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British Medical Journal Apr 1956
Topics: Central Nervous System Agents; Central Nervous System Stimulants; Mental Disorders; Psychosurgery; Psychotherapy
PubMed: 13304397
DOI: No ID Found -
Frontiers in Integrative Neuroscience 2022In this review, we describe the evolution of modern ablative surgery for intractable psychiatric disease, from the original image-guided cingulotomy procedure described... (Review)
Review
In this review, we describe the evolution of modern ablative surgery for intractable psychiatric disease, from the original image-guided cingulotomy procedure described by Ballantine, to the current bilateral anterior cingulotomy using MRI-guided stereotactic techniques. Extension of the single lesion bilateral cingulotomy to the extended bilateral cingulotomy and subsequent staged limbic leucotomy (LL) is also discussed. Other ablative surgeries for psychiatric disease including subcaudate tractotomy (SCT) and anterior capsulotomy (AC) using modern MRI-guided ablative techniques, as well as radiosurgical capsulotomy, are described. Finally, the potential emerging role of MR-guided focused ultrasound (MRgFUS) for treating conditions such as major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) is discussed.
PubMed: 35464603
DOI: 10.3389/fnint.2022.797533 -
British Medical Journal Dec 1979
Topics: England; Humans; Psychosurgery; Radio
PubMed: 519489
DOI: No ID Found -
Proceedings of the Royal Society of... Mar 1973
Review
Topics: Amitriptyline; Anthracenes; Antidepressive Agents; Anxiety; Diazepam; Dibenzazepines; Humans; Lactates; Limbic System; Monoamine Oxidase Inhibitors; Perphenazine; Psychosurgery
PubMed: 4572667
DOI: No ID Found -
Neurologia I Neurochirurgia Polska 2021Deep brain stimulation (DBS) has achieved substantial success as a treatment for movement disorders such as Parkinson's Disease (PD), essential tremor (ET), and... (Review)
Review
INTRODUCTION
Deep brain stimulation (DBS) has achieved substantial success as a treatment for movement disorders such as Parkinson's Disease (PD), essential tremor (ET), and dystonia. More recently, a limited number of basic and clinical studies have indicated that DBS of the nucleus accumbens (NAc) and other neighbouring structures of the reward circuit may be an effective intervention for patients with treatment-refractory addiction.
MATERIAL AND METHODS
We performed a structured literature review of human studies of DBS for addiction outlining the clinical efficacy and adverse events. We found 14 human studies targeting mostly the NAc with neighbouring structures such as anterior limb of the internal capsule (ALIC). Five studies including 12 patients reported the outcomes for alcohol dependence. Nine studies including 18 patients reported the outcomes for addictions to various psychoactive substances. The most common indication was addiction to heroin, found in 13 patients, followed by methamphetamine, 3 patients, cocaine, one patient, and polysubstance drug abuse in one patient.
CONCLUSIONS
The limited clinical data available indicates that DBS may be a promising therapeutic modality for the treatment of intractable addiction. In general, the safety profile of DBS in patients with addiction is good. Based on the data published in the literature, the NAc is the most often targeted, and is probably the most effective, structure of the reward circuit in the treatment of addiction in humans. Given the ever-expanding understanding of the psychosurgery of addiction, DBS could in the future be a treatment option for patients suffering from intractable addictive disorders.
Topics: Deep Brain Stimulation; Humans; Internal Capsule; Nucleus Accumbens; Substance-Related Disorders; Treatment Outcome
PubMed: 34633060
DOI: 10.5603/PJNNS.a2021.0065 -
Turkish Neurosurgery Jul 2009The modern age of psychosurgery can be said to have started with Moniz and Lima. Freeman and Watts subsequently revised and popularised the lobotomy procedure. Moniz...
The modern age of psychosurgery can be said to have started with Moniz and Lima. Freeman and Watts subsequently revised and popularised the lobotomy procedure. Moniz shared the 1949 Nobel Prize for medicine or physiology for his discovery of the therapeutic value of leucotomy in certain psychoses, which accelerated the worldwide popularisation of lobotomy, particularly during the years from 1948 to 1953. In Turkey, psychosurgical interventions were first performed in the early 1950s, and were applied in almost 400 cases. These operations gradually ceased after the discovery and worldwide clinic applications of a modern antipsychotic drug named Chlorpromazine in 1950s, paralleling a similar trend in other countries. Our paper reviews the clinical, psychometric and histopathological results of psychosurgery performed in Turkey in the 1950s.
Topics: History, 20th Century; Humans; Mental Disorders; Psychosurgery; Turkey
PubMed: 19621302
DOI: No ID Found -
Frontiers in Human Neuroscience 2014
Review
PubMed: 24634651
DOI: 10.3389/fnhum.2014.00124 -
British Medical Journal Sep 1962
Topics: Biometry; Criminal Psychology; Humans; Prisons; Psychosurgery
PubMed: 13914574
DOI: 10.1136/bmj.2.5307.789 -
British Medical Journal Sep 1971
Topics: Anxiety; Depression; Frontal Lobe; Humans; Methods; Obsessive-Compulsive Disorder; Phobic Disorders; Prospective Studies; Psychosurgery; Schizophrenia
PubMed: 5569974
DOI: No ID Found -
Proceedings of the Royal Society of... Nov 1973
Topics: Adult; Amygdala; Classification; Criminal Psychology; Epilepsy; Follow-Up Studies; Humans; Male; Psychiatric Status Rating Scales; Psychosurgery; Violence
PubMed: 4777038
DOI: No ID Found