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Ugeskrift For Laeger Nov 2020In this review, we discuss Malassezia folliculitis (MF), which is an inflammation in the hair follicles caused by different Malassezia species. The prevalence of MF in... (Review)
Review
In this review, we discuss Malassezia folliculitis (MF), which is an inflammation in the hair follicles caused by different Malassezia species. The prevalence of MF in the population worldwide ranges from 1% to 17%. Clinically, it may be difficult to distinguish from acne vulgaris, as it presents as erythematous 2-4 mm large papules and pustules on the back, chest and neck. Adequate diagnostic methods, including microscopy or biopsy, are essential to confirm the MF diagnosis, and to ensure initiation of the appropriate anti-fungal treatment.
Topics: Acne Vulgaris; Biopsy; Dermatomycoses; Folliculitis; Humans; Malassezia
PubMed: 33215579
DOI: No ID Found -
Genes Jun 2023Psoriasis is a chronic inflammatory skin disease characterized by the appearance of clearly demarcated erythematous and scaly plaques. It can be divided into various... (Review)
Review
Psoriasis is a chronic inflammatory skin disease characterized by the appearance of clearly demarcated erythematous and scaly plaques. It can be divided into various types, including plaque, nail, guttate, inverse, and pustular psoriasis. Plaque psoriasis is the most commonly occurring type, though there is another rare but severe pustular autoinflammatory skin disease called generalized pustular psoriasis (GPP), which manifests with acute episodes of pustulation and systemic symptoms. Though the etiopathogenesis of psoriasis is not yet fully understood, a growing body of literature has demonstrated that both genetic and environmental factors play a role. The discovery of genetic mutations associated with GPP has shed light on our comprehension of the mechanisms of the disease, promoting the development of targeted therapies. This review will summarize genetic determinants as known and provide an update on the current and potential treatments for GPP. The pathogenesis and clinical presentation of the disease are also included for a comprehensive discussion.
Topics: Humans; Interleukins; Psoriasis; Skin; Mutation; Skin Diseases, Vesiculobullous
PubMed: 37372477
DOI: 10.3390/genes14061297 -
Canadian Family Physician Medecin de... Mar 1982A 37-year-old woman experienced local symptoms on returning from a camping trip. Within three weeks she developed generalized symptoms and was hospitalized. Tularemia,...
A 37-year-old woman experienced local symptoms on returning from a camping trip. Within three weeks she developed generalized symptoms and was hospitalized. Tularemia, and often overlooked cause of bubo formation, is endemic in Nevada. The diagnosis should be considered when patients who have visited such an area present with enlarged, painful lymph nodes, skin pustules, ulcers, headache, myalgia, malaise and nausea. Cultures tend to be negative, because the causative organism, Francisella tularensis, needs cysteine. While there are five clinical forms of tularemia, man tends to get the ulceroglandular form, mostly from insect bites. Treatment consists of intramuscular streptomycin 0.5 g every 12 hours until the temperature is normal.
PubMed: 21286087
DOI: No ID Found -
Dermatology Practical & Conceptual Jan 2021mites are highly found in the skin of patients with rosacea. The diagnosis of can be made by standardized skin surface biopsy. Dermoscopy is a tool used in the...
BACKGROUND
mites are highly found in the skin of patients with rosacea. The diagnosis of can be made by standardized skin surface biopsy. Dermoscopy is a tool used in the noninvasive diagnosis of various dermatological diseases.
OBJECTIVES
To determine whether dermoscopic features of demodicosis are associated with the result of standardized skin surface biopsy in patients with rosacea and to compare dermoscopic features of rosacea in -positive and negative samples and type.
METHODS
A total of 30 patients (7 male, 23 female) were included in the study. Dermoscopic examination was performed on both the clinically most severely affected areas and adjacent healthy skin. The skin surface biopsy sample was taken from the same place from where the dermoscopic image was taken.
RESULTS
A total of 83 (lesion n = 60, non-lesion n = 23) areas were evaluated. was detected in 60.2% (n = 50) of the samples. Half of these samples revealed only , and the remaining half revealed and Of the -positive samples, 88% had tails (P =0.001) and 68% follicular openings (P = 0.002) on dermoscopy. In +-positive samples, the rate of scale and pustule was higher than positive samples (P = 0.017 and P = 0032, respectively).
CONCLUSIONS
The sensitivity and specificity of tail are higher than follicular opening and scale and pustule detection with dermoscopy and may indicate the coexistence of both and
PubMed: 33614217
DOI: 10.5826/dpc.1101a139 -
Dermatology and Therapy Dec 2023Rosacea is a chronic inflammatory disease with a multifactorial pathogenesis. The wide spectrum of clinical phenotypes, including erythema, telangiectasia, inflammatory... (Review)
Review
Rosacea is a chronic inflammatory disease with a multifactorial pathogenesis. The wide spectrum of clinical phenotypes, including erythema, telangiectasia, inflammatory papules and pustules, and phyma, demand an individualized approach to treatment. This narrative review offers an updated reference for rosacea management by covering the latest developments in both topical and systemic treatments, including data from newly approved therapies, updates to current treatment modalities and ongoing clinical trials. Although use of benzoyl peroxide as a treatment for rosacea has typically been limited due to irritation, the improved tolerability due to microencapsulation of benzoyl peroxide 5% cream provides a new therapeutic option for patients with rosacea. Minocycline foam and topical ivermectin cream add to our armamentarium of treatment options, particularly for inflammatory papules and pustules. Sarecycline has a narrower spectrum of antibacterial activity, which might reduce the development of antibiotic resistance and disruption of the microbiome compared to other oral antibiotics. Brimonidine gel and oxymetazoline cream provide topical options for redness and flushing. There is emerging evidence about the role of hydroxychloroquine and intradermal botulinum toxin A, which may improve rosacea through their effects on mast cells. The clinical trials pipeline includes agents with a variety of mechanisms, including mast cell stabilization, antimicrobial, anti-inflammatory, and vasoconstrictive effects. However, the clinical pipeline for rosacea appears limited, and there remain important unmet needs for patients with more recalcitrant rosacea or phymatous disease. In addition, there is a need for comparative effectiveness studies to identify the highest value treatment approaches for patients with rosacea.
PubMed: 37824060
DOI: 10.1007/s13555-023-01048-1 -
Obstetric Medicine Mar 2023Impetigo herpetiformis (IH) is a pregnancy-specific dermatosis that is currently considered a form of generalised pustular psoriasis and mainly occurs in late pregnancy... (Review)
Review
Impetigo herpetiformis (IH) is a pregnancy-specific dermatosis that is currently considered a form of generalised pustular psoriasis and mainly occurs in late pregnancy during the third trimester. IH presents as erythematous patches and pustules and might have systemic involvement. The disease may be associated with severe maternal, fetal, and neonatal complications. IH treatment is very challenging, however, various therapeutic options are available and effective for disease treatment.
PubMed: 37139500
DOI: 10.1177/1753495X221074610 -
Actas Dermo-sifiliograficas May 2008Rosacea is a chronic inflammatory skin disease appearing in the central area of the face of middle-aged patients. It is characterized by flushing, permanent erythema,... (Review)
Review
Rosacea is a chronic inflammatory skin disease appearing in the central area of the face of middle-aged patients. It is characterized by flushing, permanent erythema, telangiectasia, papules, pustules, and the absence of comedones. Its underlying pathophysiological mechanisms are not completely understood, although a number of hypotheses point to vascular abnormalities and infection by microorganisms such as Demodex folliculorum. Rosacea is classified into 4 subtypes, which determine the therapeutic approach based on skin care, topical antiinflammatory agents, topical and oral antibiotics and retinoids, and, in some instances, light-based therapy and surgery.
Topics: Diagnosis, Differential; Humans; Rosacea
PubMed: 18394399
DOI: No ID Found