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Microbial Genomics Nov 2021The medically relevant species complex has a variety of phenotypic presentations but shows relatively little genetic differences. Conventional barcodes, such as the...
The medically relevant species complex has a variety of phenotypic presentations but shows relatively little genetic differences. Conventional barcodes, such as the internal transcribed spacer (ITS) region or the beta-tubulin gene, are not able to completely resolve the relationships between these closely related taxa. , and are currently accepted as separate species. However, the status of certain variants, including the morphotypes and and the morphotype , remains to be deciphered. We conducted the first phylogenomic analysis of the species complex by studying 3105 core genes of 18 new strains from the BCCM/IHEM culture collection and nine publicly available genomes. Our analyses revealed a highly resolved phylogenomic tree with six separate clades. , and were confirmed in their status of species. The morphotypes and all grouped in their own respective clade with high support, suggesting that these morphotypes should be reinstituted to the species-level. Robinson-Foulds distance analyses showed that a combination of two markers (a ubiquitin-protein transferase and a MYB DNA-binding domain-containing protein) can mirror the phylogeny obtained using genomic data, and thus represent potential new markers to accurately distinguish the species belonging to the complex.
Topics: Arthrodermataceae; Phylogeny; Trichophyton
PubMed: 34730487
DOI: 10.1099/mgen.0.000707 -
Journal of Clinical Microbiology Sep 2000The validity of taxa around Trichophyton rubrum was evaluated by a combination of phenetic and molecular methods. Morphological and physiological features were compared...
The validity of taxa around Trichophyton rubrum was evaluated by a combination of phenetic and molecular methods. Morphological and physiological features were compared to results of sequencing of the internal transcribed spacer region of the ribosomal operon, PCR fingerprinting, and amplified fragment length polymorphism analysis. The 15 species and varieties investigated (Trichophyton circonvolutum, Trichophyton fischeri, Trichophyton fluviomuniense, Trichophyton glabrum, Trichophyton gourvilii, Trichophyton kanei, Trichophyton kuryangei, Trichophyton megninii, Trichophyton pedis, Trichophyton raubitschekii, Trichophyton rodhaini, Trichophyton rubrum var. nigricans, Trichophyton soudanense, Trichophyton violaceum var. indicum, and Trichophyton yaoundei) were reclassified or synonymized as T. rubrum or T. violaceum.
Topics: Adult; Child; DNA Fingerprinting; DNA, Fungal; Humans; Phylogeny; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA; Tinea; Trichophyton
PubMed: 10970379
DOI: 10.1128/JCM.38.9.3329-3336.2000 -
The Journal of Investigative Dermatology Jul 1963
Topics: Africa; Arthrodermataceae; Black People; Child; Culture Media; Humans; Research; Statistics as Topic; Tinea Capitis; Trichophyton; White People
PubMed: 14043005
DOI: No ID Found