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Acta Veterinaria Scandinavica 1983Fenchlorphos was administered orally in doses of 0, 12.5, 25 and 50 mg per kg to pregnant rabbits from day 6 to 18 of gestation. No effect on implantation efficacy,...
Fenchlorphos was administered orally in doses of 0, 12.5, 25 and 50 mg per kg to pregnant rabbits from day 6 to 18 of gestation. No effect on implantation efficacy, number of live fetuses, or fetal weight was observed. The incidence of major malformations such as cardiovascular and brain anomalies was, however, increased in the medicated groups. Major skeletal malformations were more frequent in the medicated groups; minor skeletal variation were about equal in all groups. Dose-relationship was observed for cardiovascular malformations and cerebellar hypoplasia.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Brain; Dose-Response Relationship, Drug; Female; Heart Defects, Congenital; Organothiophosphorus Compounds; Pregnancy; Rabbits
PubMed: 6197870
DOI: 10.1186/BF03546733