-
Nicotine & Tobacco Research : Official... Jan 2017Many studies report a positive association between smoking and mental illness. However, the literature remains mixed regarding the direction of this association. We... (Review)
Review
BACKGROUND
Many studies report a positive association between smoking and mental illness. However, the literature remains mixed regarding the direction of this association. We therefore conducted a systematic review evaluating the association of smoking and depression and/or anxiety in longitudinal studies.
METHODS
Studies were identified by searching PubMed, Scopus, and Web of Science and were included if they: (1) used human participants, (2) were longitudinal, (3) reported primary data, (4) had smoking as an exposure and depression and/or anxiety as an outcome, or (5) had depression and/or anxiety as the exposure and smoking as an outcome.
RESULTS
Outcomes from 148 studies were categorized into: smoking onset, smoking status, smoking heaviness, tobacco dependence, and smoking trajectory. The results for each category varied substantially, with evidence for positive associations in both directions (smoking to later mental health and mental health to later smoking) as well as null findings. Overall, nearly half the studies reported that baseline depression/anxiety was associated with some type of later smoking behavior, while over a third found evidence that a smoking exposure was associated with later depression/anxiety. However, there were few studies directly supporting a bidirectional model of smoking and anxiety, and very few studies reporting null results.
CONCLUSIONS
The literature on the prospective association between smoking and depression and anxiety is inconsistent in terms of the direction of association most strongly supported. This suggests the need for future studies that employ different methodologies, such as Mendelian randomization (MR), which will allow us to draw stronger causal inferences.
IMPLICATIONS
We systematically reviewed longitudinal studies on the association of different aspects of smoking behavior with depression and anxiety. The results varied considerably, with evidence for smoking both associated with subsequent depression and anxiety, and vice versa. Few studies supported a bidirectional relationship, or reported null results, and no clear patterns by gender, ethnicity, clinical status, length to follow-up, or diagnostic test. Suggesting that despite advantages of longitudinal studies, they cannot alone provide strong evidence of causality. Therefore, future studies investigating this association should employ different methods allowing for stronger causal inferences to be made, such as MR.
Topics: Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Humans; Prospective Studies; Sex Characteristics; Smoking; Tobacco Use Disorder
PubMed: 27199385
DOI: 10.1093/ntr/ntw140 -
Journal of Periodontal Research Oct 2017Cigarette smoking increases the risk of developing several systemic conditions including cancer, cardiovascular and pulmonary diseases. Cigarette smoking is also... (Review)
Review
Cigarette smoking increases the risk of developing several systemic conditions including cancer, cardiovascular and pulmonary diseases. Cigarette smoking is also detrimental to oral health as it increases the incidence and severity of oral cancer, periodontal diseases and peri-implantitis, as well as impacting negatively on the dental patients' response to therapy. Therefore, consideration of smoking behavior and recommendation of smoking cessation are important parts of dental treatment planning. However, cigarettes are no longer the most popular form of tobacco use among adolescents in the United States and globally. In recent years, tobacco smoking using a waterpipe ("hookah," "shisha") and use of electronic cigarettes (ECIGs) has increased significantly. Thus, dental clinicians likely will treat more patients who are waterpipe and/or ECIG users. Yet, the literature on the health effects of waterpipe and ECIGs use is sparse. Both waterpipe and ECIGs deliver the dependence-producing drug nicotine. Waterpipe tobacco smoking has been associated with periodontitis, dry socket, premalignant lesions, and oral and esophageal cancer. The health effects of long-term ECIG use are unknown. The purpose of this review is to inform healthcare professionals about waterpipes and ECIGs, highlight emerging evidence on the biological effects of these increasingly popular tobacco products, and introduce perspectives for dental patient management and future research.
Topics: Adolescent; Databases, Factual; Dry Socket; Electronic Nicotine Delivery Systems; Esophageal Neoplasms; Humans; Mouth Neoplasms; Oral Health; Periodontitis; Smoking; Smoking Cessation; Tobacco Products; Tobacco Smoking; United States; Water Pipe Smoking
PubMed: 28393367
DOI: 10.1111/jre.12458 -
Cardiovascular Diabetology Jul 2023We aimed to examine the association between smoking behavior change and risk of cardiovascular disease (CVD) incidence and mortality in patients with type 2 diabetes...
BACKGROUND
We aimed to examine the association between smoking behavior change and risk of cardiovascular disease (CVD) incidence and mortality in patients with type 2 diabetes mellitus (T2DM).
METHODS
This study used nationwide data from the Korean National Health Insurance System and included 349,137 T2DM patients who smoked. Smoking behavior changes were defined with five groups: quitters, reducers I (≥ 50% reduction), reducers II (20-50% reduction), sustainers (± 20%), and increasers (≥ 20% increase) from the number of cigarettes/day at the baseline.
RESULTS
During a median follow-up of 5.1 years, 6,514 cases of myocardial infarction (MI) (1.9%), 7,837 cases of ischemic stroke (IS) (2.2%), and 14,932 deaths (4.3%) were identified. Quitters had a significantly decreased risk of MI (adjusted hazard ratio [aHR] 0.80, 95% CI 0.75-0.86) and IS (aHR 0.80, 95% CI 0.75-0.85) compared to sustainers, whereas reducers did not have a significant association with the risk of MI (aHR 1.03, 95% CI 0.94-1.13) and IS (aHR 1.00, 95% CI 0.92-1.08) in reducer I. Quitters also had a lower all-cause and CVD mortality than sustainers.
CONCLUSIONS
Smoking cessation was associated with decreased CVD incidence, and all-cause and CVD mortality among T2DM patients. However, smoking reduction was not associated with decreased risks for these.
Topics: Humans; Incidence; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Smoking; Cardiovascular System; Myocardial Infarction; Ischemic Stroke
PubMed: 37516874
DOI: 10.1186/s12933-023-01930-4 -
Scientific Reports Aug 2023Smoking patients with diabetes mellitus (DM) are at greater risk of developing pneumonia. How smoking behavior changes affect the risk of pneumonia hospitalization,...
Smoking patients with diabetes mellitus (DM) are at greater risk of developing pneumonia. How smoking behavior changes affect the risk of pneumonia hospitalization, however, remains unclear. Therefore, we investigated the association between smoking behavior change and the risk of pneumonia hospitalization in patients with DM. From January 1, 2009 and December 31, 2018, we investigated the association between smoking behavior change and the risk of pneumonia hospitalization in patients with DM. A total of 332,798 adult patients with DM from the Korean National Health Insurance System database who underwent health screening examination between 2009 and 2012, and were smokers at the first health examination were included. During a mean follow-up of 4.89 years, 14,598 (4.39%) incident pneumonia hospitalization cases were identified. Reducers had a slightly increased risk of pneumonia hospitalization (aHR 1.06, 95% CI 1.01-1.10) compared to sustainers. Quitters did not have a significant association with incidence of pneumonia hospitalization. However, increasers had 13% higher risk of pneumonia hospitalization (aHR 1.13, 95% CI 1.07-1.18), regardless of whether initial smoking was light, moderate, or heavy. Our study showed that an increase in smoking intensity was associated with an increased risk of pneumonia hospitalization in people with DM. However, a protective effect of smoking reduction or cessation on pneumonia risk was not demonstrated.
Topics: Adult; Humans; Smoking; Smokers; Diabetes Mellitus; Hospitalization; Pneumonia
PubMed: 37648711
DOI: 10.1038/s41598-023-40658-9 -
Nicotine & Tobacco Research : Official... Feb 2023To systematically review the association between smoking behavior and obstructive sleep apnea (OSA). (Meta-Analysis)
Meta-Analysis
INTRODUCTION
To systematically review the association between smoking behavior and obstructive sleep apnea (OSA).
AIMS AND METHODS
PubMed, Medline, the Cochrane Library, EMBASE, and Scopus databases were used to conduct this review. The two researchers independently screened the literatures, conducted the quality assessment, and data extraction according to the inclusion and exclusion criteria. The RevMan 5.3 was used to analysis the apnea hypopnea index (AHI) index, min saturation of oxyhemoglobin (SaO2), Epworth Sleepiness Scale (ESS) score, and oxygen desaturation index (DOI) and publication bias analysis to assess the effect of smoking on OSA patients. Furthermore, we performed subgroup of the severity of OSA, different countries of sample origin (western countries or eastern countries), and pack-years (PYs < 10 or PYs ≥ 20) to analyze the heterogeneity.
RESULTS
Thirteen studies were included in this analysis that conformed to inclusion criteria and exclusion criteria. Totally 3654 smokers and 9796 non-smokers have participated. The meta-analysis of 13 studies demonstrated that AHI levels were significantly higher in smoker group compared with non-smoker, ESS scores were also significantly higher in smoker group compared with non-smoker, min SaO2 levels were obviously lower in smoker group compared with non-smoker, however, DOI levels hadn't significantly different between two groups. The subgroup analysis showed that there was an association between severe OSA, eastern countries, pack-years, and smoking.
CONCLUSIONS
Smoking behavior is a significant association with OSA. Heavy smokers with histories of more than 20 PYs were at a higher risk of OSA. Moreover, patient with severe OSA exhibited a significantly association with smoking compared with patients with mild or moderate OSA.
IMPLICATIONS
The relationship between smoking and OSA was controversial, especially, whether smoking increase or aggravate the risk of OSA. In our review and meta-analysis, we demonstrated that smoking behavior is a significant association with OSA. Heavy smokers with histories of more than 20 PYs were at a higher risk of OSA. Moreover, patient with severe OSA exhibited a significant association with smoking compared with patients with mild or moderate OSA. More prospective long-term follow-up studies about effect of quit smoking on OSA are recommended to establish the further relationship.
Topics: Humans; Smoking; Prospective Studies; Sleep Apnea, Obstructive; Tobacco Smoking; Non-Smokers
PubMed: 35922388
DOI: 10.1093/ntr/ntac126 -
Preventive Medicine Dec 2021Studies on parental smoking behavior have mostly been conducted for developed countries and show that current parental smoking is negatively associated with children's...
Studies on parental smoking behavior have mostly been conducted for developed countries and show that current parental smoking is negatively associated with children's current health. Using four waves of a Chilean longitudinal survey (Encuesta de Protección Social), we estimate probit and ordinary least squares models relating parents' self-report of their children's current health status to several covariates, including current parental smoking status and change (transitions) in parental smoking status across the waves of the survey. The data were collected in the years 2004, 2006, 2009, and 2015. The working sample includes 25,052 observations. The study revealed that parents' self-report of their children's current health status is strongly associated with current and past parental smoking status. Parents who smoke have an increased 11.17% probability of reporting that their children are in fair, poor, or very poor health status, when compared to non-smoking parents. The effect is stronger if the smoker is the mother, and it is exacerbated if she is less educated or unemployed/inactive. In addition, quitting smoking has a significant positive effect on children's reported health status, which is greater if the mother quits smoking. Cessation among mothers who are unemployed or inactive is also associated with a more positive assessment of their children's health status. The findings suggest that cessation programs may have health benefits not only for smoking parents, but also for their children. Improving coverage or establishing a national cessation program may have important present and future effects on population health and well-being.
Topics: Child; Child Health; Chile; Female; Health Status; Humans; Parents; Smoking
PubMed: 34506821
DOI: 10.1016/j.ypmed.2021.106792 -
International Journal of Environmental... Jul 2022Smoking is more common among individuals with mental health issues than those who do not have mental illnesses. In particular, among individuals with an anxiety...
Smoking is more common among individuals with mental health issues than those who do not have mental illnesses. In particular, among individuals with an anxiety disorder, a high prevalence of smoking has been found. Mood adjustment theory suggests that individuals with negative moods could adjust their moods depending on the type of television they watched. To understand this relationship better, we aim to examine how different television viewing can moderate the tendency of smoking behavior for individuals with an anxiety disorder. We used national U.S. survey data and concepts from the mood adjustment theory to answer our research questions. Our main contributions were to: (1) extend the mood adjustment theory by focusing on the association between a diagnosed mental disorder (i.e., anxiety) and risky behavior (i.e., smoking), and (2) examine the nuances of television genres by dividing entertainment television into excitement-valenced and ambiguously-valenced entertainment programs, along with information programs. The primary findings show that individuals with an anxiety disorder were more likely to smoke and this association was significantly attenuated when they watched cartoons, sports, and health information programs, but the positive association between an anxiety disorder and the extent of smoking was intensified when they watched drama, music, sci-fi, and television news. Patients with an anxiety disorder may take advantage of excitement-valenced entertainment programs and health-related information but need to be cautious in choosing ambiguously-valenced entertainment programs and news.
Topics: Anxiety Disorders; Drama; Humans; Leisure Activities; Smoking; Television
PubMed: 35954515
DOI: 10.3390/ijerph19159160 -
Cancer Epidemiology, Biomarkers &... Jan 2017The use of menthol in cigarettes and marketing is under consideration for regulation by the FDA. However, the effects of menthol on smoking behavior and carcinogen... (Comparative Study)
Comparative Study
BACKGROUND
The use of menthol in cigarettes and marketing is under consideration for regulation by the FDA. However, the effects of menthol on smoking behavior and carcinogen exposure have been inconclusive. We previously reported metabolomic profiling for cigarette smokers, and novelly identified a menthol-glucuronide (MG) as the most significant metabolite directly related to smoking. Here, MG is studied in relation to smoking behavior and metabolomic profiles.
METHODS
This is a cross-sectional study of 105 smokers who smoked two cigarettes in the laboratory one hour apart. Blood nicotine, MG, and exhaled carbon monoxide (CO) boosts were determined (the difference before and after smoking). Spearman correlation, χ, and ANCOVA adjusted for gender, race, and cotinine levels for menthol smokers assessed the relationship of MG boost, smoking behavior, and metabolic profiles. Multivariate metabolite characterization using supervised partial least squares-discriminant analysis (PLS-DA) was carried out for the classification of metabolomics profiles.
RESULTS
MG boost was positively correlated with CO boost, nicotine boost, average puff volume, puff duration, and total smoke exposure. Classification using PLS-DA, MG was the top metabolite discriminating metabolome of menthol versus nonmenthol smokers. Among menthol smokers, 42 metabolites were significantly correlated with MG boost, which linked to cellular functions, such as of cell death, survival, and movement.
CONCLUSIONS
Plasma MG boost is a new smoking behavior biomarker that may provide novel information over self-reported use of menthol cigarettes by integrating different smoking measures for understanding smoking behavior and harm of menthol cigarettes.
IMPACT
These results provide insight into the biological effect of menthol smoking. Cancer Epidemiol Biomarkers Prev; 26(1); 51-60. ©2016 AACR.
Topics: Adult; Age Factors; Biomarkers; Cigarette Smoking; Cross-Sectional Studies; Female; Humans; Male; Menthol; Metabolomics; Middle Aged; Multivariate Analysis; Nicotine; Reproducibility of Results; Risk Assessment; Sex Factors; Smoking
PubMed: 27628308
DOI: 10.1158/1055-9965.EPI-16-0124 -
Drug and Alcohol Dependence Feb 2020Recent findings suggest that overreliance on habit may be common in individuals diagnosed with addiction. To advance our understanding of habit in clinical samples and...
BACKGROUND
Recent findings suggest that overreliance on habit may be common in individuals diagnosed with addiction. To advance our understanding of habit in clinical samples and from behavioral measures, this study examines the interrelations between self-reported habit index for smoking and drinking as well as behavioral measures of intraindividual variability in smoking and drinking.
METHODS
Treatment-seeking heavy drinking smokers (N = 416) completed the Self-Report Habit Index (SRHI) adapted for both smoking and drinking. "Behavioral habitualness" was computed from the degree of intraindividual variability in patterns of smoking and drinking over the past month. Using the 28-day Timeline-Follow Back (TLFB) interview, we derived two measures of intraindividual variability: interclass correlation (ICC) and autocorrelation [AR(7) coefficients].
RESULTS
Self-report measures of habit were robustly associated with clinical severity of drinking and smoking with higher habit scores indicating greater severity of drinking and smoking, respectively. ICC and AR(7) coefficients, the behavioral measure of "patterness" and putative habit, were not associated with SRHI scores. While ICC for smoking was associated with higher nicotine dependence scores, this pattern was not found for drinking ICC and alcohol problem severity.
CONCLUSIONS
These results support the construct validity of the self-report measures of habit for smoking and drinking, as well an initial evaluation of behavioral measure of smoking "patterness" as a potential proxy for habit smoking. Because habit represents a complex phenotype with limited clinical translation, additional studies capturing a wider range of substance use severity and coupled with brain-based validation methods are warranted.
Topics: Adult; Alcohol Drinking; Cross-Sectional Studies; Female; Habits; Humans; Male; Middle Aged; Self Report; Smoking; Tobacco Smoking
PubMed: 31816490
DOI: 10.1016/j.drugalcdep.2019.107738 -
Chest Jun 2023Hypomethylation of the aryl hydrocarbon receptor repressor (AHRR) gene indicates long-term smoking exposure and might therefore be a monitor for smoking-induced disease...
BACKGROUND
Hypomethylation of the aryl hydrocarbon receptor repressor (AHRR) gene indicates long-term smoking exposure and might therefore be a monitor for smoking-induced disease risk. However, studies of individual longitudinal changes in AHRR methylation are sparse.
RESEARCH QUESTION
How does the recovery of AHRR methylation depend on change in smoking behaviors and demographic variables?
STUDY DESIGN AND METHODS
This study included 4,432 individuals from the Copenhagen City Heart Study, with baseline and follow-up blood samples and smoking information collected approximately 10 years apart. AHRR methylation at the cg05575921 site was measured in bisulfite-treated leukocyte DNA. Four smoking groups were defined: participants who never smoked (Never-Never), participants who formerly smoked (Former-Former), participants who quit during the study period (Current-Former), and individuals who smoked at both baseline and follow-up (Current-Current). Methylation recovery was defined as the increase in AHRR methylation between baseline and follow-up examination.
RESULTS
Methylation recovery was highest among participants who quit, with a median methylation recovery of 5.58% (interquartile range, 1.79; 9.15) vs 1.64% (interquartile range, -1.88; 4.96) in the Current-Current group (P < .0001). In individuals who quit smoking, older age was associated with lower methylation recovery (P < .0001). In participants who quit aged > 65 years, methylation recovery was 5.9% at 5.6 years after quitting; methylation recovery was 8.5% after 2.8 years for participants who quit aged < 55 years.
INTERPRETATION
AHRR methylation recovered after individuals quit smoking, and recovery was more pronounced and occurred faster in younger compared with older interim quitters.
Topics: Humans; Longitudinal Studies; Basic Helix-Loop-Helix Transcription Factors; Repressor Proteins; Smoking; DNA Methylation; Transcription Factors
PubMed: 36621758
DOI: 10.1016/j.chest.2022.12.036