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Environmental Health Perspectives Dec 1977Haloorganic biocides are widely employed as soil fumigants to combat the destructive action of plant parasitic nematodes and fungi. These substances are dehalogenated by...
Haloorganic biocides are widely employed as soil fumigants to combat the destructive action of plant parasitic nematodes and fungi. These substances are dehalogenated by soil organisms, principally species of Pseudomonas and Flavobacteria, to nontoxic metabolities. The paths of metabolism of a vareity of simply alkyl halides are described with emphasis upon the biodehalogenation step.
Topics: 1-Propanol; Allyl Compounds; Animals; Biotransformation; Butanes; Ethylene Dibromide; Hemeproteins; Hydrocarbons, Chlorinated; Hydrocarbons, Halogenated; Hydrolysis; Nematoda; Oxidation-Reduction; Propane; Propanols; Pseudomonas; Soil Microbiology
PubMed: 348458
DOI: 10.1289/ehp.7721279 -
Nature Microbiology Jan 2024Gut environments harbour dense microbial ecosystems in which plasmids are widely distributed. Plasmids facilitate the exchange of genetic material among microorganisms...
Gut environments harbour dense microbial ecosystems in which plasmids are widely distributed. Plasmids facilitate the exchange of genetic material among microorganisms while enabling the transfer of a diverse array of accessory functions. However, their precise impact on microbial community composition and function remains largely unexplored. Here we identify a prevalent bacterial toxin and a plasmid-encoded resistance mechanism that mediates the interaction between Lactobacilli and Enterococci. This plasmid is widespread across ecosystems, including the rumen and human gut microbiota. Biochemical characterization of the plasmid revealed a defence mechanism against reuterin, a toxin produced by various gut microbes, such as Limosilactobacillus reuteri. Using a targeted metabolomic approach, we find reuterin to be prevalent across rumen ecosystems with impacts on microbial community structure. Enterococcus strains carrying the protective plasmid were isolated and their interactions with L. reuteri, the toxin producer, were studied in vitro. Interestingly, we found that by conferring resistance against reuterin, the plasmid mediates metabolic exchange between the defending and the attacking microbial species, resulting in a beneficial relationship or mutualism. Hence, we reveal here an ecological role for a plasmid-coded defence system in mediating a beneficial interaction.
Topics: Humans; Animals; Symbiosis; Ecosystem; Plasmids; Propane; Limosilactobacillus reuteri; Enterococcus
PubMed: 38151647
DOI: 10.1038/s41564-023-01521-9 -
Report on Carcinogens : Carcinogen... 2011
Topics: Animals; Carcinogens; Detergents; Environmental Exposure; Humans; Neoplasms; Propane
PubMed: 21869844
DOI: No ID Found -
Report on Carcinogens : Carcinogen... 2011
Topics: Animals; Carcinogens; Government Regulation; Humans; Hydrocarbons, Halogenated; Occupational Exposure; Propane; United States
PubMed: 21852817
DOI: No ID Found -
Medical Gas Research 2019
Topics: Butanes; Cryosurgery; Gases; Gingival Diseases; Heterocyclic Compounds; Humans; Nitrogen; Odontogenic Tumors; Pigmentation Disorders; Propane
PubMed: 30950420
DOI: 10.4103/2045-9912.254642 -
IARC Monographs on the Evaluation of... 1995
Review
Topics: Animals; Carcinogenicity Tests; Carcinogens; Humans; Propane
PubMed: 9097094
DOI: No ID Found -
IARC Monographs on the Evaluation of... 1999
Review
Topics: Animals; Bacteria; Carcinogenicity Tests; Carcinogens; Humans; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Propane; Solvents
PubMed: 10476418
DOI: No ID Found -
Environmental Science and Pollution... Sep 20121,2,3-Trichloropropane (TCP) is a persistent groundwater pollutant and a suspected human carcinogen. It is also is an industrial chemical waste that has been formed in... (Review)
Review
PURPOSE
1,2,3-Trichloropropane (TCP) is a persistent groundwater pollutant and a suspected human carcinogen. It is also is an industrial chemical waste that has been formed in large amounts during epichlorohydrin manufacture. In view of the spread of TCP via groundwater and its toxicity, there is a need for cheap and efficient technologies for the cleanup of TCP-contaminated sites. In situ or on-site bioremediation of TCP is an option if biodegradation can be achieved and stimulated. This paper presents an overview of methods for the remediation of TCP-contaminated water with an emphasis on the possibilities of biodegradation.
CONCLUSIONS
Although TCP is a xenobiotic chlorinated compound of high chemical stability, a number of abiotic and biotic conversions have been demonstrated, including abiotic oxidative conversion in the presence of a strong oxidant and reductive conversion by zero-valent zinc. Biotransformations that have been observed include reductive dechlorination, monooxygenase-mediated cometabolism, and enzymatic hydrolysis. No natural organisms are known that can use TCP as a carbon source for growth under aerobic conditions, but anaerobically TCP may serve as electron acceptor. The application of biodegradation is hindered by low degradation rates and incomplete mineralization. Protein engineering and genetic modification can be used to obtain microorganisms with enhanced TCP degradation potential.
Topics: Animals; Bacteria; Biodegradation, Environmental; Carcinogens; Humans; Metabolic Engineering; Propane; Protein Engineering; Water Pollutants; Zinc
PubMed: 22875418
DOI: 10.1007/s11356-012-0859-3 -
International Journal of Molecular... Mar 2024Poly(propylene carbonate) (PPC) is an emerging "carbon fixation" polymer that holds the potential to become a "biomaterial of choice" in healthcare owing to its good... (Review)
Review
Poly(propylene carbonate) (PPC) is an emerging "carbon fixation" polymer that holds the potential to become a "biomaterial of choice" in healthcare owing to its good biocompatibility, tunable biodegradability and safe degradation products. However, the commercialization and wide application of PPC as a biomedical material are still hindered by its narrow processing temperature range, poor mechanical properties and hydrophobic nature. Over recent decades, several physical, chemical and biological modifications of PPC have been achieved by introducing biocompatible polymers, inorganic ions or small molecules, which can endow PPC with better cytocompatibility and desirable biodegradability, and thus enable various applications. Indeed, a variety of PPC-based degradable materials have been used in medical applications including medical masks, surgical gowns, drug carriers, wound dressings, implants and scaffolds. In this review, the molecular structure, catalysts for synthesis, properties and modifications of PPC are discussed. Recent biomedical applications of PPC-based biomaterials are highlighted and summarized.
Topics: Biocompatible Materials; Polymers; Prostheses and Implants; Propane
PubMed: 38474185
DOI: 10.3390/ijms25052938 -
Nature Communications Oct 2022Anaerobic microorganisms are thought to play a critical role in regulating the flux of short-chain gaseous alkanes (SCGAs; including ethane, propane and butane) from...
Anaerobic microorganisms are thought to play a critical role in regulating the flux of short-chain gaseous alkanes (SCGAs; including ethane, propane and butane) from terrestrial and aquatic ecosystems to the atmosphere. Sulfate has been confirmed to act as electron acceptor supporting microbial anaerobic oxidation of SCGAs, yet several other energetically more favourable acceptors co-exist with these gases in anaerobic environments. Here, we show that a bioreactor seeded with biomass from a wastewater treatment facility can perform anaerobic propane oxidation coupled to nitrate reduction to dinitrogen gas and ammonium. The bioreactor was operated for more than 1000 days, and we used C- and N-labelling experiments, metagenomic, metatranscriptomic, metaproteomic and metabolite analyses to characterize the microbial community and the metabolic processes. The data collectively suggest that a species representing a novel order within the bacterial class Symbiobacteriia is responsible for the observed nitrate-dependent propane oxidation. The closed genome of this organism, which we designate as 'Candidatus Alkanivorans nitratireducens', encodes pathways for oxidation of propane to CO via fumarate addition, and for nitrate reduction, with all the key genes expressed during nitrate-dependent propane oxidation. Our results suggest that nitrate is a relevant electron sink for SCGA oxidation in anaerobic environments, constituting a new microbially-mediated link between the carbon and nitrogen cycles.
Topics: Alkanes; Ammonium Compounds; Anaerobiosis; Butanes; Carbon; Carbon Dioxide; Ecosystem; Ethane; Fumarates; Methane; Nitrates; Oxidation-Reduction; Propane; Sulfates
PubMed: 36253480
DOI: 10.1038/s41467-022-33872-y