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The Journal of Clinical and Aesthetic... Jan 2021Clinicians employ several techniques to augment lips with hyaluronic acid (HA) filler. To the best of our knowledge, however, no previous study has documented the use of... (Review)
Review
Clinicians employ several techniques to augment lips with hyaluronic acid (HA) filler. To the best of our knowledge, however, no previous study has documented the use of a 4-mm 30-gauge needle in this context. This paper describes the anatomical rationale behind and practical application of such a needle applied very superficially in the vermillion border during lip augmentation. Using a 4-mm 30-gauge needle facilitates precise HA placement into the safer subcutaneous plane of the lip and lowers the pressure needed to extrude the filler, which might optimize patient comfort. This technique aims to increase the safety and predictability of lip augmentation with HA fillers. Credit is owed to Dr. Jean Louis Sebagh, who provided the inspiration to use the described needle for this evidence-based technique.
PubMed: 33584970
DOI: No ID Found -
Gland Surgery Apr 2023Oncoplastic breast reconstruction has allowed for the optimization of oncologic and reconstructive outcomes after breast-conserving surgery (BCS). Volume replacement... (Review)
Review
Oncoplastic breast reconstruction has allowed for the optimization of oncologic and reconstructive outcomes after breast-conserving surgery (BCS). Volume replacement procedures in oncoplastic reconstruction most commonly utilize regional pedicled flaps, though several studies have reported benefits to free tissue transfer for oncoplastic partial breast reconstruction in the immediate, delayed-immediate and delayed settings. Microvascular oncoplastic breast reconstruction is a useful technique in the appropriate patients with small-to-medium size breasts and larger tumor-to-breast ratios who desire to preserve breast size, those with a paucity of regional breast tissue and patients that wish to avoid chest wall and back scars. Several free flap options for partial breast reconstruction exist, including superficially-based abdominal flaps, medial thigh-based flaps, deep inferior epigastric artery perforator (DIEP) flaps and thoracodorsal artery-based flaps. However, special consideration should be given to preserving donor sites for potential future total autologous breast reconstruction with any flap choice that should be tailored to individual recurrence risk. Aesthetically placed incisions should take recipient vessel access into consideration which include the internal mammary vessels and perforators medially, and then intercostal, serratus branch and thoracodorsal vessels laterally. The utilization of a thin strip of lower abdominal tissue based on the superficial abdominal circulation allows for a well-concealed donor site with minimal morbidity and preservation of the abdominal donor site if future total autologous breast reconstruction is needed. Optimizing outcomes requires a team-based approach to appropriately design recipient and donor-site considerations while individualizing tumor and patient-specific plans.
PubMed: 37200929
DOI: 10.21037/gs-22-561 -
Neuropsychopharmacology : Official... Jul 2018Punishment involves learning about the relationship between behavior and its adverse consequences. Punishment is fundamental to reinforcement learning, decision-making... (Review)
Review
Punishment involves learning about the relationship between behavior and its adverse consequences. Punishment is fundamental to reinforcement learning, decision-making and choice, and is disrupted in psychiatric disorders such as addiction, depression, and psychopathy. However, little is known about the brain mechanisms of punishment and much of what is known is derived from study of superficially similar, but fundamentally distinct, forms of aversive learning such as fear conditioning and avoidance learning. Here we outline the unique conditions that support punishment, the contents of its learning, and its behavioral consequences. We consider evidence implicating GABA and monoamine neurotransmitter systems, as well as corticostriatal, amygdala, and dopamine circuits in punishment. We show how maladaptive punishment processes are implicated in addictions, impulse control disorders, psychopathy, anxiety, and depression and argue that a better understanding of the cellular, circuit, and cognitive mechanisms of punishment will make important contributions to next generation therapeutic approaches.
Topics: Animals; Avoidance Learning; Brain; Humans; Mental Disorders; Punishment
PubMed: 29703994
DOI: 10.1038/s41386-018-0047-3 -
Folia Morphologica 2022The lateral compartment of the leg, due to its distal and concurrent superficial positioning, is a multiple trauma site. Detailed knowledge of compartimentum lateralis...
BACKGROUND
The lateral compartment of the leg, due to its distal and concurrent superficial positioning, is a multiple trauma site. Detailed knowledge of compartimentum lateralis cruris (CLC) structure is crucial for physicians. Musculus peroneus longus (MPL) is located within the structures of the CLC most superficially. There is a lot of data on the morphology of the MPL but there is no publication analysing in detail its anatomy in the foetal period. The aim of the study was to determine the variability of metric and morphological parameters of MPL in a studied period of prenatal ontogenesis.
MATERIALS AND METHODS
The analysis included 207 human foetuses (101 males and 106 females) at calendar age from 113 to 222 days. The analysed material comes from the local anatomy collection. Foetuses were stored in typical preservation solutions. Access to the muscle was obtained on the basis of standard preparation techniques. The authors evaluated the metric parameters of the muscle showing the presence of variable dynamics of metric increments of the examined muscle in particular age classes.
RESULTS
In the studied period of prenatal ontogenesis, MPLs of the foetuses increased by about 60% in the length and width dimension and by about 100% in the thickness dimension. The topography of the initial and final muscle attachment was also evaluated. Statistically significant dimorphic differences were found in some aspects of muscle attachment topography.
CONCLUSIONS
The analysis of the place of the origin and insertion of MPL showed a relatively large variety of these features.
Topics: Female; Fetus; Humans; Leg; Male; Muscle, Skeletal; Pregnancy
PubMed: 33124032
DOI: 10.5603/FM.a2020.0129 -
Frontiers in Cell and Developmental... 2023Throughout the animal kingdom regenerative ability varies greatly from species to species, and even tissue to tissue within the same organism. The sheer diversity of... (Review)
Review
Throughout the animal kingdom regenerative ability varies greatly from species to species, and even tissue to tissue within the same organism. The sheer diversity of structures and mechanisms renders a thorough comparison of molecular processes truly daunting. Are "blastemas" found in organisms as distantly related as planarians and axolotls derived from the same ancestral process, or did they arise convergently and independently? Is a mouse digit tip blastema orthologous to a salamander limb blastema? In other fields, the thorough characterization of a reference model has greatly facilitated these comparisons. For example, the amphibian Spemann-Mangold organizer has served as an amazingly useful comparative template within the field of developmental biology, allowing researchers to draw analogies between distantly related species, and developmental processes which are superficially quite different. The salamander limb blastema may serve as the best starting point for a comparative analysis of regeneration, as it has been characterized by over 200 years of research and is supported by a growing arsenal of molecular tools. The anatomical and evolutionary closeness of the salamander and human limb also add value from a translational and therapeutic standpoint. Tracing the evolutionary origins of the salamander blastema, and its relatedness to other regenerative processes throughout the animal kingdom, will both enhance our basic biological understanding of regeneration and inform our selection of regenerative model systems.
PubMed: 37635872
DOI: 10.3389/fcell.2023.1206157 -
Frontiers in Physiology 2016Oomycetes are a family of eukaryotic microbes that superficially resemble fungi, but which are phylogenetically distinct from them. These organisms cause major global... (Review)
Review
Oomycetes are a family of eukaryotic microbes that superficially resemble fungi, but which are phylogenetically distinct from them. These organisms cause major global economic losses to agriculture and fisheries, with representative pathogens being Phytophthora infestans, the cause of late potato blight and Saprolegnia diclina, the instigator of "cotton molds" in fish. As in all eukaryotes, cytoplasmic Ca(2+) is a key second messenger in oomycetes, regulating life-cycle transitions, controlling motility and chemotaxis and, in excess, leading to cell-death. Despite this, little is known about the molecular mechanisms regulating cytoplasmic Ca(2+) concentrations in these organisms. Consequently, this review analyzed the presence of candidate calcium channels encoded within the nine oomycete genomes that are currently available. This revealed key differences between oomycetes and other eukaryotes, in particular the expansion and loss of different channel families, and the presence of a phylum-specific group of proteins, termed the polycystic kidney disease tandem ryanodine receptor domain (PKDRR) channels.
PubMed: 27092083
DOI: 10.3389/fphys.2016.00123