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The Journal of Hand Surgery Dec 2017Tumor-like conditions of the hand and upper extremity typically present as masses and can be confused as more serious conditions. The differential diagnosis of these... (Review)
Review
Tumor-like conditions of the hand and upper extremity typically present as masses and can be confused as more serious conditions. The differential diagnosis of these lesions can cross over with many more commonly recognized benign and malignant upper limb tumors, and it is, therefore, important for the hand surgeon to be familiar with tumor-like conditions. The diagnosis of these lesions often can be made on clinical grounds supported by a careful physical examination and plain film radiography. Advanced imaging and excisional biopsy may be needed in many circumstances to secure the diagnosis given their similarity with bone and soft tissue sarcomas.
Topics: Connective Tissue Diseases; Cysts; Diagnosis, Differential; Hamartoma; Hand; Humans; Musculoskeletal Diseases
PubMed: 29089162
DOI: 10.1016/j.jhsa.2017.09.012 -
The American Journal of the Medical... Jul 2018Solitary laryngeal neurofibromas are exceedingly rare with only 14 cases reported in the previous literature. Herein, we reported a case of solitary laryngeal... (Review)
Review
Solitary laryngeal neurofibromas are exceedingly rare with only 14 cases reported in the previous literature. Herein, we reported a case of solitary laryngeal neurofibroma and reviewed all the published cases of this disease on the clinical manifestations and management options. Patients with solitary laryngeal neurofibromas can present with a variety of respiratory symptoms. Immunohistochemical examination of tumor specimen is critical for pathologic diagnosis and complete surgical resection is the optimal therapy. Endoscopic microsurgeries followed by CO laser management of the surgical border may be effective on preventing recurrence. Depending on the location, size and invasiveness of the lesions, the management and prognosis vary among patients. Long-term follow-up is highlighted owing to the possibility of recurrence during a long period of time after surgery.
Topics: Humans; Immunohistochemistry; Laryngeal Neoplasms; Laryngoscopy; Laser Therapy; Neoplasm Recurrence, Local; Neurofibroma
PubMed: 30049332
DOI: 10.1016/j.amjms.2017.12.005 -
The Journal of Craniofacial SurgeryAn intracranial nerve-enteric cyst is a relatively rare benign disease, and the main clinical manifestations are related to the location and size of the cyst. The main...
An intracranial nerve-enteric cyst is a relatively rare benign disease, and the main clinical manifestations are related to the location and size of the cyst. The main symptoms are caused by cyst compression. When the cyst is small without compression, it may have no obvious symptoms, and when the cyst increases to a certain degree, it may cause corresponding clinical manifestations. The diagnosis of this disease is mainly based on clinical manifestations, imaging examinations, and pathological examinations. The authors present a 47-year-old woman who was admitted to the hospital with "dizziness". Imaging was performed and revealed a small round lesion in the posterior cranial fossa in front of the brainstem. It was surgically removed and the postoperative pathology revealed an intracranial neuro-enteric cyst. The patient's dizziness disappeared after surgery and was reviewed 1 year later without recurrence.
Topics: Female; Humans; Middle Aged; Magnetic Resonance Imaging; Cysts; Cranial Fossa, Posterior; Dizziness; Physical Examination
PubMed: 37101318
DOI: 10.1097/SCS.0000000000009333 -
Atlas of the Oral and Maxillofacial... Mar 2015
Review
Topics: Biopsy; Branchioma; Child; Head and Neck Neoplasms; Humans; Infections; Medical History Taking; Neck; Physical Examination; Thyroglossal Cyst
PubMed: 25707561
DOI: 10.1016/j.cxom.2014.10.002 -
Dermatology Online Journal Oct 2011A 59-year-old man presented for evaluation and excision of non-tender, fleshy nodules that were arranged in a dermatomal distribution from the left side of the chest to... (Review)
Review
A 59-year-old man presented for evaluation and excision of non-tender, fleshy nodules that were arranged in a dermatomal distribution from the left side of the chest to the left axilla. A biopsy specimen of a nodule was consistent with a neurofibroma. Owing to the lack of other cutaneous findings, the lack of a family history of neurofibromatosis, and the dermatomal distribution of the neurofibromas, this patient met the criteria for a diagnosis of segmental neurofibromatosis (SNF) according to Riccardi's definition of SNF and classification of neurofibromatosis. Because the patient has no complications of neurofibromatosis 1 no medical treatment is required.
Topics: Humans; Male; Middle Aged; Neurofibromatosis 1; Physical Examination; Prevalence
PubMed: 22031651
DOI: No ID Found -
Ceska a Slovenska Oftalmologie :... 2020Eye globe enucleation due to other than a malignant tumor is very rare today. Solitary intraocular neurofibroma without other signs of neurofibromatosis is a rare...
PURPOSE
Eye globe enucleation due to other than a malignant tumor is very rare today. Solitary intraocular neurofibroma without other signs of neurofibromatosis is a rare benign tumor and few cases have been reported to date.
MATERIAL AND METHODS
In 10 year interval from Jan 1 2007 to Dec 31 2016 we analyzed non-malignant eye globe enucleations.
RESULTS
Of the 49 enucleated blind eyes, each patient had visual acuity with no light perception, 34 (69.4%) were indicated for enucleation due to complications following previous postoperative surgery after trauma, 14 patients (28.6%) were due to secondary glaucoma and other complications following previous intraocular surgery, and in one patient (2%) the primary isolated intraocular neurofibroma was verified after enucleation.
CASE REPORT
A patient with isolated intrabulbar neurofibroma has been monitored since childhood for intraocular lesion and histologically verified at adult age. At the time of enucleation, he was 25 years old, squint since childhood and was observed for hamartoma in his right eye since he was 13 years old. Due to the progression of intrabulbar lesion, loss of visual acuity (functional state - no light perception) and secondary glaucoma, the right eye globe was enucleated at adult age and histopathological examination confirmed intraocular neurofibroma in the absence of neurofibromatosis.
CONCLUSION
Every enucleated eye globe should be subjected to a thorough histopathological examination. Isolated intraocular neurofibromas can occur as isolated orbital or intrabulbar masses without systemic features.
Topics: Adolescent; Adult; Child; Eye Enucleation; Eye Neoplasms; Glaucoma; Humans; Male; Neurofibroma; Visual Acuity
PubMed: 33126800
DOI: 10.31348/2020/13 -
The Nurse Practitioner Apr 2000Neck masses often present a diagnostic challenge to the primary care provider: Etiologies range from benign inflammations to life-threatening malignancies. Categorizing... (Review)
Review
Neck masses often present a diagnostic challenge to the primary care provider: Etiologies range from benign inflammations to life-threatening malignancies. Categorizing the etiologies into three broad categories is helpful when considering the extensive differential diagnosis for a neck mass: congenital, inflammatory/infectious, and neoplastic causes. This article discusses the evaluation and subsequent determination of whether a neck mass is significant and warrants further evaluation or is insignificant and may simply be observed. By performing a through history and physical examination, primary care providers can narrow the possibilities, differentiate between significant and insignificant neck masses, and select the appropriate treatment.
Topics: Adolescent; Adult; Child; Cysts; Diagnosis, Differential; Female; Head and Neck Neoplasms; Humans; Infections; Lymphatic Diseases; Male; Neck
PubMed: 10790797
DOI: 10.1097/00006205-200025040-00002 -
Journal of Neuro-oncology Mar 2010A 32-year-old man had seizure attack since April 2008 and radiographic examination revealed a heterogeneous enhancing mass at the left subfrontal region. He underwent... (Review)
Review
A 32-year-old man had seizure attack since April 2008 and radiographic examination revealed a heterogeneous enhancing mass at the left subfrontal region. He underwent craniotomy for tumor removal on October 1, 2008. The tumor, which was grayish white with glistening appearance and rubbery consistency, was traced to the proximal part of left olfactory tract. Histopathological examination revealed a hypocellular tumor with dense hyalinization in most areas. The tumor cells had ovoid to elongate and often comma-shaped nucleus. Myxoid change of the stroma was apparent in places. Most of the tumor cells were immuno-reactive for S-100 protein. Staining for Leu 7 (CD57 or HNK-1) was negative. Bodian method illustrated many axons within the tumor. Ultrastructural study of the tumor cells showed features compatible with those of olfactory ensheathing cell. The tumor was designated as olfactory ensheathing cell tumor with neurofibroma-like features. There have been 14 nerve sheath tumors arising from the olfactory nerve reported in the literature; all of them had the morphology of schwannoma. Our case, which had the morphology simulating neurofibroma was the first of its kind to be recorded.
Topics: Adult; Brain Neoplasms; Humans; Magnetic Resonance Imaging; Male; Microscopy, Electron, Transmission; Neurilemmoma; Neurofibroma; Olfactory Bulb; Olfactory Pathways
PubMed: 19690802
DOI: 10.1007/s11060-009-9986-1 -
Radiologic Clinics of North America Jan 2018Fibroosseous lesions in the jaws have similar histologic and radiographic features. Despite their similarity, management varies significantly. In this article, common... (Review)
Review
Fibroosseous lesions in the jaws have similar histologic and radiographic features. Despite their similarity, management varies significantly. In this article, common fibroosseous lesions and key radiographic features are described. Many of the fibroosseous lesions are diagnosed radiographically, without performing histologic examinations. For some of the fibroosseous lesions, for example, periapical osseous dysplasia, histologic examination is contraindicated. Cherubism and fibrous dysplasia have specific radiographic findings; these conditions can be diagnosed radiographically. Accurate diagnosis conditions is essential; some conditions do not require any intervention, while others require surgical resection. Patient demographics, for example, age, gender, and race, play important roles in diagnosis.
Topics: Diagnosis, Differential; Fibroma, Ossifying; Humans; Jaw Cysts; Jaw Diseases; Medical History Taking; Periapical Diseases; Physical Examination; Radiography, Dental
PubMed: 29157551
DOI: 10.1016/j.rcl.2017.08.007 -
The Journal of the American Academy of... Nov 2012Benign tumors in the spine include osteoid osteoma, osteoblastoma, aneurysmal bone cyst, osteochondroma, neurofibroma, giant cell tumor of bone, eosinophilic granuloma,... (Review)
Review
Benign tumors in the spine include osteoid osteoma, osteoblastoma, aneurysmal bone cyst, osteochondroma, neurofibroma, giant cell tumor of bone, eosinophilic granuloma, and hemangioma. Although some are incidental findings, some cause local pain, radicular symptoms, neurologic compromise, spinal instability, and deformity. The evaluation of spinal tumors includes a thorough history and physical examination, imaging, sometimes laboratory evaluation, and biopsy when indicated. Appropriate treatment may be observational (eg, eosinophilic granuloma) or ablative (eg, osteoid osteoma, neurofibroma, hemangioma), but generally is surgical, depending on the level of pain, instability, neurologic compromise, and natural history of the lesion. Knowledge of the epidemiology, common presentation, imaging, and treatment of benign bone tumors is essential for successful management of these lesions.
Topics: Bone Cysts, Aneurysmal; Bone Neoplasms; Eosinophilic Granuloma; Giant Cell Tumor of Bone; Hemangioma; Humans; Neurofibroma; Osteoblastoma; Osteochondroma; Osteoma, Osteoid; Prognosis; Spinal Diseases; Treatment Outcome
PubMed: 23118137
DOI: 10.5435/JAAOS-20-11-715