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Metabolites Jul 2021Pursh and L. are two common species within the Scrophulariaceae family that are endemic to North America. Historically, these species were used by indigenous peoples...
Pursh and L. are two common species within the Scrophulariaceae family that are endemic to North America. Historically, these species were used by indigenous peoples and colonialists to treat sunburn, sunstroke, frostbite, edema, as well as for blood purification, and in women's health. Several iridoid and phenylethanoid/phenylpropanoid glycosides detected in these species, such as harpagoside and verbascoside, possess anti-inflammatory and anti-nociceptive properties. Due to the presence of anti-inflammatory metabolites and the historical uses of these species, we performed a two-year field study to determine the optimal production of these important compounds. We subjected the plants to shade treatment and analyzed differences in the metabolite composition between the two species and each of their leaves, stems, and roots at various times throughout the growing seasons. We determined that plants grown in full sun produced 0.63% harpagoside per dried weight in their leaves compared to shade-grown plants (0.43%). Furthermore, accumulated more harpagoside than (0.24%). We also found that verbascoside accumulated in the leaves of and as the growing season progressed, while the production of this metabolite remained mostly seasonally unchanged in the roots of both species.
PubMed: 34357358
DOI: 10.3390/metabo11070464 -
BMC Public Health Dec 2015Injuries are a major cause of childhood morbidity and mortality worldwide. We aimed to determine the magnitude and characteristics of child injuries in Egypt and to...
BACKGROUND
Injuries are a major cause of childhood morbidity and mortality worldwide. We aimed to determine the magnitude and characteristics of child injuries in Egypt and to identify the associated risk factors.
METHODS
A community-based, cross-sectional survey was conducted over 27 Egyptian governorates from June to October, 2011. The target population was 1977 households with children aged 0-18 years who had experienced accidental injuries.
RESULTS
In the 6-month period before the investigation, 1576 injuries were reported in 1472 children from a sample population of 1399 households (response rate 70.8 %). Falls (25 %) and burn injuries (20.3 %) were the most common accidental injuries. The incidence of these injuries was significantly higher among boys (57.2 %) than girls and in children aged 2-6 years (70 %) compared with older and younger children. The five main causes of injuries were wounds (30.6 %), fractures (28.7 %), burns (20.3 %), swallowing a foreign body (8.4 %) and accidentally ingesting a poison (7.8 %). Injuries from drowning (n = 27), animal bites (n = 22) and sunstroke (n = 20) mostly occurred in rural children, accounting for 65 %, 54.4 % and 52 %, respectively, of all injuries in rural children. Home and its immediate surroundings (64.4 %) was the most common setting for injuries. Maternal age, education and working status were also associated with childhood injuries (p < 0.05). Children of second and third birth order were at higher risk for injuries (p < 0.0001).
CONCLUSIONS
Childhood injuries account for a substantial healthcare burden in Egypt. Our findings emphasise the importance of developing national preventive programs designed to reduce the incidence of childhood injuries.
Topics: Accidental Falls; Accidents; Accidents, Home; Adolescent; Age Distribution; Burns; Child; Child, Preschool; Cross-Sectional Studies; Drowning; Egypt; Female; Fractures, Bone; Humans; Incidence; Infant; Infant, Newborn; Male; Morbidity; Residence Characteristics; Risk Factors; Rural Population; Sex Distribution; Surveys and Questionnaires; Wounds and Injuries
PubMed: 26680214
DOI: 10.1186/s12889-015-2613-5 -
British Journal of Cancer Nov 2006This review summarises some important new findings that implicate sphingosine-1-phosphate (S1P) as a potent tumorigenic and angiogenic agent released from cancerous... (Review)
Review
This review summarises some important new findings that implicate sphingosine-1-phosphate (S1P) as a potent tumorigenic and angiogenic agent released from cancerous tumours into the tumour microenvironment. Also explored is the novel concept that bioactive lipid signalling molecules, like S1P, can themselves be targets for rational drug design, thereby opening up an entire class of lipidomic-based therapeutics for oncology and other human diseases.
Topics: Animals; Antibodies, Monoclonal; Humans; Interleukin-6; Interleukin-8; Lysophospholipids; Mice; Models, Biological; Neoplasms; Sphingosine; Vascular Endothelial Growth Factor A
PubMed: 17024123
DOI: 10.1038/sj.bjc.6603400 -
Atlanta Medical and Surgical Journal Aug 1878
PubMed: 35824281
DOI: No ID Found -
The Homoeopathic Physician Feb 1890
PubMed: 37135563
DOI: No ID Found -
Microbiology and Molecular Biology... Mar 2001Five years after the publication of the second edition of the reference book Escherichia coli and Salmonella: Cellular and Molecular Biology, and on the eve of launching... (Review)
Review
Five years after the publication of the second edition of the reference book Escherichia coli and Salmonella: Cellular and Molecular Biology, and on the eve of launching a successor venture, the editors and colleagues examine where we stand in our quest for an understanding of these organisms. The main areas selected for this brief inquiry are genomics, evolution, molecular multifunctionality, functional backups, regulation of gene expression, cell biology, sensing of the environment, and ecology.
Topics: Biological Evolution; Escherichia coli; Gene Expression Regulation, Bacterial; Genetics, Population; Genome, Bacterial; Molecular Biology; Salmonella
PubMed: 11238988
DOI: 10.1128/MMBR.65.1.119-130.2001 -
Buffalo Medical and Surgical Journal Sep 1885
PubMed: 36665735
DOI: No ID Found -
The Indian Medical Gazette Nov 1898
PubMed: 29001936
DOI: No ID Found -
Hall's Journal of Health Sep 1890
PubMed: 36492599
DOI: No ID Found -
Western Journal of Medicine and Surgery Jul 1854
PubMed: 38210727
DOI: No ID Found