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Frontiers in Public Health 2023The hepatotoxicity of exposure to a single heavy metal has been examined in previous studies. However, there is limited evidence on the association between heavy metals...
OBJECTIVE
The hepatotoxicity of exposure to a single heavy metal has been examined in previous studies. However, there is limited evidence on the association between heavy metals mixture and non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD). This study aims to investigate the associations of 13 urinary metals, individually and jointly, with NAFLD, MAFLD, and MAFLD components.
METHODS
This study included 5,548 adults from the National Health and Nutrition Examination Survey (NHANES) 2003-2018. Binary logistic regression was used to explore the associations between individual metal exposures and MAFLD, NAFLD, and MAFLD components. Bayesian kernel machine regression (BKMR) and Quantile-based g-computation (QGC) were used to investigate the association of metal mixture exposure with these outcomes.
RESULTS
In single metal analysis, increased levels of arsenic [OR 1.09 (95%CI 1.03-1.16)], dimethylarsinic acid [1.17 (95%CI 1.07-1.27)], barium [1.22 (95%CI 1.14-1.30)], cobalt [1.22 (95%CI 1.11-1.34)], cesium [1.35 (95%CI 1.18-1.54)], molybdenum [1.45 (95%CI 1.30-1.62)], antimony [1.18 (95%CI 1.08-1.29)], thallium [1.49 (95%CI 1.33-1.67)], and tungsten [1.23 (95%CI 1.15-1.32)] were significantly associated with MAFLD risk after adjusting for potential covariates. The results for NAFLD were similar to those for MAFLD, except for arsenic, which was insignificantly associated with NAFLD. In mixture analysis, the overall metal mixture was positively associated with MAFLD, NAFLD, and MAFLD components, including obesity/overweight, diabetes, and metabolic dysfunction. In both BKMR and QGC models, thallium, molybdenum, tungsten, and barium mainly contributed to the positive association with MAFLD.
CONCLUSION
Our study indicated that exposure to heavy metals, individually or cumulatively, was positively associated with NAFLD, MAFLD, and MAFLD components, including obesity/overweight, diabetes, and metabolic dysfunction. Additional research is needed to validate these findings in longitudinal settings.
Topics: Adult; Humans; Non-alcoholic Fatty Liver Disease; Molybdenum; Nutrition Surveys; Thallium; Barium; Arsenic; Bayes Theorem; Overweight; Tungsten; Obesity
PubMed: 36950101
DOI: 10.3389/fpubh.2023.1133194 -
Brain and Behavior Mar 2021Thallium poisoning is a rare occurrence. Therefore, thallium poisoning is easily misdiagnosed and is often accompanied by a series of serious sequelae and can even... (Review)
Review
INTRODUCTION
Thallium poisoning is a rare occurrence. Therefore, thallium poisoning is easily misdiagnosed and is often accompanied by a series of serious sequelae and can even result in death in severe cases. Here, we report long-term follow-up of a case of a patient who was poisoned with thallium on two separate occasions.
METHODS
A 43-year-old man was initially misdiagnosed as gastroenteritis, diabetic peripheral neuropathy, and Guillain-Barré Syndrome (GBS) within 21 months. The correct diagnosis was confirmed by blood and urine thallium assays. After Prussian blue treatment, thallium was undetectable in the blood by day 60. Following this investigation, a criminal suspect confessed to two instances of adulterating thallium sulfate in the patient's beverage. A 6-year follow-up was performed after discharge, and a comprehensive literature was review.
RESULTS
We found that the original gastrointestinal symptoms, skin lesions, and hair loss were reversed and had recovered, except for residual neurologic damage, even with long-term rehabilitation.
DISCUSSION
Thallium intoxication may have been initially identified if neurologic symptoms had occurred concurrently with gastrointestinal and cutaneous symptoms. Neurologic damage represented the main sequelae of thallium poisoning in our present case report.
Topics: Adult; Alopecia; Diagnostic Errors; Humans; Male; Thallium
PubMed: 33438838
DOI: 10.1002/brb3.2032 -
Environmental Monitoring and Assessment Nov 2016Thallium is released into the biosphere from both natural and anthropogenic sources. It is generally present in the environment at low levels; however, human activity... (Review)
Review
Thallium is released into the biosphere from both natural and anthropogenic sources. It is generally present in the environment at low levels; however, human activity has greatly increased its content. Atmospheric emission and deposition from industrial sources have resulted in increased concentrations of thallium in the vicinity of mineral smelters and coal-burning facilities. Increased levels of thallium are found in vegetables, fruit and farm animals. Thallium is toxic even at very low concentrations and tends to accumulate in the environment once it enters the food chain. Thallium and thallium-based compounds exhibit higher water solubility compared to other heavy metals. They are therefore also more mobile (e.g. in soil), generally more bioavailable and tend to bioaccumulate in living organisms. The main aim of this review was to summarize the recent data regarding the actual level of thallium content in environmental niches and to elucidate the most significant sources of thallium in the environment. The review also includes an overview of analytical methods, which are commonly applied for determination of thallium in fly ash originating from industrial combustion of coal, in surface and underground waters, in soils and sediments (including soil derived from different parent materials), in plant and animal tissues as well as in human organisms.
Topics: Coal; Coal Ash; Environmental Monitoring; Environmental Pollutants; Humans; Metals, Heavy; Plants; Soil; Thallium
PubMed: 27783348
DOI: 10.1007/s10661-016-5647-y -
International Journal of Environmental... Feb 2023Thallium is widely used in industrial and agricultural development. However, there is still a lack of systematic understanding of its environmental hazards and related... (Review)
Review
Thallium is widely used in industrial and agricultural development. However, there is still a lack of systematic understanding of its environmental hazards and related treatment methods or technologies. Here, we critically assess the environmental behavior of thallium in aqueous systems. In addition, we first discuss the benefits and limitations of the synthetic methods of metal oxide materials that may affect the practicality and scalability of TI removal from water. We then assess the feasibility of different metal oxide materials for TI removal from water by estimating the material properties and contaminant removal mechanisms of four metal oxides (Mn, Fe, Al, and Ti). Next, we discuss the environmental factors that may inhibit the practicality and scalability of Tl removal from water. We conclude by highlighting the materials and processes that could serve as more sustainable alternatives to TI removal with further research and development.
Topics: Thallium; Water Pollutants, Chemical; Oxides; Water; Water Purification; Adsorption
PubMed: 36900837
DOI: 10.3390/ijerph20053829 -
Molecules (Basel, Switzerland) Dec 2021Synthesis, single-crystal X-ray determination diffraction and FT-IR, NMR (H, C, F and Tl), UV-vis, and luminescence spectra characteristics were described for series of...
Synthesis, single-crystal X-ray determination diffraction and FT-IR, NMR (H, C, F and Tl), UV-vis, and luminescence spectra characteristics were described for series of thallium(I) compounds: thallium(I) triflate (Tl(OTf)), 1:1 co-crystals of thallium(I) triflate and tropolone (Htrop), Tl(OTf)·Htrop, as well as simple thallium(I) chelates: Tl(trop) (), Tl(5-metrop) (), Tl(hino) (), with Htrop, 5-methyltropolone (5-meHtrop), 4-isopropyltropolone (hinokitiol, Hhino), respectively, and additionally more complex {Tl@[Tl(hino)]}(OTf) () compound. Comparison of their antimicrobial activity with selected lead(II) and bismuth(III) analogs and free ligands showed that only bismuth(III) complexes demonstrated significant antimicrobial activity, from two- to fivefold larger than the free ligands.
Topics: Anti-Infective Agents; Bismuth; Chemistry Techniques, Synthetic; Lead; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Spectrum Analysis; Structure-Activity Relationship; Thallium; Tropolone
PubMed: 35011415
DOI: 10.3390/molecules27010183 -
Environmental Pollution (Barking, Essex... Jan 2022Thallium, a highly toxic heavy metal and priority pollutant, has been widely reported to cause neurodevelopmental toxicity in animals. However, accessible...
Thallium, a highly toxic heavy metal and priority pollutant, has been widely reported to cause neurodevelopmental toxicity in animals. However, accessible epidemiological studies concerning the neurodevelopmental toxicity of early-life thallium exposure in humans are limited. In a prospective birth cohort including 2164 mother-child pairs, we explored the effect of prenatal serum thallium exposure on cognitive development among preschool-aged children born in Ma'anshan, Anhui, China. Serum thallium concentrations were measured in the first trimester, second trimester, third trimester, and cord blood by inductively coupled plasma mass spectrometry (ICP-MS). Child cognitive development was appraised by the Chinese version of the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition (WPPSI-IV) at 4.5 years old. Multiple informants generalized estimating equations (GEEs) were fit to jointly estimate the association between the four repeated measurements of thallium concentrations and the preschool-aged children's cognitive test scores. After adjusting for potential confounders, the visual spatial index (VSI) was 1.45 points lower in the highest tertile of serum thallium during the first trimester than in the lowest tertile (p for trend = 0.04). Moreover, children in the highest tertile of serum thallium during the third trimester had a significantly lower full-scale intelligence quotient (FSIQ) (β = -1.51, 95% CI: -2.68, -0.35), VSI (β = -1.79, 95% CI: -3.16, -0.42), fluid reasoning index (FRI) (β = -1.41, 95% CI: -2.73, -0.10), and processing speed index (PSI) (β = -1.47, 95% CI: -2.71, -0.24) scores than the children in the lowest tertile. When performing stratified analysis by child sex, the associations of first- and third-trimester thallium concentrations with cognitive test scores were more prominent in boys than in girls. Our findings revealed that maternal serum thallium exposure during the first and third trimesters, but not other periods, had detrimental effects on preschoolers' cognitive development, and these effects showed sex differences.
Topics: Birth Cohort; Child Development; Child, Preschool; China; Cognition; Female; Humans; Male; Maternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Thallium
PubMed: 34801620
DOI: 10.1016/j.envpol.2021.118545 -
Environment International Apr 2022Thallium is a highly poisonous heavy metal. Since Tl pollution control has been neglected worldwide until the present, countless Tl pollutants have been discharged into... (Review)
Review
Thallium is a highly poisonous heavy metal. Since Tl pollution control has been neglected worldwide until the present, countless Tl pollutants have been discharged into the environment, endangering the safety of drinking water, farmland soil, and food chain, and eventually posing a great threat to human health. However, the source, occurrence, pathway and fate of Tl in the environment remains understudied. As Tl in non-contaminated systems and from anthropogenic origin exhibits generally different isotopic signatures, which can provide fingerprint information and a novel way for tracing the anthropogenic Tl sources and understanding the environmental processes. This review summarizes: (i) the state-of-the-art development in highly-precise determination analytical method of Tl isotopic compositions, (ii) Tl isotopic fractionation induced by the low-temperature surface biogeochemical process, (iii) Tl isotopic signature of pollutants derived from anthropogenic activities and isotopic fractionation mechanism of Tl related to the high-temperature industrial activities, and (iv) application of Tl isotopic composition as a new tracer emerging tracer for source apportionment of Tl pollution. Finally, the limitations and possible future research about Tl isotopic application in environmental contamination is also proposed: (1) Tl fractionation mechanism in different environmental geochemistry processes and industrial activities should be further probed comprehensively; (2) Tl isotopes for source apportionment should be further applied in other different high Tl-contaminated scenarios (e.g., agricultural systems, water/sediment, and atmosphere).
Topics: Agriculture; Environmental Pollutants; Environmental Pollution; Humans; Isotopes; Thallium
PubMed: 35219934
DOI: 10.1016/j.envint.2022.107148 -
Environment International May 2019Thallium (Tl) is a typical toxic metal, which poses a great threat to human health through drinking water and the food chain (biomagnification). China has rich... (Review)
Review
Thallium (Tl) is a typical toxic metal, which poses a great threat to human health through drinking water and the food chain (biomagnification). China has rich Tl-bearing mineral resources, which have been extensively explored and utilized, leading to release of large amounts of Tl into the environment. However, research on Tl pollution and removal techniques is relatively limited, because Tl has not been listed within the scope of environmental monitoring in China for several decades. This paper reviewed Tl pollution in wastewater arising from various industries in China, as well as the latest available methods for treating Tl-containing industrial wastewater, in order to give an outlook on effective technologies for controlling Tl pollution. Conventional physical and chemical treatment technologies are efficient at removing trace amounts of Tl, but it proved to be difficult to achieve the stringent environmental standard (≤0.1-5 μg/L) cost-effectively. Adsorption by using newly developed nanomaterials, and metal oxide modified polymer materials and microbial fuel cells are highly promising and expected to become next-generation technologies for remediation of Tl pollution. With the potential for greater Tl contamination in the environment under accelerated growth of industrialization, researches based on lab-scale implementation of such promising treatment technologies should be further expanded to pilot and industrial scale, ensuring environmental protection and the safety of drinking water for sustainable development. Comprehensive insights into experiences of Tl pollution in China and in-depth perspectives on new frontier technologies of Tl removal from wastewaters will also benefit other nations/regions worldwide, which are susceptible to high exposure to Tl likewise.
Topics: China; Environmental Monitoring; Environmental Restoration and Remediation; Thallium; Wastewater; Water Pollutants, Chemical; Water Pollution, Chemical
PubMed: 30884277
DOI: 10.1016/j.envint.2019.01.076 -
Arhiv Za Higijenu Rada I Toksikologiju Mar 2010Thallium is a naturally occurring trace element, widely distributed in the earth's crust, but at very low concentrations. It does not have a known biological use and... (Review)
Review
Thallium is a naturally occurring trace element, widely distributed in the earth's crust, but at very low concentrations. It does not have a known biological use and does not appear to be an essential element for life. It has been considered one of the most toxic heavy metals.Occasionally, there are reports on thallium poisoning as results of suicide or murder attempt or accident. The main threat to humans is through occupational exposure, environmental contamination, and accumulation in food, mainly in vegetables grown on contaminated soil. Increasing use in emerging new technologies and demanding high-tech industry constantly raise concern about exposure risk to all living organisms. Thallium is considered a cumulative poison that can cause adverse health effects and degenerative changes in many organs. The effects are the most severe in the nervous system. The exact mechanism of thallium toxicity still remains unknown, although impaired glutathione metabolism, oxidative stress, and disruption of potassium-regulated homeostasis may play a role. The lack of data about mutagenic, carcinogenic, or teratogenic effects of thallium compounds in humans calls for further research.
Topics: Humans; Thallium
PubMed: 20338874
DOI: 10.2478/10004-1254-61-2010-1976 -
Ecotoxicology and Environmental Safety May 2024Thallium (Tl) is a non-essential metal mobilized through industrial processes which can lead to it entering the environment and exerting toxic effects. Plants are...
Thallium (Tl) is a non-essential metal mobilized through industrial processes which can lead to it entering the environment and exerting toxic effects. Plants are fundamental components of all ecosystems. Therefore, understanding the impact of Tl on plant growth and development is of great importance for assessing the potential environmental risks of Tl. Here, the responses of Arabidopsis thaliana to Tl were elucidated using physiological, genetic, and transcriptome analyses. Thallium can be absorbed by plant roots and translocated to the aerial parts, accumulating at comparable concentrations throughout plant parts. Genetic evidence supported the regulation of Tl uptake and movement by different molecular compartments within plants. Thallium primarily caused growth inhibition, oxidative stress, leaf chlorosis, and the impairment of K homeostasis. The disturbance of redox balance toward oxidative stress was supported by significant differences in the expression of genes involved in oxidative stress and antioxidant defense under Tl exposure. Reduced GSH levels in cad2-1 mutant rendered plants highly sensitive to Tl, suggesting that GSH has a prominent role in alleviating Tl-triggered oxidative responses. Thallium down-regulation of the expression of LCHII-related genes is believed to be responsible for leaf chlorosis. These findings illuminate some of the mechanisms underlying Tl toxicity at the physiological and molecular levels in plants with an eye toward the future environment management of this heavy metal.
Topics: Arabidopsis; Thallium; Oxidative Stress; Plant Roots; Gene Expression Regulation, Plant; Plant Leaves; Soil Pollutants
PubMed: 38599154
DOI: 10.1016/j.ecoenv.2024.116290