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New Microbes and New Infections Mar 2018is an aerobic, Gram-positive and nonmotile bacterium. It was first isolated in 1941 from the mycetoma and ovaries of the bedbug. The primary strains were named and... (Review)
Review
is an aerobic, Gram-positive and nonmotile bacterium. It was first isolated in 1941 from the mycetoma and ovaries of the bedbug. The primary strains were named and and are different from the Collins , 1988 classification of the new genus. Human infections with species are rare because the species is a kind of saprophyte bacterium; however, most information regarding this species comes from case reports. Molecular markers for the identification include sequencing of 16S rRNA, and genes. Given the lack of information on the treatment of infections, a combination of various antibiotic agents is recommended.
PubMed: 29556401
DOI: 10.1016/j.nmni.2017.10.002 -
The Lancet. Infectious Diseases Jul 2022
Topics: Actinomycetales; Diagnostic Errors; Humans; Pneumonia; Tuberculosis, Pulmonary
PubMed: 35752177
DOI: 10.1016/S1473-3099(22)00134-7 -
Emerging Infectious Diseases Jul 2022Unidentified Mycobacterium species are sometimes detected in respiratory specimens. We identified a novel Tsukamurella species (Tsukamurella sp. TY48, RIMD 2001001, CIP...
Unidentified Mycobacterium species are sometimes detected in respiratory specimens. We identified a novel Tsukamurella species (Tsukamurella sp. TY48, RIMD 2001001, CIP 111916), Tsukamurella toyonakaense, from a patient given a misdiagnosis of nontuberculous mycobacterial pulmonary disease caused by unidentified mycobacteria. Genomic identification of this Tsukamurella species helped clarify its clinical characteristics and epidemiology.
Topics: Humans; Lung Diseases; Mycobacterium; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria
PubMed: 35731181
DOI: 10.3201/eid2807.212320 -
World Journal of Clinical Cases Aug 2022species are obligate aerobic, gram-positive, weak acid-fast, nonmotile bacilli. They are found in various environments, such as soil, water, sludge, and petroleum... (Review)
Review
species are obligate aerobic, gram-positive, weak acid-fast, nonmotile bacilli. They are found in various environments, such as soil, water, sludge, and petroleum reservoir wastewater, and belong to the order . In 2016, there was a reclassification of species within the genus , merging the species () and . species are clinically considered to be a rare opportunistic pathogen, because most reported cases have been related to bacteremia and intravascular prosthetic devices and immunosuppression. To date, it has been isolated only from human specimens, and has always been associated with clinical disease; human infections are very rare. Reported infections have included pneumonia, brain abscesses, catheter-related bloodstream infections, ocular infections, bacteremia, and sepsis presenting with septic pulmonary emboli in patients who are immunocompromised. To date, there is no commercially available test for identification. On the other hand, sequence-based identification, including matrix-assisted laser desorption ionization time-of-flight mass spectrometry, is an alternative method for identifying clinical isolates that are either slow growers or difficult to identify through biochemical profiling. The golden standards for diagnosis and optimal management still remain to be determined. However, newer molecular biological techniques can provide accurate identification, and contribute to the appropriate selection of definitive therapy for infections caused by this organism. Combinations of several antimicrobial agents have been proposed for treatment, though the length of treatment for infections has yet to be determined, and should be individualized according to clinical response. Immunocompromised patients often experience severe cases due to infection, and life-threatening events associated with dissemination and/or failure of source control have occurred. Favorable prognoses can be achieved through earlier identification of the cause of infection, as well as successful management, including appropriate antibiotic therapy together with source control. Further analyses of similar cases are required to establish the most adequate diagnostic methods and treatment regimens for infections.
PubMed: 36157836
DOI: 10.12998/wjcc.v10.i24.8443 -
Canadian Journal of Ophthalmology.... Oct 2021
Topics: Actinomycetales; Humans; Keratitis; United States
PubMed: 33839066
DOI: 10.1016/j.jcjo.2021.03.005 -
Postgraduate Medicine Aug 2017This report describes a case of Tsukamurella pneumonia in a 24-year-old immunocompetent woman. The patient was diagnosed as having pulmonary tuberculosis and was treated... (Review)
Review
This report describes a case of Tsukamurella pneumonia in a 24-year-old immunocompetent woman. The patient was diagnosed as having pulmonary tuberculosis and was treated for nearly 9 months. The correct diagnosis was suspected only when the results of mycobacteria nucleic acid amplification tests on cultural colonies were negative. Tsukamurella was identified from the patient's sputum and bronchoalveolar lavage fluid by using 16S rRNA sequence analysis. Here, the clinical presentation, diagnosis, and treatment strategies of Tsukamurella pneumonia are discussed, along with a literature review. Tsukamurella pneumonia may be highly underdiagnosed owing to its similarity with pulmonary tuberculosis and the habitual thinking of doctors in countries with a high tuberculosis burden. Tsukamurella should be carefully considered in the etiology of tuberculosis-like lung diseases.
Topics: Actinomycetales; Actinomycetales Infections; Bronchoalveolar Lavage Fluid; Community-Acquired Infections; Diagnosis, Differential; Female; Humans; Microbial Sensitivity Tests; RNA, Ribosomal, 16S; Sputum; Tomography, X-Ray Computed; Tuberculosis, Pulmonary; Young Adult
PubMed: 28628338
DOI: 10.1080/00325481.2017.1344513 -
Diagnostic Microbiology and Infectious... Jul 2020Tsukamurella species are Gram-positive bacilli related to aerobic Actinomyces. Originally reported from the environment, Tsukamurella species have also been described in... (Review)
Review
Catheter-related bloodstream infection due to Tsukamurella pulmonis identified by MALDI-TOF spectrometry, 16S rRNA gene sequencing, and secA1 gene sequencing in an immunocompromised child: a case report and literature review.
Tsukamurella species are Gram-positive bacilli related to aerobic Actinomyces. Originally reported from the environment, Tsukamurella species have also been described in human infections, especially in bacteremia. A literature review analysis revealed that Tsukamurella spp. are often initially considered as contaminant microorganisms, especially due to bacterial identification issues. Here, we report a catheter-related bloodstream infection in an immunocompromised child caused by Tsukamurella pulmonis. Matrix-Assisted Laser Desorption/Ionization-Time Of Flight (MALDI-TOF) mass spectrometry allowed rapid genus-level identification and contributed to better patient care. However, accurate species-level identification required 16S rRNA gene sequencing and secA1 gene sequencing. Considering the increased number of Tsukamurella infections, the implementation of new Tsukamurella species in MALDI-TOF databases is required to be more discriminant.
Topics: Actinobacteria; Anti-Bacterial Agents; Bacteremia; Bacterial Proteins; Catheter-Related Infections; Central Venous Catheters; DNA, Bacterial; Female; Humans; Immunocompromised Host; Infant; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Treatment Outcome
PubMed: 32312485
DOI: 10.1016/j.diagmicrobio.2020.115052 -
IDCases 2022We report a case of catheter-related bloodstream infection by , identified using 16S rRNA gene sequencing, in a patient with arterial hypertension for 20 years and...
We report a case of catheter-related bloodstream infection by , identified using 16S rRNA gene sequencing, in a patient with arterial hypertension for 20 years and chronic kidney disease in hemodialysis since 08/07/2019. To our knowledge, this is the first case of in Ecuador.
PubMed: 35433266
DOI: 10.1016/j.idcr.2022.e01494 -
Enfermedades Infecciosas Y... Oct 2021
Topics: Actinobacteria; Humans; Peritoneal Dialysis; Peritonitis
PubMed: 34620478
DOI: 10.1016/j.eimce.2020.10.010 -
IDCases 2022
PubMed: 35145860
DOI: 10.1016/j.idcr.2022.e01419