-
Molecular Oncology Mar 2021An estimated 30-40% of cancers can be prevented through changes in modifiable lifestyle and environmental risk factors known to be associated with cancer incidence.... (Review)
Review
An estimated 30-40% of cancers can be prevented through changes in modifiable lifestyle and environmental risk factors known to be associated with cancer incidence. Despite this knowledge, there remains limited awareness that these associations exist. The purpose of this review article was to summarize the epidemiologic evidence concerning the contribution of physical activity, sedentary behavior, and obesity to cancer etiology and to provide an overview of the biologic mechanisms that may be operative between these factors and cancer incidence. Strong and consistent evidence exists that higher levels of physical activity reduce the risk of six different cancer sites (bladder, breast, colon, endometrial, esophageal adenocarcinoma, gastric cardia), whereas moderate evidence inversely associates physical activity with lung, ovarian, pancreatic and renal cancer, and limited evidence inversely correlates physical activity with prostate cancer. Sedentary behavior, independent of physical activity, has been shown to increase the risk of colon, endometrial, and lung cancers. Obesity is an established risk factor for 13 different cancer sites (endometrial, postmenopausal breast, colorectal, esophageal, renal/kidneys, meningioma, pancreatic, gastric cardia, liver, multiple myeloma, ovarian, gallbladder, and thyroid). The main biologic mechanisms whereby physical activity, sedentary behavior, and obesity are related to cancer incidence include an effect on endogenous sex steroids and metabolic hormones, insulin sensitivity, and chronic inflammation. Several emerging pathways related to oxidative stress, DNA methylation, telomere length, immune function, and gut microbiome are presented. Key recommendations for future research in both the epidemiology and biology of the associations between physical activity, sedentary behavior, obesity, and cancer risk are also provided.
Topics: Animals; Exercise; Humans; Incidence; Neoplasms; Obesity; Protective Factors; Risk Factors; Sedentary Behavior
PubMed: 32741068
DOI: 10.1002/1878-0261.12772 -
The Journal of Nutrition, Health & Aging 2021The human ageing process is universal, ubiquitous and inevitable. Every physiological function is being continuously diminished. There is a range between two distinct...
The human ageing process is universal, ubiquitous and inevitable. Every physiological function is being continuously diminished. There is a range between two distinct phenotypes of ageing, shaped by patterns of living - experiences and behaviours, and in particular by the presence or absence of physical activity (PA) and structured exercise (i.e., a sedentary lifestyle). Ageing and a sedentary lifestyle are associated with declines in muscle function and cardiorespiratory fitness, resulting in an impaired capacity to perform daily activities and maintain independent functioning. However, in the presence of adequate exercise/PA these changes in muscular and aerobic capacity with age are substantially attenuated. Additionally, both structured exercise and overall PA play important roles as preventive strategies for many chronic diseases, including cardiovascular disease, stroke, diabetes, osteoporosis, and obesity; improvement of mobility, mental health, and quality of life; and reduction in mortality, among other benefits. Notably, exercise intervention programmes improve the hallmarks of frailty (low body mass, strength, mobility, PA level, energy) and cognition, thus optimising functional capacity during ageing. In these pathological conditions exercise is used as a therapeutic agent and follows the precepts of identifying the cause of a disease and then using an agent in an evidence-based dose to eliminate or moderate the disease. Prescription of PA/structured exercise should therefore be based on the intended outcome (e.g., primary prevention, improvement in fitness or functional status or disease treatment), and individualised, adjusted and controlled like any other medical treatment. In addition, in line with other therapeutic agents, exercise shows a dose-response effect and can be individualised using different modalities, volumes and/or intensities as appropriate to the health state or medical condition. Importantly, exercise therapy is often directed at several physiological systems simultaneously, rather than targeted to a single outcome as is generally the case with pharmacological approaches to disease management. There are diseases for which exercise is an alternative to pharmacological treatment (such as depression), thus contributing to the goal of deprescribing of potentially inappropriate medications (PIMS). There are other conditions where no effective drug therapy is currently available (such as sarcopenia or dementia), where it may serve a primary role in prevention and treatment. Therefore, this consensus statement provides an evidence-based rationale for using exercise and PA for health promotion and disease prevention and treatment in older adults. Exercise prescription is discussed in terms of the specific modalities and doses that have been studied in randomised controlled trials for their effectiveness in attenuating physiological changes of ageing, disease prevention, and/or improvement of older adults with chronic disease and disability. Recommendations are proposed to bridge gaps in the current literature and to optimise the use of exercise/PA both as a preventative medicine and as a therapeutic agent.
Topics: Aged; Aging; Exercise; Exercise Therapy; Frailty; Health Promotion; Humans; Phenotype; Quality of Life; Sedentary Behavior
PubMed: 34409961
DOI: 10.1007/s12603-021-1665-8 -
Jornal de Pediatria 2022To describe the participation of the environment in the childhood obesity epidemic, since childhood obesity currently represents a great challenge, with high prevalence... (Review)
Review
OBJECTIVE
To describe the participation of the environment in the childhood obesity epidemic, since childhood obesity currently represents a great challenge, with high prevalence worldwide, including in Brazil.
DATA SOURCE
Survey of articles published in the last 10 years in PubMed, evaluating the interface between the environment and childhood obesity.
DATA SYNTHESIS
Recent studies show that the environment is very important in the etiopathogenesis of obesity and its comorbidities. Therefore, factors such as air pollution, exposure to chemical substances that interfere with the metabolism, excessive consumption of ultra-processed foods, changes in the intestinal microbiota, and sedentary lifestyle are associated with increased obesity, insulin resistance, type 2 diabetes, and changes in lipid metabolism. These factors have a greater impact on some stages of life, such as the first thousand days, as they affect the expression of genes that control the adipogenesis, energy expenditure, and the mechanisms for hunger/satiety control.
CONCLUSIONS
Environmental aspects must be taken into account in the prevention and treatment of childhood obesity, both from the individual and the population point of view, with adequate and comprehensive public health policies.
Topics: Child; Diabetes Mellitus, Type 2; Energy Metabolism; Fast Foods; Humans; Pediatric Obesity; Sedentary Behavior
PubMed: 34780713
DOI: 10.1016/j.jped.2021.10.002 -
Physical Activity Habits and Determinants, Sedentary Behaviour and Lifestyle in University Students.International Journal of Environmental... May 2020University students, as a result of their lifestyles, represent a section of the population that is most likely to adopt sedentary behaviours. The aim of the present...
University students, as a result of their lifestyles, represent a section of the population that is most likely to adopt sedentary behaviours. The aim of the present study was to analyse the determining factors dictating the performance of physical activity as well as sedentary behaviour among university students. A total of 608 students (64.6% women) from the University of Santiago de Compostela (Spain) were selected by stratified random sampling to take part in the study, which involved completing a questionnaire on lifestyle and physical activity. Of the participating students, 69.6% indicated that they performed physical activity; the main reasons given were to maintain fitness and for health, while a lack of time and laziness were the principal reasons given for abandoning or not taking up physical exercise. Significant associations were established between not doing physical activity and the time exposed to screens, time studying, feeling low and smoking; on the other hand, associations could be seen between doing physical activity and the participation of relatives (parents, mothers, partners, older siblings and friends) in physical activity, as well as a positive sense of satisfaction relating to physical education taught in schools. In conclusion, most of the university students did some physical activity, which was associated with less sedentary behaviour, while the influence of school physical education and of the habits of relatives played an important role.
Topics: Cross-Sectional Studies; Exercise; Female; Habits; Humans; Life Style; Male; Sedentary Behavior; Spain; Students; Universities; Young Adult
PubMed: 32397068
DOI: 10.3390/ijerph17093272 -
Frontiers in Immunology 2022Two related lifestyle behaviors associated with sleep disturbance are sedentary behavior and physical exercise participation. We aimed to use a population-based study to...
BACKGROUND
Two related lifestyle behaviors associated with sleep disturbance are sedentary behavior and physical exercise participation. We aimed to use a population-based study to disentangle the relationships between sedentary behavior, exercise, and sleep disturbance based on blood-cell-based inflammatory biomarkers.
METHODS
A total of 22,599 participants from the National Health and Nutrition Examination Survey (NHANES) were included in the analyses. Sleep disturbance was assessed according to the NHANES questionnaire. Exercise participation ansd sedentary behavior were evaluated by the global physical activity questionnaire. The inflammatory biomarkers in the examination were white blood cell (WBC) count, neutrophil count (NEU), neutrophil-to-lymphocyte ratio (NLR), and systemic immune inflammation index (SII). A complex multistage sampling design and weighted multivariable logistic regression were applied for further analysis. Mediation models were constructed to figure out the mediating role of inflammatory biomarkers.
RESULTS
The weighted prevalence of sleep disturbance was 24.17%. Sedentary behavior and exercise were associated with sleep disturbance after full adjustment [for sedentary behavior, OR (95% CI): 1.261 (1.154, 1.377); for exercise, OR (95% CI): 0.849 (0.757, 0.953)]. In severe sedentary behavior groups, the mitigation effect of exercise on sleep disturbance was observed [OR (95% CI): 0.687 (0.551, 0.857)]. For the mechanism, strong associations were detected between inflammatory biomarkers and sleep disturbance. Mediation analysis showed that WBC, NEU, NLR, and SII mediated the statistical association between sedentary behavior and sleep disturbance with proportions (%) of 2.09, 2.27, 1.76, and 0.82, respectively.
CONCLUSIONS
Our data suggested that sedentary behavior was a risk factor for sleep disturbance. Blood-cell-based inflammatory biomarkers were an easily accessible and cost-effective strategy for identifying sleep disturbance and also significantly mediated the association between sedentary behavior and sleep disturbance. Exercise was proved to be effective in severe sedentary behavior groups to improve sleep disturbance symptoms, while the internal mechanism needed further exploration.
Topics: Humans; Sedentary Behavior; Nutrition Surveys; Mediation Analysis; Exercise; Biomarkers; Sleep
PubMed: 36713451
DOI: 10.3389/fimmu.2022.1080782 -
Applied Ergonomics Nov 2019The relationships between sedentary lifestyle, sitting behaviour, and low back pain (LBP) remain controversial. In this study, we investigated the relationship between...
The relationships between sedentary lifestyle, sitting behaviour, and low back pain (LBP) remain controversial. In this study, we investigated the relationship between back pain and occupational sitting habits in 64 call-centre employees. A textile pressure mat was used to evaluate and parameterise sitting behaviour over a total of 400 h, while pain questionnaires evaluated acute and chronic LBP. Seventy-five percent of the participants reported some level of either chronic or acute back pain. Individuals with chronic LBP demonstrated a possible trend (t-test not significant) towards more static sitting behaviour compared to their pain-free counterparts. Furthermore, a greater association was found between sitting behaviour and chronic LBP than for acute pain/disability, which is plausibly due to a greater awareness of pain-free sitting positions in individuals with chronic pain compared to those affected by acute pain.
Topics: Adult; Chronic Pain; Female; Humans; Low Back Pain; Male; Middle Aged; Occupational Diseases; Sedentary Behavior; Sitting Position; Surveys and Questionnaires
PubMed: 31422243
DOI: 10.1016/j.apergo.2019.102894 -
Nutricion Hospitalaria Apr 2019Mexico has reported in 2016 a combined prevalence of obesity and overweight of 33.2% in children. The objective of this work was to make a literature review of the... (Review)
Review
Mexico has reported in 2016 a combined prevalence of obesity and overweight of 33.2% in children. The objective of this work was to make a literature review of the factors associated with obesity in Mexican children, such as genetic factors, feeding patterns, sedentary lifestyle and gut microbiota. We found that in Mexican children SNP (single nucleotide polymorphism) is present in genes such as MC4R, FTO and ADRB1, associated with obesity, and that PON-1192 polymorphism increases the risk of suffering insulin resistance. On the other hand, the variant of the ADIPOR2 gene (rs11061971) protects Mexican children against obesity, as well as a greater number of copies of the AMY gene was found in children with normal weight. The evidence of the number of copies is very important, since the current diet of the Mexican population is rich in carbohydrates and fats, origin of a nutritional transition that includes sedentary activities and a high consumption of sugary drinks. The consumption of certain foods causes important changes in the gut microbiota that contribute to the development of obesity and insulin resistance. It has been found that Mexican children with obesity have a higher abundance of phylum Firmicutes and B. eggerhii bacteria. Therefore, as obesity is so diverse, it is essential to diversify the treatment in which government authorities, parents and health authorities should get involved, as well as reinforcing nutrition and healthy eating issues in primary education in the country in order to reverse the prevalence and prevent the development of other pathologies in Mexican children.
Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Mexico; Pediatric Obesity; Prevalence; Sedentary Behavior
PubMed: 30866635
DOI: 10.20960/nh.2116 -
Stroke and Vascular Neurology Jun 2018We review evidence concerning exercise for stroke prevention. Plausible biological reasons suggest that exercise would be important in preventing stroke. While... (Review)
Review
We review evidence concerning exercise for stroke prevention. Plausible biological reasons suggest that exercise would be important in preventing stroke. While definitive randomised controlled trials evaluating the impact of physical activity (PA) and exercise on preventing stroke and mortality are lacking, observational studies, small randomised controlled trials and meta-analyses have provided evidence that PA and exercise favourably modify stroke risk factors, including hypertension, dyslipidaemia, diabetes, sedentary lifestyle, obesity, excessive alcohol consumption and tobacco use. It is, therefore, important to understand the factors associated with poststroke PA/exercise and cardiorespiratory fitness. Positively associated factors include self-efficacy, social support and quality of patients' relationships with health professionals. Negatively associated factors include logistical barriers, medical comorbidities, stroke-related deficits, negative exercise beliefs, fear of falling, poststroke fatigue, arthropathy/pain and depression. Definitive research is needed to specify efficacious behavioural approaches to increase poststroke exercise. Effective techniques probably include physician endorsement of exercise programmesto patients, enhancement of patient-professional relationships, providing patients an exercise rationale, motivational interviewing, collaborative goal-setting with patients, addressing logistical concerns, social support in programsmes, structured exercise programming, individualised behavioural instruction, behavioural diary recording, reviewing behavioural consequences of exercise efforts, reinforcing successful exercise performance. Exercise programming without counselling may increase short-term activity; simple advice or information-giving is probably ineffective. Older patients or those with cognitive impairment may need increased structure, with emphasis on behaviour per se, versus self-regulation skills. We support the latest American Heart Association/American Stroke Association guidelines (2014) recommending PA and exercise for stroke prevention, and referral to behaviourally oriented programmes to improve PA and exercise.
Topics: Accidental Falls; Exercise; Fear; Humans; Sedentary Behavior; Stroke; United States
PubMed: 30191075
DOI: 10.1136/svn-2018-000155 -
BioMed Research International 2019The aim of our study was to explore the relation between physical activity, sedentary behavior, and the subjective and objective indicators of quality of life as well as...
The aim of our study was to explore the relation between physical activity, sedentary behavior, and the subjective and objective indicators of quality of life as well as life satisfaction among university students, whose education is related to different dimensions on health. Participants ( = 595) were invited to fill in a set of suitable questionnaires. The path analysis and linear regression were used to establish a relationship between the examined constructs. Only some types of physical activity have shown a positive relation with the quality of life; the study also revealed some age and gender regularities. Physical activity in the household was most positively correlated to the quality of life. The amount of leisure and transport physical activity decreased with age, and there were also gender differences regarding the intensity and type of physical activity. Sedentary behavior during the week related positively with the subjective quality of life and its intimacy dimension, but sedentary behavior at the weekends was negatively related to objective and subjective quality of life as well as dimensions including intimacy, safety, and communicative aspect of the quality of life. Neither physical activity nor sedentary behavior demonstrated a significant relation with the level of life satisfaction. The type of physical activity undertaken and its matching to the needs of the young person affected their objective and subjective quality of life. Those findings may have important implications for institutions responsible for promoting active lifestyle.
Topics: Adolescent; Adult; Exercise; Female; Health Status; Humans; Leisure Activities; Life Style; Male; Personal Satisfaction; Quality of Life; Sedentary Behavior; Students; Surveys and Questionnaires; Universities; Young Adult
PubMed: 31930143
DOI: 10.1155/2019/9791281 -
Clinical Nutrition ESPEN Aug 2022Sedentary behavior and physical inactivity may increase the risk of obesity. This systematic review and meta-analysis aimed to investigate: i) the prevalence/incidence... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Sedentary behavior and physical inactivity may increase the risk of obesity. This systematic review and meta-analysis aimed to investigate: i) the prevalence/incidence of sedentary behavior and physical inactivity, ii) the association of sedentary behavior and physical inactivity with obesity, and iii) the objective and subjective measures, diagnostic criteria, and cut-off points to estimate sedentary behavior and physical inactivity in adults and older adults with obesity.
METHODS
We conducted a systematic review and meta-analysis in PubMed, Scielo, Lilacs, and Cochrane Library databases. A meta-analysis of a random-effects model was performed to estimate the combined prevalence of sedentary behavior and physical inactivity and their association with obesity.
RESULTS
Twenty-three studies involving 638,000 adults and older adults were included in the systematic review. A meta-analysis was conducted with 111,851 individuals with obesity. The combined prevalence of sedentary behavior was 31% (95% CI, 23-41%), and physical inactivity was 43% (95% CI, 31-55%). Significant associations between obesity and sedentary behavior (OR 1.45, 95% CI, 1.21-1.75) and physical inactivity (OR 1.52, 95% CI, 1.23-1.87) were found. Nine studies have used objective measures to assess physical activity levels, such as accelerometers and pedometers, whereas fourteen applied subjective methods and self-reported questionnaires.
CONCLUSIONS
As expected, we found elevated rates of sedentary behavior and physical inactivity in individuals with obesity and a positive risk association. The wide range of objective and subjective measures, methods and cut-offs resulted in great variations of physical inactivity and sedentary behavior estimates.
TRIAL REGISTRATION
PROSPERO (CRD42016037747).
Topics: Aged; Humans; Obesity; Obesity, Abdominal; Prevalence; Sedentary Behavior
PubMed: 35871953
DOI: 10.1016/j.clnesp.2022.06.001