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The Journal of Thoracic and... Jun 2021
Topics: Child; Child, Preschool; Heart Defects, Congenital; Humans; Infant; Lung Transplantation; Pulmonary Veins; Stenosis, Pulmonary Vein
PubMed: 32763037
DOI: 10.1016/j.jtcvs.2020.05.117 -
JACC. Clinical Electrophysiology Jul 2019
Topics: Atrial Fibrillation; Catheter Ablation; Humans; Pulmonary Veins; Temperature; Time Factors
PubMed: 31320007
DOI: 10.1016/j.jacep.2019.05.007 -
Circulation Journal : Official Journal... Nov 2023
Topics: Humans; Stenosis, Pulmonary Vein; Pulmonary Veins; Catheter Ablation; Iatrogenic Disease; Atrial Fibrillation; Treatment Outcome; Angioplasty, Balloon
PubMed: 37380435
DOI: 10.1253/circj.CJ-23-0388 -
The Journal of Thoracic and... Feb 2018
Topics: Pulmonary Veins
PubMed: 29153435
DOI: 10.1016/j.jtcvs.2017.09.128 -
The Journal of Thoracic and... Feb 2022
Topics: Heterotaxy Syndrome; Humans; Pulmonary Veins; Scimitar Syndrome
PubMed: 34218928
DOI: 10.1016/j.jtcvs.2021.04.031 -
The Journal of Thoracic and... Feb 2022
Topics: Constriction, Pathologic; Humans; Pulmonary Veins; Recurrence
PubMed: 33933258
DOI: 10.1016/j.jtcvs.2021.03.094 -
Journal of General Internal Medicine Feb 2016
Topics: Adult; Dextrocardia; Female; Humans; Pulmonary Veins; Scimitar Syndrome; Tomography, X-Ray Computed
PubMed: 25941106
DOI: 10.1007/s11606-015-3358-7 -
The Journal of Thoracic and... Jun 2021
Topics: Humans; Pulmonary Veins; Pulmonary Veno-Occlusive Disease; Stenosis, Pulmonary Vein
PubMed: 32868046
DOI: 10.1016/j.jtcvs.2020.06.066 -
Europace : European Pacing,... Apr 2023Single-shot pulmonary vein isolation can improve procedural efficiency. To assess the capability of a novel, expandable lattice-shaped catheter to rapidly isolate...
AIMS
Single-shot pulmonary vein isolation can improve procedural efficiency. To assess the capability of a novel, expandable lattice-shaped catheter to rapidly isolate thoracic veins using pulsed field ablation (PFA) in healthy swine.
METHODS AND RESULTS
The study catheter (SpherePVI; Affera Inc) was used to isolate thoracic veins in two cohorts of swine survived for 1 and 5 weeks. In Experiment 1, an initial dose (PULSE2) was used to isolate the superior vena cava (SVC) and the right superior pulmonary vein (RSPV) in six swine and the SVC only in two swine. In Experiment 2, a final dose (PULSE3) was used for SVC, RSPV, and left superior pulmonary vein (LSPV) in five swine. Baseline and follow-up maps, ostial diameters, and phrenic nerve were assessed. Pulsed field ablation was delivered atop the oesophagus in three swine. All tissues were submitted for pathology. In Experiment 1, all 14/14 veins were isolated acutely with durable isolation demonstrated in 6/6 RSPVs and 6/8 SVC. Both reconnections occurred when only one application/vein was used. Fifty-two and 32 sections from the RSPVs and SVC revealed transmural lesions in 100% with a mean depth of 4.0 ± 2.0 mm. In Experiment 2, 15/15 veins were isolated acutely with 14/15 veins (5/5 SVC, 5/5 RSPV, and 4/5 LSPV) durably isolated. Right superior pulmonary vein (31) and SVC (34) sections had 100% transmural, circumferential ablation with minimal inflammation. Viable vessels and nerves were noted without evidence of venous stenosis, phrenic palsy, or oesophageal injury.
CONCLUSION
This novel expandable lattice PFA catheter can achieve durable isolation with transmurality and safety.
Topics: Swine; Animals; Atrial Fibrillation; Pulmonary Veins; Vena Cava, Superior; Feasibility Studies; Catheter Ablation; Catheters; Treatment Outcome
PubMed: 36794699
DOI: 10.1093/europace/euad030 -
Biological & Pharmaceutical Bulletin 2013The pulmonary vein contains a myocardial layer extending from the left atrium, which is receiving attention as the source of ectopic electrical activity underlying... (Review)
Review
The pulmonary vein contains a myocardial layer extending from the left atrium, which is receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Electrophysiological and pharmacological analysis of the pulmonary vein myocardium performed in various experimental animal species have revealed characteristics such as presence of intracellular Ca(2+) oscillations and low repolarizing potency. The automaticity of the pulmonary vein myocardium is affected by various neurotransmitters, hormones and pharmacological agents. Clarification of the mechanisms and regulation of pulmonary vein automaticity would lead to the development of novel therapeutic strategies and pharmacological agents for atrial fibrillation.
Topics: Action Potentials; Animals; Calcium; Myocardium; Pulmonary Veins
PubMed: 23302630
DOI: 10.1248/bpb.b212020