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Sexually Transmitted Diseases Jun 2019
Topics: Humans; Proctitis; Sexual Behavior; Sexual Partners; Syphilis
PubMed: 30747798
DOI: 10.1097/OLQ.0000000000000987 -
Vaccines Aug 2022(1) Background: We describe a case of a 58-year-old Chinese woman, without obvious cause of immunosuppression, who developed cytomegalovirus (CMV) proctitis three days...
(1) Background: We describe a case of a 58-year-old Chinese woman, without obvious cause of immunosuppression, who developed cytomegalovirus (CMV) proctitis three days after a second COVID-19 vaccination. Electronic colonoscopy revealed a new lesion that was circumferential at the anorectal junction, with an uneven surface and ulceration, which mimicked rectal carcinoma. This is the first case of CMV proctitis following vaccination since the invention of the COVID-19 vaccine, suggesting that the COVID-19 vaccine may cause disorders of immune homeostasis, including not only immune hyperactivity but also immune deficiency. We report this case to increase readers' awareness of the risks after COVID-19 vaccination and to provide new ideas for the diagnosis and treatment of similar cases. (2) Methods: In this case, we used laboratory biochemical examinations, colonoscopy, immunohistochemistry, and a biochemical index to confirm the existence of CMV proctitis. (3) Results: In this case, the vaccine-induced CMV proctitis had a similar endoscopic appearance to rectal neoplastic lesions, which could be confirmed by biopsy and quickly relieved by ganciclovir treatment. Ganciclovir was used to treat the patient, and a good effect was observed. (4) Conclusions: COVID-19 vaccination may cause immune disorders, not just immune hyperactivity as previously reported, but also immune deficiency, such as CMV proctitis in this case. The clinical course of CMV proctitis secondary to COVID-19 vaccination was favorable with ganciclovir therapy.
PubMed: 36146495
DOI: 10.3390/vaccines10091417 -
British Medical Journal (Clinical... Jan 1982
Topics: Colitis, Ulcerative; Cromolyn Sodium; Drug Hypersensitivity; Humans; Proctitis; Sulfasalazine
PubMed: 6119135
DOI: 10.1136/bmj.284.6309.70 -
Gut Sep 1962This paper presents the natural history of idiopathic proctitis and concludes that this disease and idiopathic procto-colitis are two manifestations of one disease...
This paper presents the natural history of idiopathic proctitis and concludes that this disease and idiopathic procto-colitis are two manifestations of one disease differing only in the extent of the colon involved.
Topics: Chronic Disease; Colitis; Colitis, Ulcerative; Humans; Proctitis
PubMed: 13929631
DOI: 10.1136/gut.3.3.201 -
In Vivo (Athens, Greece) 2021This comprehensive synopsis summarizes the most relevant information obtained from a systematic analysis of studies of the last decade on radiation proctitis, one of the... (Review)
Review
This comprehensive synopsis summarizes the most relevant information obtained from a systematic analysis of studies of the last decade on radiation proctitis, one of the most feared radioinduced side effects among prostate cancer patients treated with curative external beam radiotherapy. The present review provides a useful support to radiation oncologists for limiting the onset or improving the treatment of radiation proctitis. This work shows that the past decade was a harbinger of significant new evidence in technological advances and technical tricks to avoid radiation proctitis, in addition to dosimetric perspectives and goals, understanding of pathogenesis, diagnostic work-up and treatment. We believe that a well-rounded knowledge of such an issue is fundamental for its appropriate management.
Topics: Humans; Male; Proctitis; Prostatic Neoplasms; Radiation Injuries; Radiotherapy Dosage
PubMed: 33910815
DOI: 10.21873/invivo.12390 -
Frontiers in Cellular and Infection... 2022This study aimed to investigate the protective effect of ginsenoside Rg3 (GRg3) against acute radiation proctitis (ARP) in rats.
OBJECTIVES
This study aimed to investigate the protective effect of ginsenoside Rg3 (GRg3) against acute radiation proctitis (ARP) in rats.
METHODS
Wistar rats were randomly divided into control, model, dexamethasone-positive, GRg3 low-dose, GRg3 medium-dose, and GRg3 high-dose groups. The ARP rat model was established by a single 22-Gy irradiation of 6 MV) X-rays. The distribution and function of intestinal flora were detected using 16S rRNA high-throughput sequencing, rectal tissue was observed by hematoxylin and eosin (H&E) staining, the expression of interleukin 1β (IL-1β) and IL-10 inflammatory factors was detected by ELISA, and mRNA and protein expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were detected by RT-qPCR and Western blotting, respectively.
RESULTS
GRg3 improved the symptoms of ARP in rats in a dose-dependent manner. The species distribution of intestinal flora in GRg3 rats was significantly different from that in ARP rats. These differences were more significant in the high-dose group, where the numbers of , , and other beneficial bacteria were significantly increased, whereas those of , , and other harmful bacteria were decreased. In addition, GRg3 was closely related to amino acid metabolism. After GRg3 treatment, the mRNA and protein expression of TLR4, MyD88, and NF-κB in rectal tissue was significantly down-regulated, and the level of downstream inflammatory factor IL-1β decreased, whereas that of IL-10 increased.
CONCLUSION
Our study indicated GRg3 as a new compound for the treatment of ARP by inhibiting the TLR4/MyD88/NF-κB pathway, down-regulating the expression of proinflammatory factors, thus effectively regulating intestinal flora and reducing inflammatory reactions.
Topics: Animals; Rats; Gastrointestinal Microbiome; Interleukin-10; Myeloid Differentiation Factor 88; NF-kappa B; Proctitis; Rats, Wistar; RNA, Ribosomal, 16S; Signal Transduction; Toll-Like Receptor 4; Radiation Injuries
PubMed: 36683687
DOI: 10.3389/fcimb.2022.1028576 -
California Medicine Sep 1961There being no new or advanced technical aids to help the clinician in evaluating colon dysfunction, he must still depend on a careful history, knowledge of the patient,...
There being no new or advanced technical aids to help the clinician in evaluating colon dysfunction, he must still depend on a careful history, knowledge of the patient, physical examination, which includes sigmoidoscopy, and a few appropriate diagnostic laboratory procedures to arrive at the proper diagnosis. With these means, it is possible to make a positive diagnosis of irritable bowel syndrome, and differentiate it from diverticulitis, ulcerative proctitis and polypoid disease.
Topics: Colitis, Ulcerative; Colon; Disease; Humans; Irritable Bowel Syndrome; Male; Proctitis; Sigmoidoscopy
PubMed: 13703114
DOI: No ID Found -
American Family Physician Jul 2001Patients with a wide variety of anorectal lesions present to family physicians. Most can be successfully managed in the office setting. A high index of suspicion for... (Review)
Review
Patients with a wide variety of anorectal lesions present to family physicians. Most can be successfully managed in the office setting. A high index of suspicion for cancer should be maintained and all patients should be questioned about relevant family history or other indications for cancer screening. Patients with condylomata acuminata must be examined for human papillomavirus infection elsewhere after treatment of the presenting lesions. Their sexual partners should also be counseled and screened. Both surgical and nonsurgical treatments are available for the pain of anal fissure. Infection in the anorectal area may present as different types of abscesses, cryptitis, fistulae or perineal sepsis. Fistulae may result from localized infection or indicate inflammatory bowel disease. Protrusion of tissue through the anus may be due to hemorrhoids, mucosal prolapse, polyps or other lesions.
Topics: Abscess; Anal Canal; Anus Diseases; Anus Neoplasms; Condylomata Acuminata; Constriction, Pathologic; Fissure in Ano; Hemorrhoids; Humans; Proctitis; Rectal Diseases; Rectal Fistula; Rectal Neoplasms; Rectal Prolapse; Rectum
PubMed: 11456437
DOI: No ID Found -
Brachytherapy 2020The purpose of the study was to report the outcomes of a single-center adjuvant electronic brachytherapy (e-BT) experience for patients with endometrial carcinoma.
PURPOSE
The purpose of the study was to report the outcomes of a single-center adjuvant electronic brachytherapy (e-BT) experience for patients with endometrial carcinoma.
METHODS AND MATERIALS
Patients were retrospectively assessed. Intracavitary e-BT was applied through a cylindrical applicator (diameters 2.5-3.5 cm). e-BT single doses ranged between 4 and 7 Gy (EQD2 ∼ 6-12, α/β of 10 Gy and an relative biological effectiveness of 1.3) at 5-mm depth. Adverse events are reported at first week, 1-3 months, 3-12 months, 12-24 months, and >24 months. The overall survival, disease-free survival, distant disease control rate, and local control rate were estimated using the Kaplan-Meier method.
RESULTS
Twenty-nine patients were assessed. The median age was 68 [48-86] years. External beam radiotherapy was added in n = 8 (27.6%) patients. Staging was 13.8% for T1a, 51.7% for T1b, 24.1% for T2, 6.9% for T3a, and 3.4% for T3b. Grading was G3 in 51.7% (n = 15), G2 in 20.7% (n = 6), and G1 in 27.6% (n = 8). Median followup was 47 months [5-88]. Overall Grade 1, 2, and 3 toxicity was 89.7% (n = 26), 17.2% (n = 5), and 6.9% (n = 2), respectively. No Grade 3 cystitis or proctitis or any Grade 4 or 5 toxicity occurred during followup. No local recurrences were detected. Estimated distant disease control rate was 92.1% (n = 2, distant metastasis at 7 and 11 months). Estimated 4-year overall survival was 84.8% (n = 4 events, two unrelated to disease) and disease-free survival was 84.6%.
CONCLUSIONS
Our data suggest that e-BT resembles a very-low-toxicity profile and a high local control rate in the adjuvant scenario for patients with endometrial carcinoma.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Brachytherapy; Cystitis; Disease-Free Survival; Electronics; Endometrial Neoplasms; Female; Humans; Kaplan-Meier Estimate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Pelvic Pain; Proctitis; Radiation Injuries; Radiotherapy; Retrospective Studies; Survival Rate; Vaginal Diseases
PubMed: 32651094
DOI: 10.1016/j.brachy.2020.06.002 -
Clinical Imaging Dec 2022The monkeypox outbreak of 2022 saw the first community-sustained transmission of the monkeypox virus outside of Africa, and rapidly developed into multi-country spread....
The monkeypox outbreak of 2022 saw the first community-sustained transmission of the monkeypox virus outside of Africa, and rapidly developed into multi-country spread. A common presenting sign of monkeypox infection during this outbreak has been rectal pain due to proctitis. Proctitis with large hypoattenuated anorectal ulcers on CT scan should invoke consideration for monkeypox infection in young homosexual or bisexual men with associated skin eruptions.
Topics: Male; Humans; Mpox (monkeypox); Proctitis; Rectum; Disease Outbreaks
PubMed: 36302321
DOI: 10.1016/j.clinimag.2022.10.008