Authors: John Nyberg, Even Olav Jakobsen, Andreas Østvik...

BACKGROUND

Myocardial deformation by echocardiographic strain imaging is a key measurement in cardiology, providing valuable diagnostic and prognostic information. Reference ranges for strain should be established from large healthy populations with minimal methodologic biases and variability.

OBJECTIVES

The aim of this study was to establish echocardiographic reference ranges, including lower normal limits of global strains for all 4 cardiac chambers, by guideline-directed dedicated views from a large healthy population and to evaluate the influence of subject-specific characteristics on strain.

METHODS

In total, 1,329 healthy participants from HUNT4Echo, the echocardiographic substudy of the 4th wave of the Trøndelag Health Study, were included. Echocardiographic recordings specific for each chamber were optimized according to current recommendations. Two experienced sonographers recorded all echocardiograms using GE HealthCare Vivid E95 scanners. Analyses were performed by experts using GE HealthCare EchoPAC.

RESULTS

The reference ranges for left ventricular (LV) global longitudinal strain and right ventricular free-wall strain were -24% to -16% and -35% to -17%, respectively. Correspondingly, left atrial (LA) and right atrial (RA) reservoir strains were 17% to 49% and 17% to 59%. All strains showed lower absolute values with higher age, except for LA and RA contractile strains, which were higher. The feasibility for strain was overall good (LV 96%, right ventricular 83%, LA 94%, and RA 87%). All chamber-specific strains were associated with age, and LV strain was associated with sex.

CONCLUSIONS

Reference ranges of strain for all cardiac chambers were established based on guideline-directed chamber-specific recordings. Age and sex were the most important factors influencing reference ranges and should be considered when using strain echocardiography.

Topics: Humans; Reference Values; Global Longitudinal Strain; Predictive Value of Tests; Echocardiography; Heart Atria; Ventricular Function, Left

PubMed: 37921718
DOI: 10.1016/j.jcmg.2023.08.011

Authors: Maria Rosa Costanzo, Thomas H Marwick

Topics: Humans; Hypertension, Pulmonary; Heart Atria; Heart Ventricles

PubMed: 37587583
DOI: 10.1016/j.jacc.2023.06.009

Authors: Pauli Pöyhönen, Jouni Kuusisto, Jani Pirinen...

BACKGROUND

Recent studies suggest left atrial (LA) dysfunction in cryptogenic stroke. We studied the dynamics of right atrium (RA) and right atrial appendage (RAA) in young adults with cryptogenic stroke. We hypothesised that bi-atrial dysfunction and blood stagnation might contribute to thrombosis formation in patients with patent foramen ovale (PFO), as deep venous thrombosis is detected only in the minority of patients.

METHODS

Thirty patients (aged 18-49) with a first-ever cryptogenic stroke and 30 age-matched and sex-matched stroke-free controls underwent cardiac magnetic resonance (CMR) imaging. An approach to estimate the RAA volume was developed, using crista terminalis and pectinate muscles as anatomical landmarks. Atrial expansion indices were calculated as (maximal volume - minimal volume) ×100%/minimal volume. Total pulmonary to systemic blood flow ratio (Qp/Qs) was based on phase contrast CMR. Right-to-left shunt (RLS) was evaluated with transoesophageal echocardiography in 29 patients and transcranial Doppler in 30 controls, moderate-to-severe RLS considered as clinically significant.

RESULTS

We found that RA and RAA volumes were similar between patients and controls. Also, RA expansion index was similar, but RAA (95.6%±21.6% vs 108.7%±25.8%, p=0.026) and LA (126.2%±28% vs 144.9%±36.3%, p=0.023) expansion indices were lower in patients compared with controls. Seven (24%) of 29 patients had an RLS compared with 1 (3%) of 30 controls (p=0.012). Among 59 study subjects, RLS was associated with lower RA (81.9%±15.9% vs 98.5%±29.5%, p=0.030), RAA (84.7%±18% vs 105.6%±24.1%, p=0.022), LA (109.8%±18.6% vs 140.1%±33.7%, p=0.017) and LAA (median 102.9% (IQR 65.6%-121.7%) vs 229.1% (151.8%-337.5%], p=0.002) expansion indices and lower Qp/Qs ratio (0.91±0.06 vs 0.98±0.07, p=0.027).

CONCLUSIONS

This study suggests bi-atrial dysfunction in young adults with cryptogenic stroke, associated with moderate-to-severe RLS. Dysfunction of the atria and atrial appendages may be an additional mechanism for PFO-related stroke.

TRIAL REGISTRATION NUMBER

NCT01934725.

Topics: Adolescent; Adult; Atrial Appendage; Atrial Function, Right; Case-Control Studies; Echocardiography, Transesophageal; Female; Heart Atria; Humans; Ischemic Stroke; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Ultrasonography, Doppler, Transcranial; Ventricular Dysfunction, Right; Young Adult

PubMed: 34006504
DOI: 10.1136/openhrt-2021-001596

Authors: Barry A Borlaug, Masaru Obokata

Topics: Atrial Fibrillation; Atrial Function, Right; Heart Atria; Heart Failure; Humans; Stroke Volume

PubMed: 30343068
DOI: 10.1016/j.jcmg.2018.08.019

Authors: Ljiljana Rankovic-Nicic, Milica Dragicevic-Antonic, Goran Loncar...

Idiopathic dilatation of the right atrium is a rare condition with an unknown etiology. It is characterized by a significant enlargement of the right atrium without the presence of other valvopathies, intracardiac shunts, or pulmonary hypertension. This report presents the case of a 50-year-old woman with a significantly enlarged right atrium that was identified at birth; however, a definitive diagnosis was made later in life. The patient did not have any genetic diseases. Through the help of regular follow-up, anticoagulant therapy, previous radio-frequency ablation, and antiarrhythmic medications, she was able to carry a pregnancy to full term and live a regular life.

Topics: Female; Humans; Middle Aged; Anti-Arrhythmia Agents; Dilatation, Pathologic; Heart Atria

PubMed: 38111176
DOI: 10.14503/THIJ-23-8192

Review

Authors: Andrés González-Ortiz, Moisés Mier-Martínez, Alfonso J Martínez-García...

Idiopathic dilatation of the right atrium is a rare malformation characterized by disproportionate growth of the right atrium in the absence of a cause that justifies it. We present the case of a patient with idiopathic dilatation of the right atrium diagnosed since fetal life.

Topics: Humans; Dilatation; Heart Atria; Dilatation, Pathologic

PubMed: 37553112
DOI: 10.24875/ACM.22000026

Authors: Fang-Fang Li, Yi-Jiang Zhou, Hui Yan...

Topics: Heart Atria; Humans; Rupture, Spontaneous; Thrombosis

PubMed: 29336375
DOI: 10.4103/0366-6999.222329

Authors: John Gorcsan, Yoshiyuki Orihara

Topics: Humans; Atrial Fibrillation; Clinical Relevance; Predictive Value of Tests; Heart Atria; Echocardiography

PubMed: 36889848
DOI: 10.1016/j.jcmg.2023.01.010

Authors: Edward Pietrzyk, Olga Jelonek, Iwona Gorczyca...

<b>Introduction:</b> Tumors which most frequently metastasize to the heart include: malignant melanoma, lung cancer, breast cancer, ovarian cancer, kidney cancer, leukemia, lymphomas and esophageal cancer. <br><b>Purpose:</b> The purpose of this paper was clinical analysis of a group of patients operated in deep hypothermic circulatory arrest due to tumors of the right atrium and the inferior vena cava. <br><b>Material and method:</b> The study covered 7 patients operated at the Cardiac Surgery Clinic with a cardiac tumor diagnosed on the basis of an echocardiographic assessment in the years 2012-2019. Before qualifying for surgical treatment, each patient underwent: thorough interview and physical examination, 12-lead ECG, laboratory tests and echocardiography. Patients additionally underwent: computed tomography of the chest or abdomen, magnetic resonance imaging and coronary angiography on the basis of which patients with significant coronary artery changes underwent simultaneous coronary artery bypass graft. After preparation, the tumor was excised from the vena cava and right atrium with simultaneous removal of the primary tumor, most often kidney cancer. Early and distant results of treatment were analyzed in the examined group of patients to determine the following endpoints: hospital mortality and survival after surgery: after 3 months and 12 months. <br><b>Results:</b> Of all operated patients: 2 individuals died in the early postoperative period due to hemorrhagic complications (hospital mortality - 28.6%), and 5 patients (71.4%) were discharged from the Clinic in a good general condition. In total, 3-month survival was 71.4%, and 12-month survival amounted to 28.6%. <br><b>Conclusions:</b> Surgeries are very complex and challenging, and usually take on average 8-10 hours. It can improve the outcomes of palliative oncological treatment, better physical function (cardiovascular fitness) and extend life from several months to several years in more than ²/3 patients.

Topics: Circulatory Arrest, Deep Hypothermia Induced; Coronary Artery Bypass; Heart Atria; Humans; Kidney Neoplasms; Vena Cava, Inferior

PubMed: 32908013
DOI: 10.5604/01.3001.0014.1371

Authors: Jeroen N Wessels, Jessie van Wezenbeek, Jari de Rover...

BACKGROUND

Precapillary pulmonary hypertension (precPH) patients have altered right atrial (RA) function and right ventricular (RV) diastolic stiffness.

OBJECTIVES

This study aimed to investigate RA function using pressure-volume (PV) loops, isolated cardiomyocyte, and histological analyses.

METHODS

RA PV loops were constructed in control subjects (n = 9) and precPH patients (n = 27) using magnetic resonance and catheterization data. RA stiffness (pressure rise during atrial filling) and right atrioventricular coupling index (RA minimal volume / RV end-diastolic volume) were compared in a larger cohort of patients with moderate (n = 39) or severe (n = 41) RV diastolic stiffness. Cardiomyocytes were isolated from RA tissue collected from control subjects (n = 6) and precPH patients (n = 9) undergoing surgery. Autopsy material was collected from control subjects (n = 6) and precPH patients (n = 4) to study RA hypertrophy, capillarization, and fibrosis.

RESULTS

RA PV loops showed 3 RA cardiac phases (reservoir, passive emptying, and contraction) with dilatation and elevated pressure in precPH. PrecPH patients with severe RV diastolic stiffness had increased RA stiffness and worse right atrioventricular coupling index. Cardiomyocyte cross-sectional area was increased 2- to 3-fold in precPH, but active tension generated by the sarcomeres was unaltered. There was no increase in passive tension of the cardiomyocytes, but end-stage precPH showed reduced number of capillaries per mm accompanied by interstitial and perivascular fibrosis.

CONCLUSIONS

RA PV loops show increased RA stiffness and suggest atrioventricular uncoupling in patients with severe RV diastolic stiffness. Isolated RA cardiomyocytes of precPH patients are hypertrophied, without intrinsic sarcomeric changes. In end-stage precPH, reduced capillary density is accompanied by interstitial and perivascular fibrosis.

Topics: Humans; Myocytes, Cardiac; Hypertension, Pulmonary; Atrial Fibrillation; Heart Atria; Atrial Appendage

PubMed: 37587582
DOI: 10.1016/j.jacc.2023.05.063