueous humor in iridic, aniridic, phakic and aphakic primate...
Our goal was to quantify the age-related changes in the dynamic accommodative movements of the vitreous and aqueous humor in iridic, aniridic, phakic and aphakic primate eyes. Six bilaterally iridic and four bilaterally iridectomized rhesus monkeys, ranging in age from 6 to 25 years, received a stimulating electrode in the midbrain Edinger-Westphal nucleus to induce accommodation, measured by a Hartinger coincidence refractometer. One of the four iridectomized monkeys underwent unilateral extracapsular and another monkey underwent intracapsular lens extraction. Eyes were imaged utilizing specialized techniques and contrast agents to resolve intraocular structures. During accommodation the anterior hyaloid membrane and the posterior lens capsule bowed backward. Central vitreous fluid and structures/strands moved posteriorly toward the optic nerve region as peripheral vitreous, attached to the vitreous zonule, was pulled forward by ciliary muscle contraction. Triamcinolone particles injected intravitreally were also observed in the anterior chamber and moved from the anterior chamber toward the cleft of the anterior hyaloid membrane and then further posteriorly into the vitreous-filled cleft between the vitreous zonule and the ciliary body pars plana. These accommodative movements occurred in all eyes, and declined with age. There are statistically significant accommodative movements of various intravitreal structures. The posterior/anterior fluid flow between the anterior chamber and the vitreous compartments during accommodation/disaccommodation represents fluid displacement to allow/facilitate lens thickening. The posterior accommodative movement of central vitreous fluid may result from centripetal compression of the anterior tips of the cistern-like structure attached to the vitreous zonule, and posterior displacement of the central trunk of the cistern during ciliary muscle contraction and centripetal muscle movement. The findings may have implications for presbyopia.
Topics: Accommodation, Ocular; Animals; Ciliary Body; Lens, Crystalline; Macaca mulatta; Presbyopia
PubMed: 35283107
DOI: 10.1016/j.exer.2022.109029 -
Ophthalmology and Therapy Oct 2023Intrastromal lenticule implantation is a promising treatment option for corneal pathologies, from refractive error to ectasia. In this narrative review, we intend to... (Review)
Review
INTRODUCTION
Intrastromal lenticule implantation is a promising treatment option for corneal pathologies, from refractive error to ectasia. In this narrative review, we intend to feature up-to-date literature supporting the use of lenticular tissue, a compelling method that can be customized for a variety of applications, providing an additional source of donor tissue for treating corneal diseases.
METHODS
We searched databases PubMed, Mendeley, and Scopus last accessed 10 May 2023, for literature on stromal lenticules and narrowed based on relevance. Review articles, animal studies, ex vivo studies, and book chapters were excluded, while assessable and relevant articles published in English were included.
RESULTS
Storage methods from using fresh lenticules to dehydration have proven successful, with cryopreservation maintaining structure and cellular viability for up to 10 years. Successful use of lenticules for treatment of numerous pathologies including corneal ectasias, hyperopia, and presbyopia with additional insight into the treatment of corneal ulcers and perforations are highlighted in this narrative review.
CONCLUSION
Lenticular implantation is an innovative and advantageous treatment for various ocular pathologies, offering increased bioavailability, flexibility, and customization for patients. They can treat previously untreatable diseases and serve as a replacement for synthetic implants, with promising outcomes worldwide. Lenticular implantation has the potential to become a leading approach in ophthalmologic surgery. Further studies should aim to provide evidentiary support for a standardization of lenticule banking.
PubMed: 37516716
DOI: 10.1007/s40123-023-00765-2 -
International Journal of Ophthalmology 2021To assess the clinical performance of a multifocal corneoscleral lens for the presbyopia correction.
AIM
To assess the clinical performance of a multifocal corneoscleral lens for the presbyopia correction.
METHODS
A prospective clinical trial of the Onefit™ A multifocal corneoscleral lens was conducted with 40 participants with presbyopia. At 4wk of continuous wear of the corneoscleral lens, changes in the distance, intermediate, and near visual acuity (VA) were evaluated. The safety of the corneoscleral lens, central corneal thickness (CCT), corneal endothelial cell count, binocular stereopsis, tear film break-up time (BUT), corneal staining, corneal edema, corneal neovascularization (NV), and conjunctival hyperemia were examined. In addition, a subjective questionnaire addressing satisfaction (rated from 1 to 5 points) and discomfort (rated from 1 to 5 points) was administered.
RESULTS
Forty participants were enrolled in this study. Six participants were excluded because of poor compliance with lens fitting (=2) and loss to follow-up (=4). The mean age of the participants was 53.0±4.9y. At 4wk of continuous wear of the corneoscleral lens, the best corrected far, intermediate, and near VA was 0.08±0.11, 0.10±0.12, and 0.10±0.12 logMAR, respectively. These results were significant improvements over the baseline uncorrected VA (far: =0.004; intermediate: =0.004; near: =0.002). CCT, corneal endothelial cell count, binocular stereopsis, BUT, corneal staining, corneal edema, corneal NV, and conjunctival hyperemia were not significantly different between baseline and after corneoscleral lens use. The average satisfaction scores for fit sensation; corrected far, intermediate, and near VA; and ease of handling were 4.1, 3.4, 3.6, 3.5, and 3.4, respectively. The average discomfort scores for dryness, irritation, foreign body sensation, redness, fogging, and halo were 1.7, 1.8, 1.5, 1.7, 1.7, and 1.3, respectively.
CONCLUSION
Far, intermediate, and near VA are improved in presbyopic patients with the multifocal corneoscleral lens compared to uncorrected baseline VA, without adverse ocular effects. This evidence supports the safety and effectiveness of presbyopia correction with multifocal corneoscleral lenses.
PubMed: 33875943
DOI: 10.18240/ijo.2021.04.08 -
Contact Lens & Anterior Eye : the... Apr 2024This paper seeks to outline the history, market situation, clinical management and product performance related to the correction of presbyopia with both contact lenses...
This paper seeks to outline the history, market situation, clinical management and product performance related to the correction of presbyopia with both contact lenses and spectacles. The history of the development of various optical forms of presbyopic correction are reviewed, and an overview is presented of the current market status of contact lenses and spectacles. Clinical considerations in the fitting and aftercare of presbyopic contact lens and spectacle lens wearers are presented, with general recommendations for best practice. Current options for contact lens correction of presbyopia include soft simultaneous, rigid translating and rigid simultaneous designs, in addition to monovision. Spectacle options include single vision lenses, bifocal lenses and a range of progressive addition lenses. The comparative performance of both contact lens and spectacle lens options is presented. With a significant proportion of the global population now being presbyopic, this overview is particularly timely and is designed to act as a guide for researchers, industry and eyecare practitioners alike.
PubMed: 38631935
DOI: 10.1016/j.clae.2024.102158 -
American Journal of Ophthalmology Sep 2023To establish consensus among experts in lens and refractive surgery to guide general ophthalmologists on issues related to presbyopia-correcting intraocular lenses...
PURPOSE
To establish consensus among experts in lens and refractive surgery to guide general ophthalmologists on issues related to presbyopia-correcting intraocular lenses (IOLs).
DESIGN
A modified Delphi method to reach a consensus among experts.
METHODS
A steering committee formulated 105 relevant items grouped into four sections (preoperative considerations, IOL selection, intraoperative considerations, and postoperative considerations). The consensus was defined as ≥ 70% of experts agreeing with the evaluation of a statement.
RESULTS
Ten experts participated and completed all rounds of questionnaires (100% response rate). Of 68 items considered in the preoperative considerations, consensus was achieved in 48 (70.6%). There was a lack of consensus over IOL selection, the experts only agreed on the importance of the patient's habits for the optical IOL design selection. Of the 14 considerations related to intraoperative issues, the experts reached a consensus on 10 (71.4%). The postoperative considerations section reached the highest consensus in 10 items of 13 (76.9%).
CONCLUSIONS
Key recommendations for a diffractive multifocal IOL were a potential postoperative visual acuity > 0.5, a keratometry between 40-45 diopters, a pupil >2.8 mm under photopic conditions and <6.0 mm under scotopic conditions, a root mean square of higher order corneal aberrations <0.5 µm for 6-mm pupil size, while monofocal or non-diffractive IOLs should be considered for patients with coexisting eye disorders. A lack of agreement was found in the issues related to the IOL selection.
Topics: Humans; Presbyopia; Delphi Technique; Lens Implantation, Intraocular; Prosthesis Design; Lenses, Intraocular; Color Vision
PubMed: 37236521
DOI: 10.1016/j.ajo.2023.05.002 -
Translational Vision Science &... Mar 2020To investigate the postoperative inflammatory and wound-healing responses after laser scleral microporation for presbyopia.
PURPOSE
To investigate the postoperative inflammatory and wound-healing responses after laser scleral microporation for presbyopia.
METHODS
Thirty porcine eyes were used for the optimization of laser intensities first. Six monkeys (12 eyes) received scleral microporation with an erbium yttrium aluminum garnet (Er:YAG) laser, and half of the eyes received concurrent subconjunctival collagen gel to modulate wound-healing response. The intraocular pressure (IOP) and the laser ablation depth were evaluated. The animals were euthanized at 1, 6, and 9 months postoperatively. The limbal areas and scleras were harvested for histologic analysis and immunofluorescence of markers for inflammation (CD11b and CD45), wound healing (CD90, tenascin-C, fibronectin, and HSP47), wound contraction (α-smooth muscle actin [α-SMA]), vascular response (CD31), nerve injury (GAP43), and limbal stem cells (P63 and telomerase).
RESULTS
In the nonhuman primate study, there was a significant reduction in IOP after the procedure. Overall, the ablation depth was 76.6% to 81.2% at 1 month and slightly decreased to 71.5% to 72.7% at 9 months. Coagulative necrosis around the micropores, as well as expression of CD11b, CD45, tenascin, fibronectin, HSP47, and GAP43, was distinct at 1 month but subsided with time. Collagen gel treatment significantly suppressed the upregulation of CD11b, CD45, fibronectin, and tenascin-C. The expression of CD90, α-SMA, and CD31 was minimal in all eyes.
CONCLUSIONS
The study demonstrated the course of inflammatory and wound-healing responses following laser scleral microporation. The tissue responses were small and self-limited, resolved with time, and were suppressed by concurrent collagen treatment. It provides a useful understanding of this new procedure.
TRANSLATIONAL RELEVANCE
The results would be helpful in the laser parameter modification to improve the long-term treatment stability.
Topics: Animals; Laser Therapy; Lasers, Solid-State; Presbyopia; Sclera; Swine; Wound Healing
PubMed: 32818094
DOI: 10.1167/tvst.9.4.6 -
Journal of the West African College of... 2022The aim of the study was to assess the pattern of ametropia, presbyopia, and the barriers to the uptake of spectacles among adult patients attending Hajiya Gambo Sawaba...
AIM
The aim of the study was to assess the pattern of ametropia, presbyopia, and the barriers to the uptake of spectacles among adult patients attending Hajiya Gambo Sawaba General Hospital (HGSGH), Zaria, Nigeria.
MATERIALS AND METHODS
This study was a descriptive hospital-based study. The study population was selected by systematic sampling over a 3-month period (July-September, 2016). A questionnaire was administered for sociodemographic data, patients' history, and refraction. Patients with visual acuity less than 6/12 or who required at least +1.00DS to read N8 were given spectacle prescriptions and assessed after 2 months to confirm if they purchased the spectacles.
RESULTS
Two hundred and nine patients were assessed: 124 (59.3%) females and 85 (40.7%) males. The age ranged from 18 to 75 years with a mean of 45.5. One hundred and seventy-five (83.7%) had ametropia, 100 (47.8%) had presbyopia, and patients having both were 66 (31.6%). Astigmatism was the most common ametropia, 118 (67.4%), followed by hypermetropic astigmatism 33 (18.9%) and myopia 24 (13.7%). Only 97 (46.6%) patients purchased their spectacles, and 92 of them were using their spectacles. One hundred and twelve (52.2%) patients did not buy their spectacles, with cost being most common barrier to the uptake of spectacles.
CONCLUSION
There is a high burden of ametropia and presbyopia among patients attending HGSGH, Zaria. Cost of spectacles and 'no felt need' were found to affect spectacle uptake. Health information and availability of low-cost spectacles are important strategies in reducing the burden of uncorrected ametropia and presbyopia in Kaduna State.
PubMed: 36203913
DOI: 10.4103/jwas.jwas_70_22 -
Clinical Ophthalmology (Auckland, N.Z.) 2020To describe a stepwise surgical curriculum that was implemented to teach novice surgeons about currently available advanced technology intraocular lenses (ATIOLs) for...
OBJECTIVE
To describe a stepwise surgical curriculum that was implemented to teach novice surgeons about currently available advanced technology intraocular lenses (ATIOLs) for correction of presbyopia and to report the experiences and surgical results of ATIOL surgery performed by residents who engaged in the curriculum.
DESIGN SETTING AND PARTICIPANTS
Third-year ophthalmology residents participated in a curriculum incorporating didactic lectures (with objective assessment and wet-lab practice) and observation of attending-performed ATIOL surgeries prior to performing ATIOL surgery as primary surgeon under direct supervision. Post-operative outcomes studied were best corrected distance visual acuity (BCDVA) and uncorrected distance (UDVA), intermediate (UIVA) near (UNVA) visual acuity and correction of astigmatism with at least 3 months of follow-up (POM3+). Residents were also given a survey to assess experiences with the surgical curriculum, preparedness for use of ATIOLs post-residency, and ATIOL practice pattern post-residency.
RESULTS
A total of 12 residents from four consecutive classes completed the curriculum. Residents overall had a favorable opinion of the curriculum and felt well prepared to use ATIOLs after training. Graduates who currently perform cataract surgery felt comfortable using all available ATIOLs. A total of 100 eyes from 72 patients met the inclusion criteria for analysis in the study. At the POM3+ timepoint, 88% of eyes had UDVA of 20/30 or better, 93% had UIVA of 20/30 or better, and 71.2% had UNVA of 20/30 (J2) or better. Among eyes that received an astigmatism-correcting ATIOL, 91% had <1 diopter of astigmatism after surgery.
CONCLUSION
Resident surgeons learned to perform ATIOL surgery (medical knowledge) and achieve strong surgical outcomes (patient care) with all currently available ATIOLs after completion of a stepwise curriculum. Educators may be encouraged to incorporate an ATIOL curriculum based on the results of this study. The curriculum presented is a prototype and may be further improved with future experiences and studies.
PubMed: 32921977
DOI: 10.2147/OPTH.S263249 -
Romanian Journal of Ophthalmology 2020to test the refractive and visual outcomes and the quality of vision after the bilateral implantation of three different multifocal intraocular lenses (MIOLs) in... (Comparative Study)
Comparative Study
to test the refractive and visual outcomes and the quality of vision after the bilateral implantation of three different multifocal intraocular lenses (MIOLs) in patients with age-related cataract. In this retrospective, comparative study including 90 eyes of 45 cataract patients, bilateral implantation of either the hydrophilic trifocal Liberty® 677MY capsular bag IOL, the hydrophilic AT LISA® tri 839M lens, or the hydrophobic AcrySof® IQ PanOptix® IOL was performed during routine cataract surgery. Refractive outcomes, visual acuities (VA) for far, intermediate and near distances, as well as visual quality, dysphotopic events and spectacle use were evaluated six months postoperatively. VA curves were similar for the three MIOLs, however the Liberty lens seemed to be superior for far and near, while AT LISA tri provided somewhat better VA in the intermediate range. Refractive correction was the most effective with the Liberty IOL (p=0.0131). Dysphotopic phenomena were usually perceived in low light conditions. Their frequency was lower with the AT LISA tri and Liberty lenses. Symptoms were significantly less disturbing for patients implanted with the Liberty lens, two-thirds of AT LISA tri and Liberty patients, while only 57% of PanOptix patients achieved spectacle independence. All examined MIOLs were found to be safe and efficient in presbyopia-correction of cataract patients, however different models had different advantages. The vision preferences of each patient should always be taken into consideration when choosing a MIOL, and the possible occurrence of dysphotopic events should be also clearly communicated in each case. ACD = Anterior chamber depth, ANOVA = Analysis of variance, AXL = Axial length, CDVA = Corrected distance visual acuity, CYL = Cylinder; Cylindric refraction, D = Diopter, IOL = Intraocular lens, K1; K2 = Keratometry values, MIOL = Multifocal intraocular lens, n = Number of cases, n.a. = Not applicable, Postop = Postoperative, QoV = Quality of Vision, SD = Standard deviation, SEQ = Spherical equivalent, SPH = Sphere; Spherical refraction, UDVA = Uncorrected distance visual acuity, UIVA = Uncorrected intermediate visual acuity, UNVA = Uncorrected near visual acuity, VA = Visual acuity.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Multifocal Intraocular Lenses; Patient Satisfaction; Presbyopia; Prosthesis Design; Refraction, Ocular; Retrospective Studies; Visual Acuity
PubMed: 33367174
DOI: 10.22336/rjo.2020.58 -
Journal of Clinical and Diagnostic... Sep 2017Presbyopia is an age related loss of lens accommodation resulting in inability to read and/write or to do near work. Though literacy level may be low in rural female...
INTRODUCTION
Presbyopia is an age related loss of lens accommodation resulting in inability to read and/write or to do near work. Though literacy level may be low in rural female population of South India, but household works like sewing, sorting grains and operating mobile phones must be difficult due to presbyopia.
AIM
To determine the awareness of presbyopia in rural females; also, to determine the knowledge levels regarding presbyopia, spectacle coverage and reasons for not wearing spectacles.
MATERIALS AND METHODS
A hospital based cross-sectional study was conducted at SDM College of Medical Sciences, Dharwad, Karnataka, India, on 1000 female subjects of age group 35 years and above coming from rural area (around Dharwad). They were examined and open-ended questionnaire was used to record subject's awareness and knowledge about presbyopia and their responses were analysed.
RESULTS
More than 2/3 of 1000 (66.7%) subjects were not aware about presbyopia. More than 50% subjects had difficulty in cleaning grains, threading needles and reading fine newspaper print. About 86.5% thought presbyopia is age related and 92.2% thought it could be treated with spectacles. In spite of high prevalence, almost 98% of the population were not willing to wear glasses among which majority (60.2%) felt that spectacles were difficult to be maintained while working. In the present study, no statistical significance between literacy and awareness was noted (p=0.46).
CONCLUSION
High prevalence of presbyopia was seen with majority of them uncorrected due to lack of awareness or unwillingness to wear glasses. We need to provide better health education regarding presbyopia among both literate and illiterate individuals. Thus, there is a need to create awareness and to provide affordable, accessible and compatible optical services to the affected population.
PubMed: 29207744
DOI: 10.7860/JCDR/2017/26125.10608