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Blood Jul 2009Lymphomas of the ocular adnexa are a heterogeneous group of malignancies, composing approximately 1% to 2% of non-Hodgkin lymphomas (NHLs) and 8% of extranodal... (Review)
Review
Lymphomas of the ocular adnexa are a heterogeneous group of malignancies, composing approximately 1% to 2% of non-Hodgkin lymphomas (NHLs) and 8% of extranodal lymphomas. The most common subtype, accounting for up to 80% of cases of primary ocular adnexal lymphoma, is marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) type. In the recent past, there have been significant advances in our understanding of the clinical characteristics, morphology and phenotype, etiology, pathogenesis, diagnosis, natural history, treatment approaches, outcome, and prognostic factors of this disease entity. Novel immunologic and molecular techniques have aided in the distinction between MALT lymphoma and other lymphoproliferative disorders and led to the identification of tissue markers of prognostic significance. Modern imaging modalities provide invaluable tools for accurate staging and treatment planning. Besides radiotherapy and chemotherapy, a variety of new treatment options have emerged in the management of patients with ocular adnexal MALT lymphoma, especially monoclonal antibody therapy and antibiotic therapy against Chlamydia psittaci, which has been associated with the pathogenesis of ocular adnexal lymphomas in some parts of the world. In this review, we present a state-of-the-art summary of ocular adnexal MALT lymphomas.
Topics: Chlamydophila psittaci; Combined Modality Therapy; Eye Neoplasms; Humans; Lymphoma, B-Cell, Marginal Zone; Psittacosis
PubMed: 19372259
DOI: 10.1182/blood-2008-12-195453 -
Journal of Infection in Developing... Apr 2023Psittacosis is a well-recognized zoonotic infectious disorder caused by Chlamydia psittaci (C. psittaci). Human-to-human transmission of C. psittaci has rarely been...
INTRODUCTION
Psittacosis is a well-recognized zoonotic infectious disorder caused by Chlamydia psittaci (C. psittaci). Human-to-human transmission of C. psittaci has rarely been reported previously, especially in the case of healthcare-associated infections.
CASE REPORT
A 32-year-old man was admitted to the intensive care unit with severe pneumonia. An intensive care unit healthcare worker contracted pneumonia 7 days after performing endotracheal intubation on the patient. The first patient, a duck feeder, had been closely exposed to ducks, while the second patient had not been exposed to any birds, mammals or poultry. C. psittaci sequences were obtained by metagenomic next-generation sequencing analyses of bronchial alveolar lavage fluid of both the patients, and they were diagnosed with psittacosis. Therefore, healthcare-associated human-to-human transmission between both cases took place.
CONCLUSIONS
Our findings have implications for managing patients with suspected psittacosis. stringent protective measures are needed to prevent healthcare-associated human-to-human transmission of C. psittaci.
Topics: Animals; Male; Humans; Adult; Psittacosis; Health Facilities; Intensive Care Units; Bronchoalveolar Lavage Fluid; Cross Infection; Mammals
PubMed: 37159883
DOI: 10.3855/jidc.17241 -
Frontiers in Cellular and Infection... 2022To evaluate the value of metagenomic next-generation sequencing (mNGS) for the early diagnosis of psittacosis, and to investigate its epidemiology by whole-genome...
BACKGROUND
To evaluate the value of metagenomic next-generation sequencing (mNGS) for the early diagnosis of psittacosis, and to investigate its epidemiology by whole-genome capture.
METHODS
Twenty-one bronchoalveolar lavage fluid (BALF) and blood samples of 16 psittacosis patients from multiple centers during August 2019 to September 2021 were analyzed retrospectively. mNGS with normal datasets (10 M 75-bp single-end reads after sequencing) and larger datasets (30 M 150-bp paired-end reads after sequencing) as well as quantitative real-time polymerase chain reaction (qPCR) were used to detect the pathogen. Also, whole-genome capture of was applied to draw the phylogenetic tree.
RESULTS
mNGS successfully detected the pathogen in all 16 cases (100%), while qPCR was positive only in 5 out of 10 cases (50%), indicating a significantly higher sensitivity of mNGS than qPCR ( < 0.01). BALF-mNGS performed better than blood-mNGS (16/16 versus 3/5, < 0.05). In addition, larger datasets (the read counts have tripled, and the base number was 12-fold larger compared to clinical mNGS with a normal dataset) of mNGS showed significantly increased contents of human DNA ( < 0.05) and decreased reads per million of the pathogen, suggesting no improvement. Whole-genome capture results of five samples (>60% coverage and >1 depth) were used to construct the phylogenetic tree.
CONCLUSION
Significant advantages of mNGS with normal datasets were demonstrated in early diagnosing psittacosis. It is the first study to use whole-genome capture to analyze epidemiological information.
Topics: High-Throughput Nucleotide Sequencing; Humans; Metagenomics; Phylogeny; Psittacosis; Retrospective Studies; Sensitivity and Specificity
PubMed: 35734579
DOI: 10.3389/fcimb.2022.872899 -
Zhongguo Yi Xue Ke Xue Yuan Xue Bao.... Oct 2022It was generally believed that psittacosis pneumonia (pneumonia caused by ) was rarely combined with pleural effusion and the characteristics of pleural effusion were... (Review)
Review
It was generally believed that psittacosis pneumonia (pneumonia caused by ) was rarely combined with pleural effusion and the characteristics of pleural effusion were rarely reported in the domestic literature.Herein,we reported three cases of pleural effusion due to psittacosis pneumonia,with elevated level of adenosine deaminase and lymphocyte-predominant exudative pleural effusion.Further,we reviewed the psittacosis pneumonia reports with complete clinical and lung imaging data.The imaging manifestations included pulmonary consolidation and common occurrence of a small amount of pleural effusion.The patients of psittacosis pneumonia combined with pleural effusion had severe symptoms,obvious hypoxia,and increased risk of invasive ventilation.
Topics: Humans; Psittacosis; Chlamydophila psittaci; Pleural Effusion; Pneumonia; Lymphocytes
PubMed: 36325793
DOI: 10.3881/j.issn.1000-503X.14760 -
Frontiers in Cellular and Infection... 2022Psittacosis, caused by , is widespread throughout the world. In humans, infection may lead to severe conditions and complications, including sepsis and multiple organ...
INTRODUCTION
Psittacosis, caused by , is widespread throughout the world. In humans, infection may lead to severe conditions and complications, including sepsis and multiple organ failure. We report a cluster of cases caused by in Zhejiang Province, 2021, which led to one death and three cases of hospitalization.
METHODS
The cases were confirmed by nest-PCR, RT-PCR, and mNGS.
RESULTS
The four cases were related and the sequences obtained from the samples were closely correlated with those from Taiwan.
DISCUSSION
This study is the first to report on the case of death from psittacosis in Zhejiang Province, and our results help to assess the disease and recommend effective measures to prevent further spread of .
Topics: Humans; Psittacosis; Chlamydophila psittaci; China; Polymerase Chain Reaction
PubMed: 36590592
DOI: 10.3389/fcimb.2022.1044984 -
Canadian Medical Association Journal Aug 1964Steady improvement in the diagnostic appraisal of obscure pulmonary and mediastinal disease has permitted more intelligent treatment, better prognosis, and where...
Steady improvement in the diagnostic appraisal of obscure pulmonary and mediastinal disease has permitted more intelligent treatment, better prognosis, and where necessary more accurate assessment of compensability. Open lung biopsy is designed to obtain material for pathological study when there is no pleural, mediastinal, or airway lesion on which to base a working diagnosis.A study of 54 patients in whom lung biopsy was performed at the Toronto General Hospital and Weston Sanatorium is reported. A positive tissue diagnosis was obtained in approximately 75%. The procedure is considered relatively innocuous if sensible selection is exercised to exclude patients with terminal disease, particularly that associated with severe cardiorespiratory insufficiency. No major complications occurred in this series. It is concluded that open lung biopsy might reasonably receive much wider application than in the past in cases in which a definite diagnosis cannot otherwise be made.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Biopsy; Bronchioles; Carcinoma; Diagnosis, Differential; Eosinophilic Granuloma; Humans; Lung; Lung Diseases; Lung Neoplasms; Melanoma; Pathology; Psittacosis; Pulmonary Fibrosis; Radiography, Thoracic; Sarcoidosis; Silicotuberculosis; Tuberculosis; Tuberculosis, Pulmonary
PubMed: 14180532
DOI: No ID Found -
The Indian Journal of Medical Research Apr 2021
Topics: Humans; Lung; Psittacosis; Tomography, X-Ray Computed
PubMed: 35435351
DOI: 10.4103/ijmr.IJMR_1793_19 -
Frontiers in Cellular and Infection... 2023is the causative agent of psittacosis in humans, while its rapid identification is hampered due to the lack of specificity of laboratory testing methods.
BACKGROUND
is the causative agent of psittacosis in humans, while its rapid identification is hampered due to the lack of specificity of laboratory testing methods.
CASE PRESENTATION
This study reports four cases of infection after contact with a domestic parrot, all belonging to the same family. Common manifestations like fever, cough, headache, nausea, and hypodynamia appeared in the patients. Metagenomic next-generation sequencing (mNGS) aided the etiological diagnosis of psittacosis, revealing 58318 and 7 sequence reads corresponding to in two cases. The detected was typed as ST100001 in the Multilocus-sequence typing (MLST) system, a novel strain initially reported. Based on the results of pathogenic identification by mNGS, the four patients were individually, treated with different antibiotics, and discharged with favorable outcomes.
CONCLUSION
In diagnosing psittacosis caused by a rare agent, mNGS provides rapid etiological identification, contributing to targeted antibiotic therapy and favorable outcomes. This study also reminds clinicians to raise awareness of psittacosis when encountering family members with a fever of unknown origin.
Topics: Humans; Psittacosis; Chlamydophila psittaci; Multilocus Sequence Typing; Anti-Bacterial Agents; High-Throughput Nucleotide Sequencing
PubMed: 37799338
DOI: 10.3389/fcimb.2023.1249225 -
New Microbes and New Infections Jan 2014Following a large outbreak of community-acquired psittacosis in 2002 in residents of the Blue Mountains, New South Wales, Australia, we reviewed new cases in this area...
Following a large outbreak of community-acquired psittacosis in 2002 in residents of the Blue Mountains, New South Wales, Australia, we reviewed new cases in this area over a 7-year period from 2003 to 2009. Using the 2010 criteria from the Centers for Disease Control National Notifiable Diseases Surveillance System, 85 patients with possible psittacosis were identified, of which 48 were identified as definite or probable infection. Clinical features of these cases are summarized. In addition to Chlamydia-specific serology, specimens, where available, underwent nucleic acid testing for chlamydial DNA using real-time PCR. Chlamydophila psittaci DNA was detected in samples from 23 patients. Four of 18 specimens were culture positive. This is the first description of endemic psittacosis, and is characterized in this location by community-acquired psittacosis resulting from inadvertent exposure to birds. The disease is likely to be under-diagnosed, and may often be mistaken for gastroenteritis or meningitis given the frequency of non-respiratory symptoms, particularly without a history of contact with birds. Clinical characteristics of endemic and outbreak-associated cases were similar. The nature of exposure, risk factors and reasons for the occurrence of outbreaks of psittacosis require further investigation.
PubMed: 25356332
DOI: 10.1002/2052-2975.29 -
Emerging Infectious Diseases 1996The recognition of genital chlamydial infection as an important public health problem was made first by the recognition of its role in acute clinical syndromes, as well... (Review)
Review
The recognition of genital chlamydial infection as an important public health problem was made first by the recognition of its role in acute clinical syndromes, as well as in serious reproductive and ocular complications, and secondly by our awareness of its prevalence when diagnostic tests became widely accessible. The recent availability of effective single dose oral antimicrobial therapy and sensitive molecular amplification tests that allow the use of noninvasive specimens for diagnosis and screening is expected to have a major impact in reducing the prevalence of disease in the next decade. Clinical manifestations associated with Chlamydia pneumoniae infection continue to emerge beyond respiratory illness. In particular, its association with atherosclerosis deserves further investigation. Chlamydia pecorum, a pathogen of ruminants, was recently recognized as a new species. The continued application of molecular techniques will likely elucidate an expanding role for chlamydiae in human and animal diseases, delineate the phylogenetic relationships among chlamydial species and within the eubacteria domain, and provide tools for detection and control of chlamydial infections.
Topics: Anti-Bacterial Agents; Arteriosclerosis; Asthma; Azithromycin; Bacterial Outer Membrane Proteins; Chlamydia Infections; Chlamydia trachomatis; Chlamydophila pneumoniae; Chlamydophila psittaci; Clarithromycin; Host-Parasite Interactions; Humans; Polymorphism, Genetic; Psittacosis; Tetracycline
PubMed: 8969247
DOI: 10.3201/eid0204.960406