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Polskie Archiwum Medycyny Wewnetrznej Sep 2016
Topics: Adenine; Cyclosporine; Drug Therapy, Combination; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Piperidines; Prednisone; Pyoderma Gangrenosum; Pyrazoles; Pyrimidines
PubMed: 27698335
DOI: 10.20452/pamw.3578 -
The Canadian Veterinary Journal = La... Feb 2016
Topics: Animals; Anti-Bacterial Agents; Dog Diseases; Dogs; Pyoderma; Staphylococcal Skin Infections; Staphylococcus
PubMed: 26834275
DOI: No ID Found -
Open Veterinary Journal 2021Dermatological infections are the most common cases in the daily pet clinic. Since its discovery in 1990, subspecies have been reported more frequently in canine...
BACKGROUND
Dermatological infections are the most common cases in the daily pet clinic. Since its discovery in 1990, subspecies have been reported more frequently in canine otitis externa and pyoderma and even in cases of zoonoses.
AIM
Detect the presence of subsp. of canine otitis externa and pyoderma, its antimicrobial resistance, and the presence of Agen.
METHODS
Three-hundred-thirty-one swabs from dogs with otitis externa and pyoderma were cultured on bacteriological agar for bacterial isolation and subsequent biochemical and molecular identification. The identified subsp. were evaluated for their antimicrobial susceptibility using the Kirby-Bauer technique, including an oxacillin disk, and subsequently, a PCR was run to identify which ones had the A gene.
RESULTS
Thirty-four (22.97%) and twelve (6.56%) isolates were identified as subspecies from otitis externa and pyoderma, respectively. Fluoroquinolones, the most widely used group of antibiotics in Peru, showed a susceptibility of 58.82% (20/34) in cases of otitis externa and 50% (6/12) in cases of canine pyoderma. Meanwhile, nitrofurantoin was the antibiotic with the best efficacy in both cases, with 97% (33/34) in otitis externa and 83% (10/12) in pyoderma. Furthermore, 40% (13/34) of subsp. isolated from otitis externa were resistant to methicillin, and 85.29% (29/34) had the A gene. On the other hand, the only methicillin-resistant isolate from pyoderma was also the only one with a A gene.
CONCLUSION
This study is the first report of subsp. in Peru, finding a higher percentage than reported in other South American countries.
Topics: Animals; Dog Diseases; Dogs; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Otitis Externa; Pyoderma; Staphylococcus
PubMed: 34722197
DOI: 10.5455/OVJ.2021.v11.i3.5 -
Frontiers in Immunology 2021This study aims to describe the characteristics of patients diagnosed with pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome at a single center in China...
OBJECTIVES
This study aims to describe the characteristics of patients diagnosed with pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome at a single center in China and provide an up-to-date literature review.
METHODS
The clinical data and genotype of three Chinese Han patients were carefully documented and studied. We also conducted a systematic literature review on PAPA syndrome.
RESULTS
A total of three patients were diagnosed with PAPA syndrome at our center from 2018 to 2020. Arthritis was observed in all three patients, while pyoderma gangrenosum (PG) was found in two patients and acne in one patient. Other manifestations included pathergy reaction, intermittent fever, oral ulcer, keratitis, proteinuria, and hematuria. The A230T mutation was identified in two patients, and a novel Y119C variation was revealed in a sporadic patient. A total of 76 patients with PAPA syndrome reported in 29 articles were included in our literature review. The classical triad of arthritis, PG, and acne was visible in only 16 (25.4%) patients, while 24 (38.1%) exhibited only one major symptom. Skin lesions were more commonly seen in patients with adult-onset disease than those with childhood-onset disease (100 . 83%), whereas arthritis was less common (50 . 98.1%). Steroid and/or biological agents were effective in most patients.
CONCLUSIONS
The rarity and phenotypic heterogeneity associated with PAPA syndrome make the diagnosis a huge challenge to physicians, especially in adult patients. A significant portion of patients did not exhibit the full spectrum of the classical triad. Accordingly, gene testing is critically helpful for diagnosis.
Topics: Acne Vulgaris; Adaptor Proteins, Signal Transducing; Adult; Arthritis, Infectious; Biological Products; Cytoskeletal Proteins; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Mutation; Phenotype; Predictive Value of Tests; Pyoderma Gangrenosum; Steroids; Treatment Outcome
PubMed: 34745107
DOI: 10.3389/fimmu.2021.735851 -
The Medical Journal of Malaysia Aug 2007Pyoderma Gangrenosum (PG) is a non-infective, necrotising neutrophilic dermatosis. Many diseases may mimic PG. It may be idiopathic or may be associated with a systemic...
Pyoderma Gangrenosum (PG) is a non-infective, necrotising neutrophilic dermatosis. Many diseases may mimic PG. It may be idiopathic or may be associated with a systemic disorder. We report a case of PG in association with ulcerative colitis.
Topics: Aged; Colitis, Ulcerative; Humans; Malaysia; Male; Outcome Assessment, Health Care; Pyoderma Gangrenosum
PubMed: 18246920
DOI: No ID Found -
Proceedings of the Royal Society of... Apr 1960
Topics: Humans; Medical Records; Pyoderma; Pyoderma Gangrenosum
PubMed: 14424997
DOI: No ID Found -
Medicina 2022
Topics: Humans; Pyoderma Gangrenosum
PubMed: 35037878
DOI: No ID Found -
Anais Brasileiros de Dermatologia 2022
Topics: Acne Vulgaris; Angiomatosis; Humans; Hyperplasia; Pyoderma Gangrenosum
PubMed: 34782194
DOI: 10.1016/j.abd.2020.08.034 -
BMC Veterinary Research Nov 2022Streptococcus canis causes deep pyoderma in canines, which raises concerns about the risk of isolates from lesions acquiring an antibiotic-resistant phenotype. It is...
BACKGROUND
Streptococcus canis causes deep pyoderma in canines, which raises concerns about the risk of isolates from lesions acquiring an antibiotic-resistant phenotype. It is necessary to identify effective antibiotics and the characteristics of the pathogenic cluster for S. canis-associated deep pyoderma.
RESULTS
The signalment, molecular typing, and antibiotic-resistant status of S. canis isolated from deep pyoderma lesions (27 strains) and oral cavities (26 strains) were analyzed. Older dogs tended to have S. canis-associated deep pyoderma (15 of 27 dogs over 10 years old). Veterinarians chose quinolones for 10/16 cases (63%), even though the rate of quinolone-resistant strains of S. canis is 38-59%. Although 70% of the strains showed resistance to three or more antibiotic classes (37/53), 94% (50/53) strains showed sensitivity for penicillins. We also identified β-lactamase activity among penicillin-resistant strains of S. canis. Clonal complex 13 (CC13) was detected only in lesions and formed independent clusters in the phylogenetic tree. One strain of CC13 was resistant to the anti-methicillin-resistant Staphylococcus aureus drugs, vancomycin and linezolid.
CONCLUSION
Although antibiotic-resistant strains of S. canis are isolated at a high rate, they can currently be treated with β-lactamase-inhibiting penicillins. CC13 may be a pathogenic cluster with high levels of antibiotics resistance.
Topics: Dogs; Animals; Pyoderma; Anti-Bacterial Agents; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Phylogeny; Dog Diseases; Penicillins; beta-Lactamases; Staphylococcal Infections
PubMed: 36352470
DOI: 10.1186/s12917-022-03482-3 -
Acta Dermato-venereologica May 2015Pyoderma gangrenosum (PG) is an inflammatory disease characterized by painful skin ulcerations with undermined and erythematous borders. The etiology of PG is not well... (Comparative Study)
Comparative Study Review
Pyoderma gangrenosum (PG) is an inflammatory disease characterized by painful skin ulcerations with undermined and erythematous borders. The etiology of PG is not well understood, but it is generally considered to be an aberrant immune response characterized by a dermal neutrophilc infiltrate. Given the existence of only a few PG clinical trials, treatment options are largely based upon anecdotal data and small case studies. In addition to classic immunosuppressive medications, PG has been reported to respond well to the anti-TNF agents, infliximab, etanercept, adalimumab. Newer biologics such as ustekinumab (anti-IL-23), ixekizumab (anti-IL-17) and brodalumab (anti-IL-17R) are promising given the effect of IL-17 on neutrophil migration. However, the effectiveness of these newer agents remains to be rigorously evaluated. Multi-drug regimens have not been well described in the literature but are an excellent alternative for patients with refractory disease. Herein, we provide a comprehensive review of the pathophysiology of PG and of the different treatments available for managing PG patients, including the theoretical benefit of initiating multidrug regimens. We also provide one possible treatment algorithm for patients with refractory disease and give examples of refractory PG cases successfully treated with multidrug regimens.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Biological Products; Combined Modality Therapy; Debridement; Drug Therapy, Combination; Female; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Prognosis; Pyoderma Gangrenosum; Recurrence; Risk Assessment; Severity of Illness Index; Treatment Outcome; Wound Healing; Young Adult
PubMed: 25387526
DOI: 10.2340/00015555-2008