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Transplant International : Official... 2024
Topics: Humans; Liver Transplantation; Transplants; Perfusion; Organ Preservation; Graft Survival; Liver
PubMed: 38544563
DOI: 10.3389/ti.2024.12853 -
American Journal of Transplantation :... Feb 2022COVID-19 vaccination mandates: A patient’s view from the transplant trenches (see Kates et al. and Hippen, pages 371 and 381).
COVID-19 vaccination mandates: A patient’s view from the transplant trenches (see Kates et al. and Hippen, pages 371 and 381).
Topics: Humans; Organ Transplantation; Transplant Recipients; Transplants; Vaccines
PubMed: 34860466
DOI: 10.1111/ajt.16908 -
Xenotransplantation May 2018Accommodation refers to a condition in which a transplant (or any tissue) appears to resist immune-mediated injury and loss of function. Accommodation was discovered and... (Review)
Review
Accommodation refers to a condition in which a transplant (or any tissue) appears to resist immune-mediated injury and loss of function. Accommodation was discovered and has been explored most thoroughly in ABO-incompatible kidney transplantation. In this setting, kidney transplants bearing blood group A or B antigens often are found to function normally in recipients who lack and hence produce antibodies directed against the corresponding antigens. Whether accommodation is owed to changes in anti-blood group antibodies, changes in antigen or a change in the response of the transplant to antibody binding are critically reviewed and a new working model that allows for the kinetics of development of accommodation is put forth. Regardless of how accommodation develops, observations on the fate of ABO-incompatible transplants offer lessons applicable more broadly in transplantation and in other fields.
Topics: Animals; Graft Rejection; Graft Survival; Humans; Kidney Transplantation; Transplantation, Heterologous; Transplantation, Homologous; Transplants
PubMed: 29913044
DOI: 10.1111/xen.12418 -
Medicina (Kaunas, Lithuania) May 2021Since its first detection in 1948, donor-derived cell-free DNA (dd-cfDNA) has been employed for a myriad of indications in various medical specialties. It has had a... (Review)
Review
Since its first detection in 1948, donor-derived cell-free DNA (dd-cfDNA) has been employed for a myriad of indications in various medical specialties. It has had a far-reaching impact in solid organ transplantation, with the most widespread utilization in kidney transplantation for the surveillance and detection of allograft rejection. The purpose of this review is to track the arc of this revolutionary test-from origins to current use-along with examining challenges and future prospects though the lens of transplant nephrology.
Topics: Cell-Free Nucleic Acids; Graft Rejection; Humans; Kidney Transplantation; Tissue Donors; Transplants
PubMed: 34065914
DOI: 10.3390/medicina57050482 -
Cold Spring Harbor Perspectives in... Mar 2014Vascularized composite allotransplantation (VCA) is a novel therapeutic option for treatment of patients suffering from limb loss or severe facial disfigurement. To... (Review)
Review
Vascularized composite allotransplantation (VCA) is a novel therapeutic option for treatment of patients suffering from limb loss or severe facial disfigurement. To date, 72 hand and 19 facial transplantations have been performed worldwide. VCA in hand and facial transplantation is a complex procedure requiring a multidisciplinary team approach and extensive surgical planning. Despite good functional outcome, courses after hand and facial transplantation have been complicated by skin rejection. Long-term immunosuppression remains a necessity in VCA for allograft survival. To widen the scope of these quality-of-life-improving procedures, minimization of immunosuppression to limit risks and side effects is needed.
Topics: Composite Tissue Allografts; Facial Transplantation; Graft Rejection; Hand Transplantation; Humans; Immunosuppression Therapy; Motor Neurons; Patient Satisfaction; Transplantation Immunology; Transplantation, Homologous; Treatment Outcome
PubMed: 24478387
DOI: 10.1101/cshperspect.a015651 -
Transplant International : Official... Jul 2018More than thirty-five facial allograft transplantations (FAT) have been reported worldwide since the pioneering case performed in France in the year 2005. FAT has... (Review)
Review
More than thirty-five facial allograft transplantations (FAT) have been reported worldwide since the pioneering case performed in France in the year 2005. FAT has received tremendous interest by the medical field and the general public while gaining strong support from multiple disciplines as a solution for reconstructing complex facial defects not amenable/responsive to conventional methods. FAT has expanded the frontiers of reconstructive microsurgery, immunology and transplantation, and established its place in the cross section of multiple disciplines. The procedure introduces complex scientific, ethical, and societal issues. Patients and physicians are called to deal with a variety of-sometimes everlasting-challenges, such as immunosuppression management and psychosocial hurdles. This review reflects on the surgical and scientific advancements in FAT and milestones reached in the last 12 years. It aims to encourage active discussion regarding the current practices and techniques used in FAT and suggest future directions that may allow transitioning into the next phase of FAT, which we describe as safe, reliable, and accessible standard operation for selected patients.
Topics: Allografts; Facial Transplantation; Humans; Patient Selection; Transplantation Immunology; Treatment Outcome
PubMed: 29421860
DOI: 10.1111/tri.13130 -
Annual Review of Animal Biosciences Feb 2024End-stage organ failure can result from various preexisting conditions and occurs in patients of all ages, and organ transplantation remains its only treatment. In... (Review)
Review
End-stage organ failure can result from various preexisting conditions and occurs in patients of all ages, and organ transplantation remains its only treatment. In recent years, extensive research has been done to explore the possibility of transplanting animal organs into humans, a process referred to as xenotransplantation. Due to their matching organ sizes and other anatomical and physiological similarities with humans, pigs are the preferred organ donor species. Organ rejection due to host immune response and possible interspecies infectious pathogen transmission have been the biggest hurdles to xenotransplantation's success. Use of genetically engineered pigs as tissue and organ donors for xenotransplantation has helped to address these hurdles. Although several preclinical trials have been conducted in nonhuman primates, some barriers still exist and demand further efforts. This review focuses on the recent advances and remaining challenges in organ and tissue xenotransplantation.
Topics: Animals; Humans; Swine; Transplantation, Heterologous; Organ Transplantation; Genetic Engineering; Transplants
PubMed: 37906838
DOI: 10.1146/annurev-animal-021122-102606 -
International Journal of Surgery... Oct 2020A dilemma of graft selection between right or left livers occurs during the planning of living-donor liver transplantation (LDLT) as well as splitting a whole liver...
A dilemma of graft selection between right or left livers occurs during the planning of living-donor liver transplantation (LDLT) as well as splitting a whole liver graft into full right/full left grafts in deceased-donor liver transplantation. The right liver's relation to the whole liver could be considered as the trunk of a tree; it has a larger volume, the main axis of bile ducts, and the inferior vena cava mainly belongs to the right liver. Therefore, it was considered as the standard graft in LDLTs. Whether to procure the middle hepatic vein (MHV) with a right liver graft or to leave it attached to the left-liver remnant largely depends on the transplant institute. Recently, most transplant institutes tend to leave the MHV with the left liver for the sake of donor safety. Unlike hepatectomy for liver tumors, it is vital to preserve inflow and outflow for both the resected as well as the remaining livers. While procuring any graft type, the most important is to procure a liver graft with reconstructable portal veins, hepatic arteries, hepatic veins, and bile ducts, which should be well preoperatively planned using 3D-computed tomography with considerations given to graft volume and potential congestion areas.
Topics: Adult; Female; Hepatectomy; Hepatic Artery; Hepatic Veins; Humans; Liver; Liver Transplantation; Living Donors; Male; Middle Aged; Portal Vein; Tissue and Organ Harvesting; Transplants; Vena Cava, Inferior
PubMed: 32619620
DOI: 10.1016/j.ijsu.2020.06.022 -
American Journal of Transplantation :... Dec 2018
Topics: Hematopoietic Stem Cell Transplantation; Humans; Mitochondria; Tissue and Organ Procurement; Transplants
PubMed: 30476365
DOI: 10.1111/ajt.15157 -
Ugeskrift For Laeger Apr 2023Since the first kidney transplant was conducted in Denmark in 1964, almost 10,000 transplants have been performed. Graft survival has improved over the past two decades... (Review)
Review
Since the first kidney transplant was conducted in Denmark in 1964, almost 10,000 transplants have been performed. Graft survival has improved over the past two decades despite the increase in age and comorbidities in both donors and recipients, but organ shortage remains a challenge. The focus of this review is to describe the challenges in kidney transplant and highlight the progress achieved in solving these challenges.
Topics: Humans; Kidney Transplantation; Living Donors; Tissue Donors; Tissue and Organ Procurement; Transplants; Denmark; Registries
PubMed: 37057695
DOI: No ID Found