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Journal of Cosmetic and Laser Therapy :... Nov 2016Steatocystoma multiplex is a well-recognized condition in which subjects develop dermal cysts generally inherited in an autosomal dominant fashion, though these can...
Steatocystoma multiplex is a well-recognized condition in which subjects develop dermal cysts generally inherited in an autosomal dominant fashion, though these can occur sporadically. This case report describes the successful treatment of a 51-year-old woman with steatocystomata limited to the face, who after two treatments with a fractionated ablative carbon dioxide laser remained free of cysts for three years. We conclude that this treatment should be considered as an efficient and effective treatment option for patients with steatocystoma multiplex.
Topics: Carbon Dioxide; Face; Female; Humans; Laser Therapy; Middle Aged; Patient Satisfaction; Steatocystoma Multiplex; Treatment Outcome
PubMed: 27183246
DOI: 10.1080/14764172.2016.1188212 -
Indian Journal of Dermatology 2017Pachyonychia Congenita (PC) refers to a group of autosomal dominant disorders with variable clinical presentations. While nail dystrophy and plantar keratoderma are the...
Pachyonychia Congenita (PC) refers to a group of autosomal dominant disorders with variable clinical presentations. While nail dystrophy and plantar keratoderma are the most consistent features in all the variants, a myriad of other manifestations has been observed. This report highlights a case of young female presenting with multiple asymptomatic cutaneous cysts associated with plantar kearatoderma and nail dystrophy. Similar nail changes were evident in her son also. Such clinical presentation, in corroboration with histopathological evaluation of the cutaneous cyst prompted us to make a diagnosis of Pachyonychia Congenita type II.
PubMed: 29263544
DOI: 10.4103/ijd.IJD_473_16 -
Indian Journal of Dermatology 2010
PubMed: 21063535
DOI: 10.4103/0019-5154.70690 -
Annals of Dermatology Dec 2008Steatocystoma is a benign adnexal tumor originating from the pilosebaceous duct junction which can be classified into two groups (steatocystoma simplex and steatocystoma...
Steatocystoma is a benign adnexal tumor originating from the pilosebaceous duct junction which can be classified into two groups (steatocystoma simplex and steatocystoma multiplex). Steatocystoma simplex, which presents as a solitary lesion, is very rare. Steatocystoma simplex occurs most commonly on the face and the case reported herein involving the scalp is extremely rare. A 49-year-old man presented for evaluation and treatment of a solitary papule on the right parietal scalp which had persisted for a period of 1 year. The histopathologic examination revealed a thin-walled cyst consisting of stratified squamous epithelium with hyaline cuticle that lacked a stratum granulosum. Based on clinical and histologic findings, we diagnosed this case as steatocystoma simplex of the scalp and report this rare case.
PubMed: 27303199
DOI: 10.5021/ad.2008.20.4.230 -
The Journal of Investigative Dermatology May 1964
Topics: Cholesteatoma; Dermoid Cyst; Female; Humans; Pathology; Steatocystoma Multiplex; Teratoma
PubMed: 14145861
DOI: 10.1038/jid.1964.83 -
Genes & Development Jun 2002Onset of type I keratin 17 (K17) synthesis marks the adoption of an appendageal fate within embryonic ectoderm, and its expression persists in specific cell types within...
Onset of type I keratin 17 (K17) synthesis marks the adoption of an appendageal fate within embryonic ectoderm, and its expression persists in specific cell types within mature hair, glands, and nail. We report that K17 null mice develop severe alopecia during the first week postbirth, correlating with hair fragility, alterations in follicular histology, and apoptosis in matrix cells. These alterations are incompletely penetrant and normalize starting with the first postnatal cycle. Absence of a hair phenotype correlates with a genetic strain-dependent compensation by related keratins, including K16. These findings reveal a crucial role for K17 in the structural integrity of the first hair produced and the survival of hair-producing cells. Given that identical inherited mutations in this gene can cause either pachyonychia congenita or steatocystoma multiplex, the features of this mouse model suggest that this clinical heterogeneity arises from a cell type-specific, genetically determined compensation by related keratins.
Topics: Age Factors; Alopecia; Animals; Apoptosis; Blotting, Western; Crosses, Genetic; Disease Models, Animal; Genetic Techniques; Genotype; In Situ Nick-End Labeling; Keratins; Mice; Mice, Inbred C57BL; Models, Genetic; Phenotype; Recombination, Genetic; Skin; Species Specificity; Time Factors
PubMed: 12050118
DOI: 10.1101/gad.979502 -
Annals of Dermatology Oct 2011Steatocystoma multiplex (SM) is an uncommon disorder of the pilosebaceous unit characterized by the development of numerous sebum-containing dermal cysts which rarely...
Steatocystoma multiplex (SM) is an uncommon disorder of the pilosebaceous unit characterized by the development of numerous sebum-containing dermal cysts which rarely involves the scalp. Here, we report a case of a 50-year-old man with multiple cystic nodules and alopecic patches on his scalp. On histopathological examination, the folded cyst was found to be lined by stratified squamous epithelium, while flattened sebaceous gland cells were identified in the cystic wall. Pigment casts were present in the hair papillae and perifollicular regions, suggesting trichotillomania as a possible cause of the observed alopecia. This case appears to represent an unusual clinical manifestation of SM.
PubMed: 22148065
DOI: 10.5021/ad.2011.23.S2.S258 -
Journal of Surgical Case Reports Oct 2020Steatocystoma is a rare, benign cyst that mostly originates from a dermal sebaceous gland. It can be divided into steatocystoma multiplex-with multiple locations-and...
Steatocystoma is a rare, benign cyst that mostly originates from a dermal sebaceous gland. It can be divided into steatocystoma multiplex-with multiple locations-and steatocystoma simplex occurring at a single site. The lesion is mostly located on the skin but can be found on other locations as well. This is the first case report of steatocystoma simplex that was found in the palate of a 37-year-old male. After resection with small safety margins and local wound dressing, no recurrence was detected during a follow-up of 1.5 years.
PubMed: 33072253
DOI: 10.1093/jscr/rjaa347 -
Annals of Dermatology Oct 2018
PubMed: 33911497
DOI: 10.5021/ad.2018.30.5.633 -
Dermatology Online Journal Mar 2005A 70-year-old man presents with multiple asymptomatic, yellow to skin-colored firm papules scattered on the scalp; the lesions had been present for about 30 years....
A 70-year-old man presents with multiple asymptomatic, yellow to skin-colored firm papules scattered on the scalp; the lesions had been present for about 30 years. Histological findings are consistent with the diagnosis of steatocystoma. We review the English-language literature of the published cases of localized forms of steatocystoma multiplex.
Topics: Aged; Epidermal Cyst; Humans; Male; Scalp Dermatoses
PubMed: 15748563
DOI: No ID Found