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BMJ Case Reports Oct 2018
Topics: Analgesics; Biopsy; Diagnosis, Differential; Female; Gabapentin; Humans; Middle Aged; Pseudolymphoma; Skin Diseases
PubMed: 30344158
DOI: 10.1136/bcr-2018-227245 -
Journal of Cutaneous Pathology Oct 2017Acral angiokeratoma-like pseudolymphoma is a rare type of pseudolymphoma presenting as dark-red papules on the hand or foot. We describe a 59-year-old woman who...
Acral angiokeratoma-like pseudolymphoma is a rare type of pseudolymphoma presenting as dark-red papules on the hand or foot. We describe a 59-year-old woman who presented with an unusual unilateral, clustered aggregate of scaly violaceous papules on the toe with an indolent course. Skin biopsy showed a prominent vascular proliferation associated with a dermal infiltrate of monoclonally rearranged T-follicular helper phenotype T-cells, in keeping with CD4+ small/medium T-cell lymphoproliferative disorder (SMPTC-LPD). Based on the unique clinical morphology, distribution of the lesions and dermoscopic appearance, a clinicopathologic diagnosis of acral angiokeratoma-like pseudolymphoma was favored. This case demonstrates the importance of clinicopathological correlation in such diagnostically challenging patients who present with overlapping features on the spectrum of pseudolymphoma and cutaneous T-cell lymphoma.
Topics: Angiokeratoma; Female; Humans; Lymphoma, T-Cell, Cutaneous; Middle Aged; Skin Neoplasms; T-Lymphocytes, Helper-Inducer; Toes
PubMed: 28675468
DOI: 10.1111/cup.12999 -
Archives of Pathology & Laboratory... Oct 2011The gastrointestinal tract is the most common site of extranodal lymphomas. Although all histologic categories of malignant lymphoma develop in the gastrointestinal... (Review)
Review
CONTEXT
The gastrointestinal tract is the most common site of extranodal lymphomas. Although all histologic categories of malignant lymphoma develop in the gastrointestinal tract, large B-cell lymphomas predominate, followed by extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) type; the latter is especially prevalent in stomach. The acceptance of extranodal marginal zone lymphoma of MALT type as a clinicopathologic entity has reduced the number of cases that formerly were interpreted as florid lymphoid hyperplasia ("pseudolymphoma"). Nonetheless, the distinction of lymphoid hyperplasia from a lymphoma of MALT type in small biopsy specimens remains problematic.
OBJECTIVE
To assess the relevant morphologic, immunologic, molecular, and genetic properties of gastrointestinal lymphomas and to present a feasible tactic for diagnosis, expressly for small biopsy specimens.
DATA SOURCES
Case-derived material and literature review using PubMed (National Library of Medicine).
CONCLUSIONS
Most gastrointestinal lymphomas are readily amenable to an unqualified diagnosis, primarily those cases consisting of monomorphic large cells whether of B- or T-cell lineage, including cases associated with enteropathy. Diagnosis for infiltrates dominated by small lymphocytes remains taxing, as the differential diagnosis embraces not only MALT lymphoma and lymphoid hyperplasia but also mantle cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma. Adherence to strict morphologic criteria is the standard for diagnosis, but these criteria should be augmented by immunologic studies together with judicious use of molecular techniques to determine clonality. In establishing a diagnosis of gastric marginal zone lymphoma of MALT type, determination of t(11;18)(q21;q21) status may be required since this translocation has clinical ramifications.
Topics: Diagnosis, Differential; Enteropathy-Associated T-Cell Lymphoma; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Humans; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoproliferative Disorders; Pseudolymphoma; Translocation, Genetic
PubMed: 21970484
DOI: 10.5858/arpa.2011-0145-RA -
Italian Journal of Dermatology and... Dec 2021
Review
Topics: Humans; Prurigo; Pseudolymphoma; Scabies
PubMed: 31042856
DOI: 10.23736/S2784-8671.19.06322-3 -
Dermatology Research and Practice 2024Granulomatous dermatoses, particularly on facial skin, pose a diagnostic challenge, as similar histologic patterns can be produced by different causes.
BACKGROUND
Granulomatous dermatoses, particularly on facial skin, pose a diagnostic challenge, as similar histologic patterns can be produced by different causes.
AIM
To evaluate the correlation between clinical suspicion and histopathological findings in various facial granulomatous dermatoses.
MATERIALS AND METHODS
This retrospective, cross-sectional study included all patients with the histopathological diagnosis of facial granulomatous dermatoses from the years 2016 to 2021 in an academic hospital. Demographic, clinical, and histopathologic features were reviewed and analyzed.
RESULTS
In this study, 150 histopathological records with the diagnosis of facial granulomatous dermatoses from the years 2016 to 2021 were reviewed. The most common clinical diagnosis was rosacea 34 (23.6%), followed by sarcoidosis 27 (18.8%), leishmaniasis 15 (10.4%), and granulomatous rosacea 10 (6.9%). The frequency of clinical diagnosis of rosacea (70.6), sarcoidosis (66.7), foreign body G (62.5), TB (75), pseudolymphoma (75), acne agminata (66.7), and granulomatous rosacea (70) in female patients was higher than that in males ( value = 0.03). The effect of age on the type of both clinical and histopathological diagnosis was statistically significant ( value = 0.0001 and 0.004, respectively).
CONCLUSION
Our study contributed significantly to the understanding of the clinicopathological aspects of facial granulomatous dermatoses and advocated for a multidisciplinary approach to the diagnosis and management of these complex skin conditions.
PubMed: 38855081
DOI: 10.1155/2024/9946828 -
Gastrointestinal Radiology 1983A case of pseudolymphoma of the colon is reported. Radiographically and endoscopically the lesion could not be conclusively distinguished from malignant neoplasm,...
A case of pseudolymphoma of the colon is reported. Radiographically and endoscopically the lesion could not be conclusively distinguished from malignant neoplasm, particularly lymphoma or segmental colitis, thus necessitating right hemicolectomy. Careful histological examination established the diagnosis of pseudolymphoma with pathologic features identical to the focal form of pseudolymphoma more commonly observed in the stomach.
Topics: Colonic Diseases; Colonic Neoplasms; Diagnosis, Differential; Humans; Lymphoma; Lymphoproliferative Disorders; Male; Middle Aged; Radiography
PubMed: 6832543
DOI: 10.1007/BF01948094 -
JAAD Case Reports Dec 2022
PubMed: 36386059
DOI: 10.1016/j.jdcr.2022.10.008 -
Skin Health and Disease Feb 2023
PubMed: 36751317
DOI: 10.1002/ski2.135 -
Skin Health and Disease Sep 2021We present a case of a 54-year-old male with multiple myeloma (MM) who presented with widespread pruritic erythematous lesions following ixazomib treatment. This...
We present a case of a 54-year-old male with multiple myeloma (MM) who presented with widespread pruritic erythematous lesions following ixazomib treatment. This occurred after his third cycle of treatment with ixazomib, thalidomide and dexamethasone and was controlled by potent steroids and temporary cessation of ixazomib. The strong correlation between the timeline of the rash, ixazomib treatment and subsequent cessation led to a diagnosis of a drug-induced rash. Skin biopsy histology, immunochemistry and the absence of monoclonal T-cell receptor gene rearrangement further confirmed the diagnosis of a T-cell pseudolymphoma secondary to ixazomib. Ixazomib is an oral proteasome inhibitor used in the treatment of MM. Other proteasome inhibitors have been reported to trigger cutaneous adverse effects. However, to our knowledge, this is the first report of pseudolymphoma following proteasome inhibitor use. Dermatologists should be aware of this potential effect and the possible management pathways such as cessation and dose reduction.
PubMed: 35663138
DOI: 10.1002/ski2.57 -
Annals of Dermatology Dec 2018
PubMed: 33911516
DOI: 10.5021/ad.2018.30.6.725