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British Heart Journal Nov 1978The cardiovascular system was examined in 19 cases of familial amyloid polyneuropathy. In a group of patients with neurological involvement, various cardiac...
The cardiovascular system was examined in 19 cases of familial amyloid polyneuropathy. In a group of patients with neurological involvement, various cardiac abnormalities were common, including orthostatic hypotension, prominent apex cardiographic A waves, abnormal apical systolic waves (bulges), systolic murmurs, mid-systolic clicks, QS waves, atrioventricular block, left bundlebranch block, and abnormalities of ejection time and pre-ejection period. Though there was one case with pronounced cardiac abnormality despite a normal neurological state, and though cardiovascular symptoms appeared later than neurological symptoms, the degree of cardiac involvement generally paralleled the severity of the neurological disorder.
Topics: Adult; Amyloidosis; Cardiovascular System; Electrocardiography; Female; Heart; Humans; Male; Middle Aged; Nervous System Diseases
PubMed: 718770
DOI: 10.1136/hrt.40.11.1288 -
Schweizer Archiv Fur Tierheilkunde Nov 2017A 7-year-old castrated male Labrador retriever was examined for a 10-day history of weakness and syncope. Physical examination revealed bradycardia and a grade III/VI...
A 7-year-old castrated male Labrador retriever was examined for a 10-day history of weakness and syncope. Physical examination revealed bradycardia and a grade III/VI left apical systolic heart murmur. Electrocardiography demonstrated bradycardia, absence of P waves and an atrio-ventricular nodal escape rhythm. Echocardiography revealed marked biatrial enlargement. Thoracic radiographs showed no evidence of pulmonary edema. Routine plasma biochemistry and electrolytes, basal serum cortisol, total thyroxin concentration, and complete blood count were within normal limits. Serum cardiac troponin I concentration was moderately increased. Serological examinations for antibodies against vector-borne diseases were negative. A pacemaker was implanted one month after the initial presentation due to worsening of the dog's clinical condition despite medical treatment. The dog remained asymptomatic for 18 months but was then re-presented with a gastric dilatation volvulus and subsequently euthanized. Necropsy and histology of the heart yielded a diagnosis of atrial cardiomyopathy.
Topics: Animals; Bradycardia; Cardiomyopathies; Dog Diseases; Dogs; Electrocardiography; Euthanasia, Animal; Fatal Outcome; Heart Atria; Heart Murmurs; Male; Orchiectomy; Pacemaker, Artificial; Troponin I
PubMed: 29128861
DOI: 10.17236/sat00134 -
British Medical Journal Oct 1975
Topics: Aged; Anemia; Aortic Valve Insufficiency; Arrhythmias, Cardiac; Female; Heart Auscultation; Heart Murmurs; Heart Valve Diseases; Humans; Male; Middle Aged; Mitral Valve Insufficiency
PubMed: 1182473
DOI: 10.1136/bmj.4.5988.69 -
Frontiers in Pediatrics 2019Cardiac involvement in PANS has not been clarified relying on the scientific literature available until today. It is known that streptococcal infections play a role in...
Cardiac involvement in PANS has not been clarified relying on the scientific literature available until today. It is known that streptococcal infections play a role in the etiology of a great number of diseases including Sydenham chorea and rheumatic fever, among others. Based on the suspected pathogenesis of PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) reported in the medical literature, we decided to investigate the cardiologic involvement in children with a recent PANS/PANDAS diagnosis. The study population satisfies PANS (1) and PANDAS (2) criteria of diagnoses. Cardiologic assessment was performed through clinical examination, electrocardiography, and echocardiography. In the selected pediatric population, a significant number of children presented mitral valve involvement, systolic murmurs and electrocardiographic abnormalities. High ASLOT levels did not seem to be associated to a cardiac involvement. Often PANS is difficult to diagnose because it is little known by physicians and most of the cardiologic findings described in this study are common among the healthy pediatric population. Also, ASLOT levels seems not to be predictive of cardiac involvement. Furthermore, the existence of PANDAS as a clinical entity is associated with a group of anti-neuronal autoantibodies found in Sydenham chorea is still controversial. We recommend a complete cardiologic evaluation in those children who meet the PANS/PANDAS diagnostic criteria.
PubMed: 31632938
DOI: 10.3389/fped.2019.00395 -
British Heart Journal Jun 1986The prevalence and clinical importance of false tendons were studied in 488 consecutive patients referred for echocardiography. Two hundred and eighty three (58%)...
The prevalence and clinical importance of false tendons were studied in 488 consecutive patients referred for echocardiography. Two hundred and eighty three (58%) patients had acquired heart disease, 91 (19%) had congenital heart disease, and 114 (23%) had normal hearts. Sixty six patients with normal hearts had innocent systolic murmurs and one had recurrent ventricular tachycardia. The overall prevalence of false tendons was 25% compared with 1.6% in a retrospective analysis of 763 cross sectional echocardiograms. When patients with innocent murmurs were excluded from statistical analysis, there was no significant difference in the prevalence of these tendons between children and adults, boys and girls, men and women, or between patients with acquired or congenital heart disease and normal patients. The prevalence of false tendons in patients with dilated left ventricles (57%), however, resembled that seen in necropsy studies. The prevalence of false tendons in patients with an innocent systolic murmur was 76% in children and 40% in adults, with an overall prevalence of 52%. False tendons are a common echocardiographic finding of no clinical importance except for their possible role in the genesis of innocent murmurs and ventricular arrhythmias. The echocardiographic detection of false tendons increases considerably when these structures are specifically sought and in conditions that result in left ventricular chamber dilatation.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chordae Tendineae; Echocardiography; Female; Heart Defects, Congenital; Heart Murmurs; Heart Ventricles; Humans; Infant; Infant, Newborn; Male; Middle Aged; Myocardium; Prospective Studies; Purkinje Fibers
PubMed: 3718798
DOI: 10.1136/hrt.55.6.587 -
British Medical Journal Jan 1943
PubMed: 20784621
DOI: 10.1136/bmj.1.4278.8 -
California State Journal of Medicine Mar 1914
PubMed: 18736210
DOI: No ID Found -
Journal of the American College of... Sep 2014Blood flow in the intestinal arteries is reduced in patients with stable heart failure (HF) and relates to gastrointestinal (GI) symptoms and cardiac cachexia.
BACKGROUND
Blood flow in the intestinal arteries is reduced in patients with stable heart failure (HF) and relates to gastrointestinal (GI) symptoms and cardiac cachexia.
OBJECTIVES
The aims of this study were to measure arterial intestinal blood flow and assess its role in juxtamucosal bacterial growth, GI symptoms, and cachexia in patients with HF.
METHODS
A total of 65 patients and 25 controls were investigated. Twelve patients were cachectic. Intestinal blood flow and bowel wall thickness were measured using ultrasound. GI symptoms were documented. Bacteria in stool and juxtamucosal bacteria on biopsies taken during sigmoidoscopy were studied in a subgroup by fluorescence in situ hybridization. Serum lipopolysaccharide antibodies were measured.
RESULTS
Patients showed 30% to 43% reduced mean systolic blood flow in the superior and inferior mesenteric arteries and celiac trunk (CT) compared with controls (p < 0.007 for all). Cachectic patients had the lowest blood flow (p < 0.002). Lower blood flow in the superior mesenteric artery and CT was correlated with HF severity (p < 0.04 for all). Patients had more feelings of repletion, flatulence, intestinal murmurs, and burping (p < 0.04). Burping and nausea or vomiting were most severe in patients with cachexia (p < 0.05). Patients with lower CT blood flow had more abdominal discomfort and immunoglobulin A-antilipopolysaccharide (r = 0.76, p < 0.02). Antilipopolysaccharide response was correlated with increased growth of juxtamucosal but not stool bacteria. Patients with intestinal murmurs had greater bowel wall thickness of the sigmoid and descending colon, suggestive of edema contributing to GI symptoms (p < 0.05). In multivariate regression analysis, lower blood flow in the superior mesenteric artery, CT (p < 0.04), and inferior mesenteric artery (p = 0.056) was correlated with the presence of cardiac cachexia.
CONCLUSIONS
Intestinal blood flow is reduced in patients with HF. This may contribute to juxtamucosal bacterial growth and GI symptoms in patients with advanced HF complicated by cachexia.
Topics: Aged; Bacteria; Cachexia; Chronic Disease; Female; Gastrointestinal Diseases; Heart Failure; Humans; Intestinal Mucosa; Intestines; Male; Middle Aged; Prospective Studies; Regional Blood Flow
PubMed: 25212642
DOI: 10.1016/j.jacc.2014.06.1179 -
Cardiovascular Journal of Africa 2011Pregnancy is associated with major haemodynamic and cardiac changes, which can mimic or precipitate cardiac diseases. There is a paucity of this kind of data among...
INTRODUCTION
Pregnancy is associated with major haemodynamic and cardiac changes, which can mimic or precipitate cardiac diseases. There is a paucity of this kind of data among pregnant Nigerian women. This study was aimed at describing the cardiovascular and electrocardiographic changes found among healthy pregnant Nigerian women.
METHODS
This was an age-matched control study of 69 consecutive normal pregnant and 70 healthy non-pregnant controls. The study protocol included history, physical examination and 12-lead electrocardiography.
RESULTS
Diastolic blood pressure < 60 mmHg was significantly commoner among pregnant subjects than controls (64.7 vs 24.3%, respectively, p < 0.005). Mean heart rate was higher among pregnant women (88.34 ± 11.46 bpm) than the controls (75.16 ± 12.22 bpm, p = 0.020). Pregnant subjects also had a higher proportion of left ventricular hypertrophy (LVH) (10.2 vs 0%, p < 0.05) than non-pregnant controls. Abnormal cardiac findings included a loud second heart sound (P(2)), missed beats and systolic murmurs (41.2% in pregnant subjects vs 12.9% in non-pregnant controls, p < 0.05). Negroid-pattern ST-segment elevation was commoner among controls (24.3%) than pregnant subjects (2.9%, p < 0.005). Arrhythmias were rare among the study participants.
CONCLUSION
Significant findings on examination were low diastolic blood pressure and a systolic ejection murmur. However, ECG changes showed a normal frontal-plane QRS axis, normal PR interval, significantly rare normal Negroidpattern ST elevation, significant LVH based on Araoye RI > 12 mm and a rarity of all forms of arrhythmias. These data may help resolve some cardiac diagnostic difficulties during pregnancy.
Topics: Adult; Blood Pressure; Cross-Sectional Studies; Electrocardiography; Female; Heart Rate; Humans; Nigeria; Pregnancy; Pregnancy Trimesters; Ventricular Function; Young Adult
PubMed: 21556448
DOI: 10.5830/cvja-2010-043 -
Pediatric Nephrology (Berlin, Germany) Apr 2024A 3-year-old female patient with no significant medical history presented to her pediatrician with foamy urine. Initial testing revealed moderate proteinuria on...
A 3-year-old female patient with no significant medical history presented to her pediatrician with foamy urine. Initial testing revealed moderate proteinuria on qualitative testing, although she was incidentally noted to have severe hypertension (240/200 mmHg). Physical examination of the carotid and femoral areas revealed significant systolic vascular murmurs. Labs showed elevated serum creatinine, hypokalemia, metabolic alkalosis, elevated renin and aldosterone and hypercalciuria. Echocardiography identified ventricular hypertrophy. Computed tomography (CT) of the abdomen and magnetic resonance angiography of the head showed multiple tortuous or interrupted arteries and multiple calcifications in the renal sinus area. B-mode ultrasonography suggested thickening of the carotid and femoral artery walls, with numerous spotted calcifications. Genetic testing revealed that ABCC6 had a complex heterozygous mutation (exon 24: c.3340C > T and intron 30: c.4404-1G > A). Our panel of experts reviewed the evaluation of this patient with hypertension, proteinuria, hypercalciuria, and vascular abnormalities as well as the diagnosis and appropriate management of a rare disease.
Topics: Female; Humans; Child, Preschool; Hypercalciuria; Hypertension; Hypokalemia; Genetic Testing; Proteinuria
PubMed: 38165475
DOI: 10.1007/s00467-023-06230-3