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Actas Dermo-sifiliograficas Apr 2015Darwinian medicine, or evolutionary medicine, regards some pathological conditions as attempts by the organism to solve a problem or develop defense mechanisms. At... (Review)
Review
Darwinian medicine, or evolutionary medicine, regards some pathological conditions as attempts by the organism to solve a problem or develop defense mechanisms. At certain stages of human evolution, some diseases may have conferred a selective advantage. Psoriasis is a high-penetrance multigenic disorder with prevalence among whites of up to 3%. Psoriatic lesions have been linked with enhanced wound-healing qualities and greater capacity to fight infection. Leprosy, tuberculosis, and infections caused by viruses similar to human immunodeficiency virus have been postulated as environmental stressors that may have selected for psoriasis-promoting genes in some human populations. The tendency of patients with severe psoriasis to develop metabolic syndrome may reflect the body's attempt to react to environmental stresses and warning signs by triggering insulin resistance and fat storage.
Topics: Adaptation, Biological; Biological Evolution; Birth Weight; Energy Metabolism; Ethnicity; Gene-Environment Interaction; Genetic Fitness; Genetic Predisposition to Disease; Humans; Metabolic Syndrome; Penetrance; Psoriasis; Selection, Genetic; Skin Diseases, Infectious; Wound Healing
PubMed: 25129580
DOI: 10.1016/j.ad.2014.06.009 -
Frontiers in Immunology 2022Psoriasis is a chronic papulosquamous skin disease with an autoimmune pathogenic traits and strong genetic predisposition. In the past few decades, with the rapid... (Review)
Review
Psoriasis is a chronic papulosquamous skin disease with an autoimmune pathogenic traits and strong genetic predisposition. In the past few decades, with the rapid development of molecular biology and cell biology, the inherent pathogenesis of psoriasis has been gradually elucidated, in which cytokine inflammatory loops, cell signaling pathways, and epigenetic factors such as miRNAs have been demonstrated to play important roles in regulating the development and progression of psoriasis. More importantly, understanding the pathogenesis of psoriasis has promoted the development of effective treatment for psoriasis. In this review, we systemically summarized the molecular mechanisms regulating the development and progression psoriasis, introduced various therapeutics used for clinical psoriasis therapy, and highlighted the recent advances in nanoparticles (NPs)-mediated drug delivery for psoriasis treatment.
Topics: Humans; Skin; Psoriasis; MicroRNAs; Genetic Predisposition to Disease; Nanoparticles
PubMed: 36618400
DOI: 10.3389/fimmu.2022.1089262 -
Anais Brasileiros de Dermatologia 2015Psoriasis is a chronic inflammatory systemic disease. Evidence shows an association of psoriasis with arthritis, depression, inflammatory bowel disease and... (Review)
Review
Psoriasis is a chronic inflammatory systemic disease. Evidence shows an association of psoriasis with arthritis, depression, inflammatory bowel disease and cardiovascular diseases. Recently, several other comorbid conditions have been proposed as related to the chronic inflammatory status of psoriasis. The understanding of these conditions and their treatments will certainly lead to better management of the disease. The present article aims to synthesize the knowledge in the literature about the classical and emerging comorbidities related to psoriasis.
Topics: Arthritis, Psoriatic; Cardiovascular Diseases; Comorbidity; Humans; Life Style; Metabolic Syndrome; Psoriasis; Quality of Life; Risk Factors; Severity of Illness Index
PubMed: 25672294
DOI: 10.1590/abd1806-4841.20153038 -
International Journal of Molecular... Apr 2022Skin is an important organ that mainly functions as a barrier. Skin diseases can damage a person's self-confidence and reduce their willingness to socialize, as well as... (Review)
Review
Skin is an important organ that mainly functions as a barrier. Skin diseases can damage a person's self-confidence and reduce their willingness to socialize, as well as their social behavior and willingness. When the skin appearance is abnormal, in addition to affecting the quality of life, it often leads to personal, social, and psychological dysfunction and even induces depression. Psoriasis and atopic dermatitis are common chronic skin diseases. Their prevalence in the world is 3-10%, and there is an increasing trend year by year. These congenital or acquired factors cause the dysfunction of the immune system and then destroy the barrier function of the skin. Because these patients are flooded with a variety of inflammatory mediators, this causes skin cells to be in chronic inflammation. Therefore, psoriasis and atopic dermatitis are also considered systemic chronic inflammatory diseases. In the healthcare systems of developed countries, it is unavoidable to spend high costs to relieve symptoms of psoriasis and atopic dermatitis patients, because psoriasis and atopic dermatitis have a great influence on individuals and society. Giving a lot of attention and developing effective treatment methods are the topics that the medical community must work on together. Therefore, we used a narrative review manuscript to discuss pathogenesis, clinical classification, incidence, and treatment options, including topical medication, systemic therapeutics, immunosuppressive medication for psoriasis, and atopic dermatitis, as well as also comparing the differences between these two diseases. We look forward to providing readers with comprehensive information on psoriasis and atopic dermatitis through this review article.
Topics: Chronic Disease; Dermatitis, Atopic; Humans; Psoriasis; Quality of Life; Skin; Skin Diseases
PubMed: 35563285
DOI: 10.3390/ijms23094898 -
The Journal of Investigative Dermatology Mar 2017This article highlights recent advances in the immunology, epidemiology, and genetics/genomics of psoriasis. Advances sometimes generate more questions, and this article... (Review)
Review
This article highlights recent advances in the immunology, epidemiology, and genetics/genomics of psoriasis. Advances sometimes generate more questions, and this article makes an attempt to point out where controversies might exist in the literature. Many of the articles mentioned were published in the Journal of Investigative Dermatology, but many articles from the broader scientific literature are also cited, to provide context and to add further validity for some of these key findings. Among the themes we explore are the identification of antigens in psoriasis, the co-morbidities of psoriasis, and novel integrative approaches to genome-wide association studies.
Topics: Antimicrobial Cationic Peptides; Cardiovascular Diseases; Dermatology; Genome-Wide Association Study; Genomics; Health Services Accessibility; Humans; Inflammation; Precision Medicine; Psoriasis
PubMed: 28063651
DOI: 10.1016/j.jid.2016.11.007 -
Australian Family Physician Jul 2011Psoriasis is one of the more common rashes presenting to general practice. (Review)
Review
BACKGROUND
Psoriasis is one of the more common rashes presenting to general practice.
OBJECTIVE
This article outlines the assessment and management of psoriasis in the general practice setting.
DISCUSSION
Careful clinical assessment will usually lead to a diagnosis of psoriasis. Management starts with education, lifestyle measures and general skin care measures. Although topical steroids are the mainstay of treatment, other topical options are outlined and treatment options in difficult locations are considered. The potential indications for referral and systemic therapies are also considered.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents; Diagnosis, Differential; Humans; Medical History Taking; Physical Examination; Psoriasis; Referral and Consultation
PubMed: 21743850
DOI: No ID Found -
Current Atherosclerosis Reports Sep 2021Psoriasis is a chronic inflammatory skin condition that is associated with increased cardiovascular risk compared to those without psoriasis. This review will cover... (Review)
Review
PURPOSE OF REVIEW
Psoriasis is a chronic inflammatory skin condition that is associated with increased cardiovascular risk compared to those without psoriasis. This review will cover emerging mechanisms of cardiovascular risk, key pathways targeted with biologic therapies, and the current evidence on therapies to modulate this risk in patients with psoriasis.
RECENT FINDINGS
Recent scientific work has highlighted mechanisms that contribute to this enhanced risk, including the role of vascular endothelial dysfunction, platelet activation, dyslipidemia, and increased cardiometabolic comorbidities. Newer biologic and targeted synthetic therapies have transformed psoriasis treatment with high rates of clinical remission and durable skin disease control now possible. Epidemiological evidence suggests that many of these therapies may lower cardiovascular risk in psoriasis, although prospective interventional data is lacking (or mixed). Recently, caution has also been raised that some treatments may negatively affect cardiovascular risk. Overall, the current data suggests a positive or neutral ability to reduce cardiovascular risk for TNF, IL-17A, and IL-12/23p40 inhibitors, but current evidence remains conflicting for anti-IL-23/p19 and JAK inhibitors. More studies that include prospective cohorts, larger number of patients, treatment duration, and validated surrogate outcomes are needed to better evaluate the role of biologic therapies on cardiovascular risk in psoriasis.
Topics: Cardiovascular Diseases; Comorbidity; Humans; Prospective Studies; Psoriasis
PubMed: 34468875
DOI: 10.1007/s11883-021-00963-y -
Revista Portuguesa de Cardiologia :... Feb 2014Psoriasis is a common chronic inflammatory disease associated with serious comorbidities. In recent years, increased mortality due to cardiovascular disease (myocardial... (Review)
Review
Psoriasis is a common chronic inflammatory disease associated with serious comorbidities. In recent years, increased mortality due to cardiovascular disease (myocardial infarction and stroke) has been documented in patients with severe psoriasis. Patients with psoriasis have a higher prevalence of traditional cardiovascular risk factors such as diabetes, hypertension, dyslipidemia and obesity, but it has been suggested that the chronic inflammatory nature of psoriasis is also a contributing and potentially an independent risk factor for the development of cardiovascular disease. The authors highlight the need for early identification and treatment of psoriasis-related comorbidities and cardiovascular disease, as well as effective treatment of psoriasis, in order to reduce the underlying systemic inflammation, and also the importance of a multidisciplinary approach of severe psoriasis patients to optimize the diagnosis, monitoring and treatment of various comorbidities, so as to prevent cardiovascular events.
Topics: Cardiovascular Diseases; Humans; Psoriasis; Risk Factors
PubMed: 24525359
DOI: 10.1016/j.repc.2013.06.017 -
Anais Brasileiros de Dermatologia 2022Generalized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background,... (Review)
Review
Generalized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background, eventually associated with psoriasis vulgaris. Classically, it manifests as a potentially severe systemic picture and demands prompt diagnosis and intervention. The duration of each flare-up and intervals between the pustular episodes is extremely variable. Recently, genetic abnormalities have been identified mainly in the familial and early variants of this disease. The therapeutic arsenal is limited; however, new drugs being evaluated aim to control both pustular flare-ups and disease recurrences.
Topics: Acute Disease; Chronic Disease; Exanthema; Humans; Psoriasis; Skin Diseases, Vesiculobullous
PubMed: 34838431
DOI: 10.1016/j.abd.2021.05.011 -
Acta Dermato-venereologica Nov 2021Psoriasis is an inflammatory, immune-mediated disease that is frequently associated with psychological comorbidities such as depression. The stigma patients feel because...
Psoriasis is an inflammatory, immune-mediated disease that is frequently associated with psychological comorbidities such as depression. The stigma patients feel because of the appearance of their skin may contribute to the high psycho-social burden of psoriasis. However, there is emerging evidence that overlapping biological mechanisms are, to a substantial degree, responsible for the close interaction between psoriasis and depression. Increased proinflammatory mediators, such as C-reactive protein or interleukin-6, are present in both psoriasis and depression, indicating that inflammation may represent a pathophysiological link between the diseases. Anti-inflammatory biologic therapies treat the clinical manifestations of psoriasis, but might also play a significant role in reducing associated depressive symptoms in patients with psoriasis. Comparison between single studies focusing on the change in depressive symptoms in psoriasis is limited by inconsistency in the depression screening tools applied.
Topics: Anti-Inflammatory Agents; Depression; Humans; Inflammation; Psoriasis; Skin
PubMed: 34806760
DOI: 10.2340/actadv.v101.565