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Journal of Plastic, Reconstructive &... Dec 2010
Topics: Blepharoptosis; Eyelids; Humans; Minimally Invasive Surgical Procedures; Ophthalmologic Surgical Procedures; Suture Techniques
PubMed: 20646977
DOI: 10.1016/j.bjps.2010.05.028 -
Eye (London, England) Jul 2013The purpose of this study is to evaluate the role of apoptosis in the pathogenesis of blepharoptosis.
PURPOSE
The purpose of this study is to evaluate the role of apoptosis in the pathogenesis of blepharoptosis.
PATIENTS AND METHODS
Forty-five eyelids of 43 consecutive patients (16 female, 27 males) that underwent levator resection surgery for ptosis correction were included in the study. Twenty-six of the eyelids had congenital myogenic ptosis and 19 had aponeurotic ptosis. Levator palpebrae superioris function and height of the vertical palpebral fissure were measured in all patients. After levator resection surgery, the distal part of the levator aponeurosis was fixed and sent for evaluation. Apoptotic cells were detected using Apop Tag Plus Peroxidase In Situ Apoptosis Detection Kit.
RESULTS
The mean levator palpebrae superioris function was 8.4 mm (range 5-10 mm) in congenital ptosis group and 12.1 mm (range 10-17 mm) in the aponeurotic ptosis group. The mean height of the vertical palpebral fissure in patients with congenital ptosis and aponeurotic ptosis were 6.5 mm (range 5-9 mm) and 6.1 mm (3-9 mm), respectively. The mean apoptotic index of congenital ptosis and aponeurotic ptosis were 27.3 (16-39) and 29.8 (18-41), respectively. There was no statistically significant difference between congenital and aponeurotic ptosis groups in a mean apoptotic index (P<0.05). Apoptotic index was not correlated with age, levator palpebrae superioris function, palpebral fissure height, and lid crease height in two groups.
CONCLUSION
We found no statistically significant difference between two subtypes of blepharoptosis regarding apoptosis. According to this study, apoptosis seems to have no significant role in the development of aponeurotic blepharoptosis.
Topics: Adolescent; Adult; Apoptosis; Blepharoptosis; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Oculomotor Muscles; Young Adult
PubMed: 23598678
DOI: 10.1038/eye.2013.73 -
Medicina (Kaunas, Lithuania) Mar 2023: Previous studies on ptosis recurrence after correction surgery have tended to focus on postoperative complications, surgical methods and suspension materials, few have...
: Previous studies on ptosis recurrence after correction surgery have tended to focus on postoperative complications, surgical methods and suspension materials, few have mentioned refractive error. This research is to investigate the potential relation between refractive error and recurrence after correction surgery in pediatric patients with simple congenital ptosis. : We conducted a retrospective analysis of data from patients with simple congenital ptosis who were treated at Zhongshan Ophthalmic Center (ZOC) between 2017 and 2020. In total, 111 eyelids of 85 patients without surgery-related complications who underwent frontalis muscle flap suspension (FMFS) for simple congenital ptosis were included. Postoperative changes in eyelid height were assessed. Cycloplegic refraction was assessed before surgery and during the follow-up period (every 3 months after surgery). Recurrence in the postoperative period was defined as a marginal reflex distance 1 (MRD1) of <1 mm. : There were 16 recurrence and 69 non-recurrence cases, with no statistically significant differences, in terms of patient age at the time of surgery, patient sex, or preoperative MRD1, between the recurrence and non-recurrence groups. The postoperative cylindrical diopter (adjusted odds ratio [OR] = 0.432, = 0.005), laterality (adjusted OR = 0.202, = 0.006), and preoperative MRD1 (adjusted OR = 0.617, = 0.019) were associated with ptosis recurrence after surgery. Differences between the recurrence and non-recurrence groups in spherical diopter and spherical equivalent (SE) before and after surgery were not statistically significant. In addition, preoperative refractive error and postoperative spherical diopter were not significantly associated with ptosis recurrence after correction surgery. : Ptosis recurrence after FMFS in pediatric cases of congenital ptosis is associated with refractive error. Timely refractive correction and amblyopia treatment may help to reduce ptosis recurrence.
Topics: Child; Humans; Retrospective Studies; Oculomotor Muscles; Blepharoptosis; Eyelids; Refractive Errors; Treatment Outcome
PubMed: 36984631
DOI: 10.3390/medicina59030630 -
BMJ Case Reports Mar 2021A 73-year-old white man presents with left-sided ptosis and diplopia in the absence of ophthalmoplegia, with left hemibody paresthesia. He reports intermittent dysphagia...
A 73-year-old white man presents with left-sided ptosis and diplopia in the absence of ophthalmoplegia, with left hemibody paresthesia. He reports intermittent dysphagia and dizziness for 1 month and diarrhoea for 2 months. Serum and electrodiagnostic studies confirmed the diagnosis of myasthenia gravis. This case highlights the non-classic presentation of myasthenia gravis in the absence of ophthalmoplegia with a unique unexplained hemisensory deficit.
Topics: Aged; Blepharoptosis; Deglutition Disorders; Diplopia; Humans; Male; Myasthenia Gravis; Ophthalmoplegia
PubMed: 33731400
DOI: 10.1136/bcr-2020-237405 -
Turkish Journal of Ophthalmology Dec 2020To evaluate periorbital tissue alterations including eyelid laxity and eyelash ptosis in patients with obstructive sleep apnea syndrome (OSAS).
OBJECTIVES
To evaluate periorbital tissue alterations including eyelid laxity and eyelash ptosis in patients with obstructive sleep apnea syndrome (OSAS).
MATERIALS AND METHODS
Based on polysomnography, 96 eyes of 48 patients with moderate/severe OSAS (Group 1) and 44 eyes of 22 patients with simple snoring (Group 2) were enrolled. Comprehensive eye examination along with eyelid laxity measurements including vertical and anterior distraction, presence of dermatochalasis, interpalpebral distance, and levator function were assessed. The presence and severity of eyelash ptosis were also noted.
RESULTS
The mean ages of Group 1 and Group 2 were 49.9±11.4 (range: 26-67) and 50.6±8.9 (range: 27-69) years, respectively (p=0.557). The mean vertical and anterior distraction distances in Group 1 (13.3±4.1 [range, 6-27] mm and 7.4±2.1 [range, 3-13.5] mm, respectively) were significantly higher than in Group 2 (p<0.05). Dermatochalasis and eyelash ptosis were found to be significantly more frequent in Group 1 (52.1% and 81.3%, respectively). The severity of eyelash ptosis was also higher in OSAS (p<0.05). No significant difference in interpalpebral distance or levator muscle function was detected.
CONCLUSION
In patients with severe OSAS, eyelid laxity was more prominent and eyelash ptosis was more frequent and severe.
Topics: Blepharoptosis; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Polysomnography; Prospective Studies; Severity of Illness Index; Sleep Apnea, Obstructive
PubMed: 33389936
DOI: 10.4274/tjo.galenos.2020.35033 -
Ophthalmology Jun 2011To report the incidence and demographics of childhood ptosis diagnosed over a 40-year period in a well-defined population. (Comparative Study)
Comparative Study
PURPOSE
To report the incidence and demographics of childhood ptosis diagnosed over a 40-year period in a well-defined population.
DESIGN
Retrospective, population-based cohort study.
PARTICIPANTS
Patients (<19 years) diagnosed with childhood ptosis and residents of Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004.
METHODS
The medical records of all potential patients identified by the Rochester Epidemiology Project were reviewed.
MAIN OUTCOME MEASURES
Calculated annual age- and gender-specific incidence rates and demographic information.
RESULTS
A total of 107 children were diagnosed with ptosis during the 40-year period, yielding an incidence of 7.9 per 100000 younger than 19 years (95% confidence interval [CI], 6.4-9.5). Ninety-six (89.7%) of the 107 had congenital-onset disease. Eighty-one (75%) of the 107 had simple congenital ptosis, yielding a birth prevalence of 1 in 842 births. A family history of childhood ptosis was present in 12% of queried patients with simple congenital ptosis. Three (4%) of the simple congenital ptosis cases were bilateral and 55 (68%) of the unilateral cases involved the left upper eyelid (95% CI, 57%-78%; P<0.001).
CONCLUSIONS
Childhood ptosis was diagnosed in 7.9 per 100000 patients younger than 19 years (95% CI, 6.4-9.5). Simple congenital ptosis was the most prevalent form, occurring in 1 in 842 births, and was significantly more likely to involve the left side.
FINANCIAL DISCLOSURE(S)
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Topics: Age Distribution; Blepharoptosis; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Incidence; Male; Minnesota; Retrospective Studies; Sex Distribution
PubMed: 21496927
DOI: 10.1016/j.ophtha.2010.10.026 -
BMC Ophthalmology Jul 2022The study aimed to investigate the difference in refractive status and ocular parameters between ptotic and fellow eyes in patients with unilateral congenital ptosis.
BACKGROUND
The study aimed to investigate the difference in refractive status and ocular parameters between ptotic and fellow eyes in patients with unilateral congenital ptosis.
METHODS
Thirty patients (53% males, age 22.00 ± 11.41 years) with unilateral congenital ptosis diagnosed and treated at the First Affiliated Hospital of Sun-yat Sen University were enrolled and underwent detailed refractive examinations from March 2019 to February 2022. Ocular biometric measurements were performed by an IOL Master 700 biometer. The differences in refractive error characteristics, best-corrected visual acuity (BCVA), and ocular parameters including axial length (AL), central corneal thickness (CCT), aqueous depth (AQD), anterior chamber depth (ACD), lens thickness (LT), and keratometry values between ptotic and fellow eyes were analysed.
RESULTS
A lower BCVA (logMAR, median (IQR), 0.00 (- 0.13,0.00), P = 0.009) and a higher incidence of amblyopia (n (%), 7(23%), P = 0.016) were observed in ptotic eyes. The CCT of ptotic eyes was greater than that of fellow eyes (mean ± SD, 539.83 ± 26.73 μm, P < 0.001). The keratometry values at the flat axis (K1) and mean corneal power (Km) were smaller in ptotic eyes (mean ± SD, 42.11 ± 1.49 D, 42.68 ± 1.52 D, respectively, both P = 0.001). There was no significant difference in AL between ptotic and fellow eyes.
CONCLUSIONS
Congenital ptosis influences ocular parameters, mainly causing a thicker and flatter cornea. Patients with unilateral congenital ptosis might have lower BCVA in the ptotic eyes.
Topics: Adolescent; Adult; Amblyopia; Blepharoptosis; Child; Cornea; Female; Humans; Male; Refraction, Ocular; Refractive Errors; Young Adult
PubMed: 35780098
DOI: 10.1186/s12886-022-02511-x -
Eye (London, England) Apr 2023To evaluate the outcomes of combined levator resection and frontalis muscle advancement for surgical management of recurrent severe congenital ptosis.
BACKGROUND
To evaluate the outcomes of combined levator resection and frontalis muscle advancement for surgical management of recurrent severe congenital ptosis.
DESIGN
Retrospective, nonrandomized interventional case series.
METHODS
A retrospective review was performed of patients who underwent combined levator resection and frontalis muscle advancement for recurrent congenital ptosis between 2017 and 2020. Inclusion criteria were levator function of 4 mm or less and margin reflex distance 1 (MRD1) of 0 mm or less. Main outcome measures were postoperative MRD 1, lagophthalmos, lash angle, and grades of eyelid contour and crease. The outcomes were assessed by reviewing medical charts and photographs.
RESULTS
Thirty-one patients (35 eyelids) met the inclusion criteria. The mean preoperative MRD1 was -1.14 ± 1.56 mm, which improved to 3.93 ± 0.52 mm with an average lagophthalmos of 0.91 ± 0.74 mm at the last follow-up. A total of 91.4% of eyelids had excellent eyelid contour, crease, and eyelash angle at the final follow-up. One eyelid required revision surgery. There were no other significant complications.
CONCLUSIONS
For poor function recurrent congenital ptosis, combining levator resection and frontalis muscle advancement is an effective method that results in long-term correction with cosmetically pleasing outcomes and minimal complications.
Topics: Humans; Blepharoplasty; Retrospective Studies; Oculomotor Muscles; Blepharoptosis; Eyelids; Treatment Outcome
PubMed: 35469061
DOI: 10.1038/s41433-022-02071-w -
American Journal of Ophthalmology Jul 2014To report the prevalence and causes of strabismus in children with eyelid ptosis diagnosed in a well-defined population over a 40-year period.
PURPOSE
To report the prevalence and causes of strabismus in children with eyelid ptosis diagnosed in a well-defined population over a 40-year period.
DESIGN
Retrospective, population-based cohort study.
METHODS
We retrospectively reviewed the charts of 107 patients (<19 years) for the prevalence and causes of strabismus in children who were diagnosed with childhood eyelid ptosis as residents of Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004.
RESULTS
Strabismus was diagnosed in 20 (18.7%) of the 107 patients with childhood ptosis. Of the 81 patients, 8 (9.9%) were diagnosed with simple congenital ptosis and had strabismus, of which there were 4 (4.9%) cases of exotropia and 4 (4.9%) cases of esotropia. There were no cases of isolated vertical deviation.
CONCLUSIONS
Strabismus occurred in 1 of 5 children diagnosed with any form of childhood ptosis in this population-based cohort. Strabismus affected approximately 1 of 10 patients diagnosed with simple congenital ptosis, and a predominance of isolated horizontal deviations was equally divided between esotropia and exotropia.
Topics: Blepharoptosis; Child; Child, Preschool; Cohort Studies; Female; Humans; Infant; Male; Minnesota; Prevalence; Retrospective Studies; Strabismus
PubMed: 24727259
DOI: 10.1016/j.ajo.2014.04.001 -
CMAJ : Canadian Medical Association... Oct 2015
Topics: Blepharoptosis; Canada; Humans; National Health Programs; Physical Examination
PubMed: 26009586
DOI: 10.1503/cmaj.140579