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The British Chemical Digest Nov 1947
Topics: Tubocurarine
PubMed: 18915697
DOI: No ID Found -
Proceedings of the Royal Society of... Aug 1948
Topics: Tubocurarine
PubMed: 18877134
DOI: No ID Found -
Lancet (London, England) Nov 1947
Topics: Tetanus; Tetanus Toxoid; Tubocurarine
PubMed: 20340986
DOI: 10.1016/s0140-6736(47)90838-6 -
Anaesthesia and Intensive Care Aug 2005
Topics: Anesthesia; Curare; History, 20th Century; Humans; Intubation, Intratracheal; Neuromuscular Nondepolarizing Agents; North America; Tubocurarine; United Kingdom
PubMed: 16119481
DOI: 10.1177/0310057X0503300401 -
British Journal of Anaesthesia Jul 1976Tubocurarine, given as a single bolus, may be used safely for neuromuscular blockade in the neonate. The recommended dose is 250 mug/kg at birth, increasing to 500...
Tubocurarine, given as a single bolus, may be used safely for neuromuscular blockade in the neonate. The recommended dose is 250 mug/kg at birth, increasing to 500 mug/kg at 28 days of age. This dose should be reduced in the event of prematurity, acidosis or hypothermia, or when certain antibiotics or inhalation anaesthetic agents are present in the tissues. A single dose as described has a duration of approximately 1 h and it is only after this time that satisfactory antagonism can be obtained. The potency of pancuronium when compared with tubocurarine in the study is 6:1, from birth to 28 days.
Topics: Age Factors; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Pancuronium; Tubocurarine
PubMed: 1016646
DOI: 10.1093/bja/48.7.687 -
Anesthesiology 1965
Topics: Pharmacology; Toxicology; Tubocurarine
PubMed: 14261047
DOI: No ID Found -
British Journal of Anaesthesia Feb 1972
Topics: Acute Kidney Injury; Adjuvants, Anesthesia; Humans; Kidney Failure, Chronic; Kinetics; Models, Biological; Time Factors; Tubocurarine
PubMed: 5016882
DOI: 10.1093/bja/44.2.163 -
Biochimica Et Biophysica Acta Aug 1991Some investigation in this laboratory pointed to an unexpectedly slow inhibition of cholinesterase by D-tubocurarine, occurring in addition to a typically instantaneous...
Some investigation in this laboratory pointed to an unexpectedly slow inhibition of cholinesterase by D-tubocurarine, occurring in addition to a typically instantaneous inhibition. In order to elucidate this phenomenon, the hydrolysis of butyrylthiocholine catalyzed by cholinesterase was recorded, in the absence and presence of D-tubocurarine, on a stopped-flow apparatus. Experimental results were analyzed by classical kinetic methods and by means of mathematical modeling. It was found that the inhibition is of a double character, consisting of an instantaneous phase and a slow one occurring in a minute time scale. It seems that the action of D-tubocurarine is a consequence of an instantaneous binding of D-tubocurarine to a peripheral site, followed by a relatively slow conformational transition in the enzyme.
Topics: Butyrylthiocholine; Catalysis; Cholinesterase Inhibitors; Hydrolysis; Tubocurarine
PubMed: 1888768
DOI: 10.1016/0167-4838(91)90029-y -
The Journal of Pharmacology and... Jul 1950
Topics: Enzymes; Tubocurarine
PubMed: 15437309
DOI: No ID Found -
Anesthesiology Aug 1995Increases in acetylcholine receptors (AChRs) at the muscle membrane, induced by burn injury, have been associated with a hyperkalemic response to succinylcholine and...
BACKGROUND
Increases in acetylcholine receptors (AChRs) at the muscle membrane, induced by burn injury, have been associated with a hyperkalemic response to succinylcholine and resistance to d-tubocurarine-like drugs. Muscle relaxants often are administered to burn-injured patients in the intensive care unit to facilitate mechanical ventilation. This study in rats tested whether continuous administration of d-tubocurarine in subparalytic doses exaggerates the upregulation of AChRs induced by burn trauma. Subparalytic doses were used to avoid the confounding effects of immobilization.
METHODS
Three days after an approximate 50% body surface area burn or sham injury, the animals received an infusion of 3.03 +/- 0.05 micrograms/h of d-tubocurarine or equal volume of saline directly to the left gastrocnemius muscle via catheter connected to a subcutaneously implanted osmotic pump. After 7 days of d-tubocurarine or saline infusion, the AChRs were quantitated using 125I-alpha-bungarotoxin. The AChRs on the d-tubocurarine or saline-infused left gastrocnemius were compared to the contralateral gastrocnemius in the same group. The right or left gastrocnemius AChRs were compared to the ipsilateral muscles between groups. These intra- and intergroup comparisons allowed the delineation of the effects of catheter irritation, burns, or d-tubocurarine on AChRs.
RESULTS
Daily examination of the withdrawal response to toe-pinch revealed no evidence of paralysis. Weight loss in the burn-injury animals receiving d-tubocurarine or saline was similar, confirming that the infusion of d-tubocurarine did not impair the mobility of the animals to move and feed. The plasma d-tubocurarine concentration after 7 days of infusion was 26.0 +/- 12 ng/ml (mean +/- SE). Regardless of burn or sham injury or of d-tubocurarine or saline infusion, the concentration of AChRs on the left was consistently greater than in the contralateral right gastrocnemius muscles within the same group, indicating that manipulation of the area alone can result in upregulation of AChRs. The AChRs in the right gastrocnemius of burn-injured animals were greater than those in the same muscle of sham-injured animals, regardless of saline (7.24 +/- 0.9 vs. 5.7 +/- 0.5 fmoles/mg protein, P = 0.06) or d-tubocurarine (7.3 +/- 0.4 vs. 5.7 +/- 0.5, P < 0.05) infusion to the burn-injury groups. AChRs in the left gastrocnemius of burn-injury animals receiving d-tubocurarine were significantly greater than those in burn- or sham-injury animals receiving saline (13.9 +/- 1.1 vs. 9.8 +/- 1.2 and 7.1 +/- 0.5 fmoles/mg protein, respectively, P < 0.05).
CONCLUSIONS
Burn-induced upregulation of AChRs is accentuated by infusion of subparalytic doses of d-tubocurarine. Concomitant administration of d-tubocurarine to burn-injured patients may result in further exaggeration of the aberrant responses to neuromuscular relaxants.
Topics: Animals; Body Weight; Burns; Male; Muscles; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tubocurarine
PubMed: 7631953
DOI: 10.1097/00000542-199508000-00011