-
Ultraschall in Der Medizin (Stuttgart,... Apr 2018The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast...
The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications.
Topics: Adult; Contrast Media; Female; Humans; Image Enhancement; Liver; Liver Neoplasms; Male; Phospholipids; Practice Guidelines as Topic; Sulfur Hexafluoride; Ultrasonography
PubMed: 29510439
DOI: 10.1055/a-0586-1107 -
American Journal of Veterinary Research Jul 2021To compare qualitative features and quantitative parameters of 2 contrast agents (sulfur hexafluoride microbubbles [SHM; SonoVue] and perfluorobutane [PFB; Sonazoid])...
OBJECTIVE
To compare qualitative features and quantitative parameters of 2 contrast agents (sulfur hexafluoride microbubbles [SHM; SonoVue] and perfluorobutane [PFB; Sonazoid]) for performance of contrast-enhanced ultrasonography (CEUS) of the pancreas in dogs.
ANIMALS
8 healthy Beagles.
PROCEDURES
In a crossover study design, CEUS of the pancreas was performed twice in each dog, once with SHM and once with PFB, in random order with at least 3 days between examinations. The recorded cine images were qualitatively assessed for homogeneity of pancreatic enhancement and conspicuity of the pancreatic signal relative to the background. For the quantitative assessment, circular regions of interest were placed over the pancreatic body, and a time-intensity curve was obtained. For each region of interest, CEUS parameters including peak intensity (PI), time to peak pancreatic enhancement, area under the curve (AUC), and wash-in rate were obtained.
RESULTS
The homogeneity of the pancreatic parenchyma was not significantly different between contrast agents. The signal conspicuity relative to background noise was significantly higher with PFB than with SHM. Mean values of PI, wash-in rate, and AUC were significantly higher with PFB than with SHM. Time to peak enhancement was not significantly different between contrast agents.
CONCLUSIONS AND CLINICAL RELEVANCE
Pancreatic CEUS with SHM and PFB produced similar homogeneity scores, but only PFB provided excellent signal conspicuity. Perfluorobutane produced higher values of PI, wash-in rate, and AUC. Findings indicated that PFB can provide homogeneous and strong enhancement of the pancreas during CEUS in healthy dogs and that pancreatic CEUS parameter values differ with the contrast agent used.
Topics: Animals; Contrast Media; Cross-Over Studies; Dogs; Fluorocarbons; Microbubbles; Pancreas; Phospholipids; Sulfur Hexafluoride; Ultrasonography
PubMed: 34166085
DOI: 10.2460/ajvr.82.7.538 -
Thorax Apr 2021Multiple breath washout (MBW) using sulfur hexafluoride (SF) has the potential to reveal ventilation heterogeneity which is frequent in patients with obstructive lung...
BACKGROUND
Multiple breath washout (MBW) using sulfur hexafluoride (SF) has the potential to reveal ventilation heterogeneity which is frequent in patients with obstructive lung disease and associated small airway dysfunction. However, reference data are scarce for this technique and mostly restricted to younger cohorts. We therefore set out to evaluate the influence of anthropometric parameters on SF-MBW reference values in pulmonary healthy adults.
METHODS
We evaluated cross-sectional data from 100 pulmonary healthy never-smokers and smokers (mean 51 (SD 20), range 20-88 years). Lung clearance index (LCI), acinar (S) and conductive (S) ventilation heterogeneity were derived from triplicate SF-MBW measurements. Global ventilation heterogeneity was calculated for the 2.5% (LCI) and 5% (LCI) stopping points. Upper limit of normal (ULN) was defined as the 95th percentile.
RESULTS
Age was the only meaningful parameter influencing SF-MBW parameters, explaining 47% (CI 33% to 59%) of the variance in LCI, 32% (CI 18% to 47%) in S and 10% (CI 2% to 22%) in S. Mean LCI increases from 6.3 (ULN 7.4) to 8.8 (ULN 9.9) in subjects between 20 and 90 years. Smoking accounted for 2% (CI 0% to 8%) of the variability in LCI, 4% (CI 0% to 13%) in S and 3% (CI 0% to 13%) in S.
CONCLUSION
SF-MBW outcome parameters showed an age-dependent increase from early adulthood to old age. The effect was most pronounced for global and acinar ventilation heterogeneity and smaller for conductive ventilation heterogeneity. No influence of height, weight and sex was seen. Reference values can now be provided for all important SF-MBW outcome parameters over the whole age range.
TRIAL REGISTRATION NUMBER
NCT04099225.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anthropometry; Breath Tests; Cross-Sectional Studies; Female; Healthy Volunteers; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Reference Values; Respiratory Function Tests; Smokers; Sulfur Hexafluoride
PubMed: 33593931
DOI: 10.1136/thoraxjnl-2020-214717 -
ERJ Open Research Oct 2019Multiple-breath washout (MBW) can be performed with different gases (sulfur hexafluoride (SF) and nitrogen (N)) and different devices, all of which give discrepant...
UNLABELLED
Multiple-breath washout (MBW) can be performed with different gases (sulfur hexafluoride (SF) and nitrogen (N)) and different devices, all of which give discrepant results. This study aimed to confirm previously reported differences and explore factors influencing discrepant results; equipment factors or the physical properties of gases used.
METHODS
Healthy controls (HCs) and participants with cystic fibrosis (CF) completed MBW trials on two commercially available devices (Exhalyzer D (N) and Innocor (SF)). Simultaneous washout of both gases at the same time on the commercial equipment and simultaneous washouts using a respiratory mass spectrometer (RMS) were completed in subsets. Primary outcomes were lung clearance index (LCI), breath number and time required to washout.
RESULTS
Breath number was higher with N washout than SF in both HCs and patients with CF, whether washouts were completed individually or simultaneously. The difference was greater in more advanced disease, largely caused by differences in the final part of the washout. Results from commercial devices were similar to those obtained with the RMS.
CONCLUSIONS
N MBW results were higher than SF MBW, with some of the largest differences reported to date being observed. The biggest impact was at the end of the washout and this was even the case when gases were washed out simultaneously. N and SF MBW results are inherently different and should be considered as independent measurements.
PubMed: 31720295
DOI: 10.1183/23120541.00234-2018 -
Medicina (Kaunas, Lithuania) Nov 2023: This review paper highlights the key alternatives to the blue dye/radioisotope method of sentinel lymph node biopsy (SLNB). It analyses the research available on these... (Review)
Review
: This review paper highlights the key alternatives to the blue dye/radioisotope method of sentinel lymph node biopsy (SLNB). It analyses the research available on these alternative methods and their outcomes compared to the traditional techniques. : This review focused on fifteen articles, of which five used indocyanine green (ICG) as a tracer, four used magnetic tracers, one used one-step nucleic acid amplification (OSNA) and Metasin (quantitative reverse transcriptase-polymerase chain reaction), one used the photosensitiser talaporfin sodium, one used sulphur hexafluoride gas microbubbles, one used CT-guided lymphography and two focused on general SLNB technique reviews. : Of the 15 papers analysed, the sentinel node detection rates were 69-100% for indocyanine green, 91.67-100% for magnetic tracers, 81% for talaporfin sodium, 9.3-55.2% for sulphur hexafluoride gas microbubbles, 90.5% for CTLG and 82.7-100% for one-step nucleic acid amplification. : Indocyanine green fluorescence (ICG) and magnetic tracers have been proven non-inferior to traditional blue dye and isotope regarding SLNB localisation. Further studies are needed to investigate the use of these techniques in conjunction with each other and the possible use of language learning models. Dedicated studies are required to assess cost efficacy and longer-term outcomes.
Topics: Humans; Female; Sentinel Lymph Node Biopsy; Indocyanine Green; Lymphatic Metastasis; Sulfur Hexafluoride; Sentinel Lymph Node; Breast Neoplasms; Nucleic Acids; Lymph Nodes
PubMed: 38138180
DOI: 10.3390/medicina59122077 -
Acta Ophthalmologica Nov 2018Symptomatic vitreomacular adhesion (sVMA) is defined as visual loss secondary to foveal damage from vitreomacular traction (VMT) and includes isolated VMT, impending... (Review)
Review
Symptomatic vitreomacular adhesion (sVMA) is defined as visual loss secondary to foveal damage from vitreomacular traction (VMT) and includes isolated VMT, impending macular hole (MH), and full-thickness MH with persisting vitreous attachment. Management options include pars plana vitrectomy (PPV), intravitreal ocriplasmin, intravitreal gas injection or observation. This synthesis of the literature aimed to assess the safety and efficacy of intravitreal gas for sVMA. Articles describing patients with VMT or MH treated with intravitreal expansile gas were selected by systematic literature review using MEDLINE, EMBASE, and the Cochrane Database of Controlled Trials (CENTRAL) up to September 2016. The main outcomes at 1 month and final review were logarithm of the minimum angle of resolution (logMAR) visual acuity (VA), anatomical success (absence of both VMT and MH, without PPV) and adverse events (AEs). The intended comparator was observation. Nine of 106 identified articles were eligible, and none were randomized controlled trials. The mean VA of 91 eyes improved from 0.55 (Snellen equivalent 6/21) to 0.48 (6/18) logMAR at 1 month and to 0.35 (6/13) logMAR at final review. The mean VA at final review, prior to a vitrectomy, was 0.42 (6/16). Anatomic success was 48% at 1 month and 57% at final review. The reported AEs comprised retinal detachment in two highly myopic eyes. Intravitreal gas injection can relieve sVMA. Larger controlled studies are needed to determine safety and efficacy relative to observation, ocriplasmin, or vitrectomy.
Topics: Endotamponade; Fluorocarbons; Humans; Intravitreal Injections; Prone Position; Retinal Diseases; Sulfur Hexafluoride; Vitreous Detachment
PubMed: 28857483
DOI: 10.1111/aos.13547 -
American Journal of Veterinary Research Sep 2021To investigate the efficacy of a phospholipid-stabilized sulfur hexafluoride microsphere (SHM) contrast agent and water for hydrosonography of the upper portion of the...
Efficacy of a phospholipid-stabilized sulfur hexafluoride microsphere contrast agent and water for hydrosonography of the upper portion of the gastrointestinal tract in dogs.
OBJECTIVE
To investigate the efficacy of a phospholipid-stabilized sulfur hexafluoride microsphere (SHM) contrast agent and water for hydrosonography of the upper portion of the gastrointestinal tract of dogs.
ANIMALS
12 healthy adult Beagles.
PROCEDURES
In a crossover study, each dog was anesthetized and underwent noncontrast ultrasonography then hydrosonography following administration of tap water (30 mL/kg) without (water method) or with SHM (0.1 mL; SHM method) via an orogastric tube. There were at least 3 days between hydrosonographic procedures. Wall thickness, wall layer definition, conspicuity of the mucosal-luminal interface, and image quality were evaluated separately in the near and far fields for the gastric cardia, body, and pylorus and descending duodenum and compared among the 3 scanning methods.
RESULTS
Mean wall thickness measurements did not differ significantly between the water and SHM methods at any location except the far-field gastric cardia where the mean wall thickness for the SHM method was less than that for the water method. In general, the SHM method improved wall layer definition and conspicuity of the mucosal-luminal interface of structures in the near field, compared with noncontrast method. The water and SHM methods both resulted in superior image quality relative to the noncontrast method for the near-field gastric cardia, far-field gastric cardia, and far-field duodenum.
CONCLUSIONS AND CLINICAL RELEVANCE
Results indicated that, for dogs, gastrointestinal hydrosonography by use of the SHM method improved wall layer definition and mucosal conspicuity, particularly in near-field images of the upper portion of the gastrointestinal tract.
Topics: Animals; Contrast Media; Cross-Over Studies; Dogs; Gastrointestinal Tract; Microspheres; Phospholipids; Sulfur Hexafluoride; Water
PubMed: 34432515
DOI: 10.2460/ajvr.82.9.712 -
JACC. Cardiovascular Imaging Jan 2013
Topics: Contrast Media; Coronary Artery Disease; Echocardiography, Doppler; Echocardiography, Stress; Female; Fractional Flow Reserve, Myocardial; Humans; Male; Myocardial Perfusion Imaging; Phospholipids; Sulfur Hexafluoride; Ventricular Function, Left
PubMed: 23219413
DOI: 10.1016/j.jcmg.2012.10.008