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Journal Francais D'ophtalmologie Dec 2022
Topics: Humans; Triamcinolone; Fovea Centralis; Triamcinolone Acetonide
PubMed: 36307346
DOI: 10.1016/j.jfo.2022.06.005 -
Postgraduate Medical Journal Jan 1960
Topics: Humans; Triamcinolone
PubMed: 13850669
DOI: 10.1136/pgmj.36.411.23 -
The Annals of Pharmacotherapy Oct 2010To review published literature regarding the safety and effectiveness of intrapericardial triamcinolone for the treatment of autoreactive pericarditis. (Review)
Review
OBJECTIVE
To review published literature regarding the safety and effectiveness of intrapericardial triamcinolone for the treatment of autoreactive pericarditis.
DATA SOURCES
Searches of MEDLINE (1966-June 2010) and Cochrane Database (1993-June 2010) were conducted. Limits included articles published in English reporting on human subjects. Additional data were identified through bibliographic reviews.
STUDY SELECTION AND DATA EXTRACTION
All English-language articles identified from the data sources were evaluated. Trials, studies, and case reports were eligible for inclusion if they evaluated the safety and/or efficacy of intrapericardial triamcinolone for the management of autoreactive pericarditis.
DATA SYNTHESIS
Systemic corticosteroids offer an effective treatment option for autoreactive pericarditis; however, their use is limited by adverse effects and they are an independent risk factor for pericarditis recurrence. One case series and 3 open-label trials evaluating intrapericardial triamcinolone for the management of autoreactive pericarditis are reviewed. Included studies were limited by small sample sizes (N = 2-84), lack of control groups, short durations of follow-up (24 h to 12 mo), use of adjuvant agents, omission of patient demographic data, subjective report of symptom relief, and lack of consistent dose of intrapericardial triamcinolone. Despite these limitations, the data suggest symptom resolution and reduced pericarditis recurrence with administration of intrapericardial triamcinolone to patients with autoreactive pericarditis.
CONCLUSIONS
There is growing evidence that intrapericardial triamcinolone is safe and effective for the management of autoreactive pericarditis. The appropriate regimen (dose and duration of treatment), adverse effect profile, and specific therapeutic role require further investigation.
Topics: Anti-Inflammatory Agents; Humans; Injections, Intralesional; Pericarditis; Triamcinolone
PubMed: 20736423
DOI: 10.1345/aph.1P294 -
Orvosi Hetilap Dec 1959
Topics: Triamcinolone
PubMed: 14406131
DOI: No ID Found -
Current Diabetes Reviews Feb 2006Diabetic macular edema is one of the leading causes of visual loss in first world countries and the first cause in diabetic retinopathy. The Early Treatment Diabetic... (Review)
Review
Diabetic macular edema is one of the leading causes of visual loss in first world countries and the first cause in diabetic retinopathy. The Early Treatment Diabetic Retinopathy Study showed a significant benefit in using focal laser photocoagulation for the treatment of macular edema, more specifically defined as clinically significant macular edema. Nevertheless, progressive visual loss is found in the 26% of patients with diabetic macular edema treated with photocoagulation. The failure of laser treatment and the destructive nature of the therapy has forced researchers to pursue new alternatives including vitrectomy with or without internal limiting membrane peels, the use of proteinkinase C inhibitors, intravitreal injections of antibodies that inhibit the vascular endothelial growth factor, somatostatin analog, or the intravitreal injection with corticosteroids. Triamcinolone acetonide is glucocoticosteroid with antiangiogenic and antiedematous properties. Publications evaluating the safety and efficacy of intravitreal injection of triamcinolone in the treatment of diabetic macular edema show varying outcomes with respect to the increases of visual acuity and decreases in foveal thickness. Despite this, intravitreal triamcinolone is a treatment that has evolved quickly and is considered increasingly useful.
Topics: Anti-Inflammatory Agents; Diabetic Retinopathy; Half-Life; Humans; Laser Coagulation; Macular Edema; Triamcinolone; Vitreous Body
PubMed: 18220620
DOI: 10.2174/157339906775473572 -
Journal of the American Academy of... May 2006
Topics: Administration, Oral; Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Child; Humans; Nephrotic Syndrome; Patient Compliance; Triamcinolone
PubMed: 16635667
DOI: 10.1016/j.jaad.2006.01.027 -
The Western Journal of Medicine Sep 1980
Topics: Humans; Injections; Keloid; Triamcinolone; Triamcinolone Acetonide
PubMed: 7415179
DOI: No ID Found -
The American Journal of Sports Medicine Sep 2023Intra-articular corticosteroid or hyaluronic acid (HA) is commonly prescribed for frozen shoulder. However, few studies have investigated histological and molecular...
BACKGROUND
Intra-articular corticosteroid or hyaluronic acid (HA) is commonly prescribed for frozen shoulder. However, few studies have investigated histological and molecular changes after injection.
PURPOSE
To compare the effectiveness of intra-articular injections of triamcinolone and HA in a frozen shoulder rat model and verify a greater effect of triamcinolone in passive shoulder abduction compared with HA.
STUDY DESIGN
Controlled laboratory study.
METHODS
Twenty male Sprague-Dawley rats were randomly allocated into 4 groups (n = 5 in each): control group, which did not receive cast immobilization or injection, and 3 experimental groups, which received 3 weeks of unilateral shoulder immobilization followed by intra-articular injections (normal saline, triamcinolone, or HA) at the immobilized shoulder. Passive shoulder abduction angle, histological and immunohistochemical staining, and Western blotting results were assessed 2 weeks after injection. The intensity and extent of staining were converted to semiquantitative scores for further analysis.
RESULTS
Shoulder abduction angles before sacrifice were 153.0°± 2.7° (control group), 107.0°± 5.7° (saline group), 139.0°± 9.6° (triamcinoline group), and 110.0°± 10.6° (HA group), showing significant differences between control and saline groups, control and HA groups, saline and triamcinoline groups, and triamcinoline and HA groups ( < .001) but not between control and triamcinoline groups ( = .053). Histologic evaluation revealed an increase in synovial folds and thickening of the capsular membrane in the saline and HA groups; this change was not evident in the triamcinolone group. A comparison of semiquantitative scores revealed greater expression levels of proteins involved in fibrosis and angiogenesis in the saline and HA groups compared with the control and triamcinolone groups. In Western blotting, the expression of inflammatory cytokines and the receptor for advanced glycation end products was significantly lower in the triamcinolone and HA groups than in the saline group.
CONCLUSION
Triamcinolone injection was more effective than normal saline or HA injection in improving range of motion and reversing fibrotic and angiogenic features of frozen shoulder. Both triamcinolone and HA injections elicited anti-inflammatory effects.
CLINICAL RELEVANCE
The antifibrotic and antiangiogenic properties of triamcinolone and the anti-inflammatory properties of both triamcinolone and HA should be considered when performing injections in clinical settings.
Topics: Male; Animals; Rats; Triamcinolone; Hyaluronic Acid; Saline Solution; Rats, Sprague-Dawley; Bursitis; Anti-Inflammatory Agents; Injections, Intra-Articular; Range of Motion, Articular; Treatment Outcome
PubMed: 37551671
DOI: 10.1177/03635465231188524 -
Annals of Allergy, Asthma & Immunology... Feb 2003The primary objective was to report a case of triamcinolone-induced anaphylaxis and review the proposed mechanisms of corticosteroid-associated hypersensitivity... (Review)
Review
OBJECTIVE
The primary objective was to report a case of triamcinolone-induced anaphylaxis and review the proposed mechanisms of corticosteroid-associated hypersensitivity reactions.
DATA SOURCES
Articles in French and English were identified from references in relevant articles and from articles retrieved from the PubMed web site. Indexing terms consisted of corticosteroids in conjunction with the terms anaphylaxis, hypersensitivity reactions, asthma, urticaria, and angioedema.
STUDY SELECTION
We reviewed all articles that described a case or cases of allergic-type reaction in association with corticosteroid use and for which we could obtain the full text of the article (>95%).
RESULTS
We report an anaphylactic reaction occurring after an intraarticular injection of triamcinolone in a 75-year-old man who had positive prick skin tests to triamcinolone and negative tests to lidocaine, methylprednisolone, and hydrocortisone.
CONCLUSIONS
To date, there have been approximately 100 published reports of immediate hypersensitivity reactions occurring after oral and parenteral administration of corticosteroids. Both immunologic and nonimmunologic mechanisms are proposed, but there is no definitive evidence in favor of either hypothesis. Our patient demonstrated positive prick skin tests to triamcinolone in a dose-response manner, suggesting the likelihood that an immunoglobulin E-mediated hypersensitivity mechanism may play a role.
Topics: Adolescent; Adult; Aged; Anaphylaxis; Anti-Inflammatory Agents; Female; Humans; Injections, Intra-Articular; Male; Middle Aged; Skin Tests; Triamcinolone
PubMed: 12602676
DOI: 10.1016/S1081-1206(10)62151-5 -
Clinical Hemorheology and... 2023Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures....
BACKGROUND
Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects.
OBJECTIVE
The main objective of this study was to gain further information about the impact of the corticosteroid triamcinolone on cell migration in abdominoplasty patients.
METHODS
An in-vitro scratch assay wound healing model was applied to observe cell migration of fibroblasts cultured with nutrient medium containing human seroma aspirate±triamcinolone.
RESULTS
There were no significant differences regarding cell migration when fibroblasts were incubated with triamcinolone + seroma containing culture medium compared to seroma containing culture medium without triamcinolone.
CONCLUSIONS
The performed in-vitro study suggests that triamcinolone does not decelerate fibroblast cell migration which is considered as a surrogate of wound healing.
Topics: Humans; Triamcinolone; Seroma; Cell Movement; Adrenal Cortex Hormones; Fibroblasts; Abdominoplasty
PubMed: 36502314
DOI: 10.3233/CH-229106