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British Medical Journal Apr 1965
Topics: Humans; Prognosis; Psychosurgery
PubMed: 14270183
DOI: No ID Found -
Proceedings of the Royal Society of... Sep 1960
Topics: Psychosurgery
PubMed: 13761675
DOI: No ID Found -
British Medical Journal Nov 1955
Topics: Electroconvulsive Therapy; Humans; Psychosurgery; Psychotherapy; Psychotic Disorders
PubMed: 13269862
DOI: 10.1136/bmj.2.4951.1320 -
British Medical Journal Nov 1974
Topics: Agoraphobia; Anti-Anxiety Agents; Benzodiazepines; Desensitization, Immunologic; Humans; Phobic Disorders; Psychosurgery; Psychotherapy
PubMed: 4154125
DOI: No ID Found -
British Medical Journal Nov 1953
Topics: Humans; Psychosurgery
PubMed: 13094129
DOI: No ID Found -
British Medical Journal Aug 1948
Topics: Psychosurgery
PubMed: 18939130
DOI: No ID Found -
Neuropsychiatric Disease and Treatment 2015
PubMed: 25897232
DOI: 10.2147/NDT.S74875 -
Frontiers in Neuroscience 2023Limbic surgery is one of the most attractive and retaken fields of functional neurosurgery in the last two decades. Psychiatric surgery emerged from the incipient work... (Review)
Review
Limbic surgery is one of the most attractive and retaken fields of functional neurosurgery in the last two decades. Psychiatric surgery emerged from the incipient work of Moniz and Lima lesioning the prefrontal cortex in agitated patients. Since the onset of stereotactic and functional neurosurgery with Spiegel and Wycis, the treatment of mental diseases gave attention to refractory illnesses mainly with the use of thalamotomies. Neurosis and some psychotic symptoms were treated by them. Several indications when lesioning the brain were included: obsessive-compulsive disorder, depression, and aggressiveness among others with a diversity of targets. The indiscriminately use of anatomical sites without enough scientific evidence, and uncertainly defined criteria for selecting patients merged with a deficiency in ethical aspects, brought a lack of procedures for a long time: only select clinics allowed this surgery around the world from 1950 to the 1990s. In 1999, Nuttin et al. began a new chapter in limbic surgery with the use of Deep Brain Stimulation, based on the experience of pain, Parkinson's disease, and epilepsy. The efforts were focused on different targets to treat depression and obsessive-compulsive disorders. Nevertheless, other diseases were added to use neuromodulation. The goal of this article is to show the new opportunities to treat neuropsychiatric diseases.
PubMed: 37274213
DOI: 10.3389/fnins.2023.1167244 -
Stereotactic and Functional Neurosurgery 2014
Topics: Female; Humans; Internal Capsule; Magnetic Resonance Imaging; Male; Psychosurgery; Schizophrenia; Schizophrenic Psychology; Stereotaxic Techniques
PubMed: 25376376
DOI: 10.1159/000366005 -
Indian Journal of Psychiatry Jan 2019Despite advancements in pharmacotherapeutic and behavioral interventions, a substantial proportion of patients with obsessive-compulsive disorder (OCD) continue to have... (Review)
Review
Despite advancements in pharmacotherapeutic and behavioral interventions, a substantial proportion of patients with obsessive-compulsive disorder (OCD) continue to have disabling and treatment-refractory illness. Neurosurgical interventions, including ablative procedures and deep brain stimulation (DBS), have emerged as potential treatment options in this population. We review the recent literature on contemporary surgical options for OCD, focusing on clinical aspects such as patient selection, presurgical assessment, and safety and effectiveness of these procedures. Given the invasiveness and limited evidence, these procedures have been performed in carefully selected patients with severe, chronic, and treatment-refractory illness. Along with informed consent, an independent review by a multidisciplinary team is mandated in many centers. Both ablative procedures and DBS have been found to be helpful in around half the patients, with improvement observed months after the procedure. Various targets have been proposed for either procedure, based on the dominant corticostriatal model of OCD. There is no strong evidence to recommend one procedure over the other. Hence, the choice of procedure is often based on the factors such as affordability, expertise, and reversibility of adverse effects. Surgery is not recommended as a standalone treatment but should be provided as part of a comprehensive package including medications and psychotherapeutic interventions. Available evidence suggest that the benefits of the procedure outweigh the risks in a treatment-refractory population. Advances in neurosurgical techniques and increasing knowledge of neurobiology are likely to bring about further progress in the efficacy, safety, and acceptability of the procedures.
PubMed: 30745680
DOI: 10.4103/psychiatry.IndianJPsychiatry_523_18