-
Journal of Cosmetic Dermatology Nov 2021Photoaging, ultra violet (UV) induced skin aging is a gradual process that depends on the time and intensity of solar radiation. (Review)
Review
BACKGROUND
Photoaging, ultra violet (UV) induced skin aging is a gradual process that depends on the time and intensity of solar radiation.
AIM
The aim of this paper was to review of the literature focused on in vitro studies explaining the mechanisms of photoaging.
METHODS
Electronic databases, including PubMed and MEDLINE, were searched for in vitro studies on the importance of UV radiation in the skin photoaging process of peer-reviewed scientific journals. Only articles available in English and full version publications were considered for this review.
RESULTS
Three main modes of UV radiation action on skin cells which lead to photoaging, there are changes in cell metabolism, induction of oxidative stress due to the change in enzyme activity.
CONCLUSION
The information gathered in this publication will help to better understand the complex and multidirectional mechanism of skin photoaging, which will contribute to the development of research on potential cosmetic products that provide effective and safe sun protection or repair damage caused by UV radiation.
Topics: Cosmetics; Oxidative Stress; Skin; Skin Aging; Ultraviolet Rays
PubMed: 33655657
DOI: 10.1111/jocd.14033 -
Redox Biology Nov 2021The ultraviolet B radiation (UVB) causes skin inflammation, which contributes to the causality and the exacerbation of a number of cutaneous diseases. However, the...
The ultraviolet B radiation (UVB) causes skin inflammation, which contributes to the causality and the exacerbation of a number of cutaneous diseases. However, the mechanism of UVB-driven inflammation in the skin remains poorly understood. We show that ferroptosis, a non-apoptotic programmed cell death pathway that is promoted by an excessive phospholipid peroxidation, is activated in the epidermal keratinocytes after their exposure to UVB. The susceptibility of the keratinocytes to UVB-induced ferroptosis depends on the extent of pro-ferroptosis death signal generation and the dysregulation of the glutathione system. Inhibition of ferroptosis prevents the release of HMGB1 from the human epidermal keratinocytes, and blocks necroinflammation in the UVB-irradiated mouse skin. We show that while apoptosis and pyroptosis are also detectable in the keratinocytes after UVB exposure, ferroptosis plays a significant role in initiating UVB-induced inflammation in the skin. Our results have important implications for the prevention and the treatment of a broad range of skin diseases which are fostered by UVB-induced inflammation.
Topics: Animals; Apoptosis; Ferroptosis; Inflammation; Keratinocytes; Mice; Skin; Ultraviolet Rays
PubMed: 34592565
DOI: 10.1016/j.redox.2021.102143 -
The New England Journal of Medicine Apr 2012
Topics: Aged; Face; Humans; Male; Skin; Skin Aging; Ultraviolet Rays
PubMed: 22512500
DOI: 10.1056/NEJMicm1104059 -
Dermatology Online Journal Nov 2017Exploring the mountains is a highly rewarding past time; however, certain high-altitude exposures can lead to dermatologic manifestations. In this review article, the... (Review)
Review
Exploring the mountains is a highly rewarding past time; however, certain high-altitude exposures can lead to dermatologic manifestations. In this review article, the authors will describe cold, solar, and severe weather that one may experience when spending time outdoors. Factors such as increased ultraviolet radiation, temperature extremes, and low partial pressure of oxygen, along with human physiologic parameters also contribute to disease severity and presentation. This review article will address the diagnosis, treatment, and prevention of high-altitude dermatology exposures.
Topics: Altitude; Cold Injury; Dermatology; Humans; Mountaineering; Skin Diseases; Ultraviolet Rays; Weather
PubMed: 29447629
DOI: No ID Found -
International Journal of Environmental... Aug 2018Overexposure to solar ultraviolet (UV) radiation is a risk for public health. Therefore, it is important to provide information to the public about the level of solar... (Review)
Review
Overexposure to solar ultraviolet (UV) radiation is a risk for public health. Therefore, it is important to provide information to the public about the level of solar UV. The UV-Index (UVI) is the relevant quantity, expressing the erythemally weighted irradiance to a horizontal plane on a simple scale. As solar UV irradiance is strongly variable in time and space, measurements within a network provide the best source of information, provided they can be made available rapidly. However, to ensure the information is reliable, strict quality assurance/quality control (QA/QC) procedures for the monitoring networks are necessary. Near real time presentation of the measured UVI on web-pages is the best way to inform the public. The interpretation of the data in terms of the individual 'allowable' exposure time is heavily impacted by skin type, behavior, and clothing, and must be learned for each person through experience and guidance. Nonetheless, reliable knowledge of the actual level of the intensity of erythemally weighted irradiance and its variability forms the basis of education and public awareness. The challenges and requirements in providing comprehensive UVI data for public health guidance are here considered.
Topics: Humans; Public Health; Radiation Monitoring; Ultraviolet Rays
PubMed: 30103479
DOI: 10.3390/ijerph15081723 -
The British Journal of Ophthalmology Jun 2006Can we provide medical and not surgical cure?
Can we provide medical and not surgical cure?
Topics: Humans; Insulin-Like Growth Factor Binding Protein 3; Pterygium; Ultraviolet Rays
PubMed: 16714259
DOI: 10.1136/bjo.2006.091413 -
British Medical Journal (Clinical... Jan 1983
Topics: Beds; Consumer Product Safety; Humans; Skin; Ultraviolet Rays
PubMed: 6402085
DOI: 10.1136/bmj.286.6362.329 -
Current Opinion in Rheumatology Mar 2021Skin injury is the most common clinical manifestation of SLE and is disfiguring, difficult to treat, and incompletely understood. We provide an overview of recently... (Review)
Review
PURPOSE OF REVIEW
Skin injury is the most common clinical manifestation of SLE and is disfiguring, difficult to treat, and incompletely understood. We provide an overview of recently published articles covering the immunopathogenesis of skin injury in SLE.
RECENT FINDINGS
Skin of SLE has an inherent susceptibility to apoptosis, the cause of which may be multifactorial. Chronic IFN overexpression leads to barrier disruption, infiltration of inflammatory cells, cytokine production, and release of autoantigens and autoantibody production that result in skin injury. Ultraviolet light is the most important CLE trigger and amplifies this process leading to skin inflammation and potentially systemic disease flares.
SUMMARY
The pathogenesis of skin injury in CLE is complex but recent studies highlight the importance of mechanisms driving dysregulated epidermal cell death likely influenced by genetic risk factors, environmental triggers (UV light), and cytotoxic cells and cellular signaling.
Topics: Autoantigens; Humans; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Skin; Ultraviolet Rays
PubMed: 33315653
DOI: 10.1097/BOR.0000000000000770 -
Current Biology : CB Jul 2021Robson et al.'s commentary on our article, 'Floral pigmentation has responded rapidly to global change in ozone and temperature', questions the study's conclusion that...
Robson et al.'s commentary on our article, 'Floral pigmentation has responded rapidly to global change in ozone and temperature', questions the study's conclusion that floral ultraviolet (UV) pigmentation has responded to global change, particularly to total column ozone (TCO). Robson et al. claim that our study spanned a time frame in which ozone was not declining and suggest no biological relationship between UV-B exposure and UV floral pigmentation. To support their claims, they selectively remove and reanalyze data. We respond with a critique of their interpretations of our results, and analyses of temporal patterns of TCO data from Koski et al.. Despite Robson et al.'s concerns, our study continues to support a link between temporal changes in ozone and temperature, and temporal changes in UV floral pigmentation.
Topics: Ozone; Pigmentation; Temperature; Ultraviolet Rays
PubMed: 34314710
DOI: 10.1016/j.cub.2021.06.020 -
Current Sports Medicine Reports Apr 2020Overexposure to ultraviolet radiation (UVR) from the sun is associated with deleterious health effects including, but not limited to, increased risk of skin cancers.... (Review)
Review
Overexposure to ultraviolet radiation (UVR) from the sun is associated with deleterious health effects including, but not limited to, increased risk of skin cancers. Military personnel and those who participate in outdoor exercise or sports represent two potential populations at elevated risk of negative health consequences of UVR exposure due to large amounts of time spent outdoors, often in harsh UVR environments. Despite exposure to high and/or frequent doses of UVR in recreational and tactical athletes, adequate sun-protection practices are often disregarded or not well understood by many within these at-risk populations, resulting in heightened risk of negative UVR effects. The focus of this review is to examine the available literature regarding UVR exposure, risk of adverse health effects of UVR exposure, and sun protection practices in outdoor exercisers, athletes, and military personnel.
Topics: Athletes; Exercise; Humans; Military Personnel; Radiation Exposure; Sunburn; Sunscreening Agents; Ultraviolet Rays
PubMed: 32282458
DOI: 10.1249/JSR.0000000000000702