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British Medical Journal Feb 1970
Topics: Humans; Methods; Methylene Blue; Peptic Ulcer; Vagotomy; Vagus Nerve
PubMed: 5435202
DOI: 10.1136/bmj.1.5695.565 -
Respiratory Physiology & Neurobiology Aug 2010Respiratory-modulated facial (VII) nerve discharge includes pre-inspiratory (Pre-I) and inspiratory (I) components. Tonic VII bursting is also present across the...
Respiratory-modulated facial (VII) nerve discharge includes pre-inspiratory (Pre-I) and inspiratory (I) components. Tonic VII bursting is also present across the respiratory cycle. We tested the hypothesis that hypoxia-induced plasticity of VII motor activity is differentially expressed in Pre-I, I and tonic bursting. Phrenic and VII neurograms were recorded in urethane-anesthetized, vagotomized and ventilated adult rats. A 3 min isocapnic hypoxic challenge (PaO(2)=33+/-2 mmHg) was used to evoke respiratory short-term potentiation (STP). Pre-I, I and tonic VII activity increased immediately at the initial stage of hypoxia (i.e. acute response) and then progressively increased as hypoxia was maintained. Following hypoxia, I VII activity remained elevated (i.e. post-hypoxia STP) but both Pre-I and tonic activity immediately returned to baseline values. We conclude that STP following hypoxia is preferentially expressed in I compared to Pre-I and tonic VII activity.
Topics: Action Potentials; Animals; Blood Gas Analysis; Blood Pressure; Hypoxia; Motor Neurons; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Respiration; Time Factors; Vagotomy
PubMed: 20601212
DOI: 10.1016/j.resp.2010.06.015 -
Gut Aug 1973The effects of varying the extent of vagotomy on the myoelectrical and motor activity of the stomach have been successfully studied in 21 patients undergoing either...
The effects of varying the extent of vagotomy on the myoelectrical and motor activity of the stomach have been successfully studied in 21 patients undergoing either truncal, selective, or highly selective vagotomy for the treatment of chronic duodenal ulceration. The mean percentage time that regular antral myoelectrical activity was recorded preoperatively was 95.8% +/- 1.0 and this was decreased following highly selective vagotomy (74.0% +/- 6.6), selective vagotomy (37.8% +/- 12.4), and truncal vagotomy (30.2% +/- 10.4). The mean amplitude of the pacesetter potential was less following truncal (0.86 mV +/- 0.05), selective (1.32 mV +/- 0.09), and highly selective vagotomy (1.67 +/- 0.09) than in preoperative studies (2.21 mV +/- 0.12). Following truncal and selective vagotomies the triphasic waveform of the pacesetter potential changed to a sinusoidal shape. No significant change in the mean preoperative frequency of the myoelectrical activity (3.03 cpm +/- 0.08) occurred after vagotomy. Thus the changes in the electrical activity of the stomach are related to the extent of the vagal denervation. Intravenous administration of insulin did not alter these patterns except after highly selective vagotomy when the amplitude of the electrical waves, the incidence of action potentials, and percentage motor activity were increased.
Topics: Action Potentials; Adult; Duodenal Ulcer; Female; Gastrointestinal Motility; Humans; Injections, Intravenous; Insulin; Male; Middle Aged; Stomach; Vagotomy
PubMed: 4743496
DOI: 10.1136/gut.14.8.657 -
British Medical Journal Feb 1964
Topics: Duodenal Ulcer; Enterostomy; Gastrectomy; Gastroenterostomy; Humans; Postgastrectomy Syndromes; Postoperative Complications; Prognosis; Pylorus; Statistics as Topic; Vagotomy
PubMed: 14084670
DOI: 10.1136/bmj.1.5381.455 -
Physiology & Behavior Sep 2019The postoral actions of sugar and fat can rapidly stimulate the intake of and preference for flavors associated with these nutrients via a process known as appetition....
The postoral actions of sugar and fat can rapidly stimulate the intake of and preference for flavors associated with these nutrients via a process known as appetition. Prior findings revealed that postoral glucose appetition is not attenuated following capsaicin-induced visceral deafferentation. The present experiment determined if capsaicin treatment altered fat appetition in C57BL/6 mice. Following capsaicin (Cap) or control (Con) treatment, mice were fitted with chronic intragastric (IG) catheters. They were then given 1-h sessions with a flavored saccharin solution (CS-) paired with IG water infusion or a different flavor (CS+) paired with IG 6.4% fat infusion. IG fat stimulated CS+ intakes in both Cap and Con mice, and the groups displayed similar preferences for CS+ over CS- in two-choice tests. These results confirm prior reports of normal fat conditioning in rats exposed to capsaicin or vagal deafferentation surgery. In contrast, other recent findings indicate that total or selective vagotomy alters the preference of mice for dilute vs. concentrated fat sources.
Topics: Animals; Capsaicin; Catheters, Indwelling; Conditioning, Psychological; Fats; Flavoring Agents; Food Preferences; Male; Mice; Mice, Inbred C57BL; Stomach; Taste; Vagotomy
PubMed: 31228498
DOI: 10.1016/j.physbeh.2019.112586 -
Gut Sep 1974The value of insulin and augmented histamine tests in predicting recurrence of duodenal ulcer within six to eight years after truncal vagotomy and drainage was assessed...
The value of insulin and augmented histamine tests in predicting recurrence of duodenal ulcer within six to eight years after truncal vagotomy and drainage was assessed in a series of 500 consecutively and electively operated patients. Criteria of recurrence were established by a discriminative analysis of gastric acid secretion parameters. Recurrence was predicted with a probability of about 75% in patients with dyspepsia, the proportion between recurrences and dyspeptic nonrecurrences being 1:1. The discriminatory ability of the insulin test was no better than that of the postoperative histamine test. Men with a preoperative PAO > 46.1 m-equiv/h had a risk of recurrence of 21%, women with a PAO > 41.5 m-equiv/h, 28%. Below these levels the risk was 5 and 1% respectively, demonstrating that recurrence after vagotomy is related to the number of parietal cells before vagotomy. A rationale is provided for antrectomy and vagotomy in duodenal ulcer patients with a high number of parietal cells.
Topics: Drainage; Duodenal Ulcer; Female; Follow-Up Studies; Gastric Juice; Histamine; Humans; Insulin; Male; Postoperative Complications; Recurrence; Secretory Rate; Sex Factors; Time Factors; Vagotomy
PubMed: 4435586
DOI: 10.1136/gut.15.9.714 -
The Tohoku Journal of Experimental... Jun 1952
Studies on the cardiac rhythm of the dog during bilateral thoracotomy and after vagotomy and esophagectomy. II. On the cardiac rhythm of the dog in the cervical and intrathoracic vagotomy.
Topics: Animals; Cardiovascular Physiological Phenomena; Dogs; Esophagectomy; Heart; Humans; Thoracotomy; Vagotomy; Vagus Nerve
PubMed: 13005495
DOI: 10.1620/tjem.56.119 -
British Medical Journal Mar 1974
Topics: Bile; Cholestyramine Resin; Diarrhea; Humans; Vagotomy
PubMed: 4817177
DOI: 10.1136/bmj.1.5906.519-a -
The Journal of Physiology Apr 19691. The effects of bilateral cervical vagotomy, of bilateral vagal cooling and of efferent vagal stimulation were studied on rabbits anaesthetized with pentobarbitone...
1. The effects of bilateral cervical vagotomy, of bilateral vagal cooling and of efferent vagal stimulation were studied on rabbits anaesthetized with pentobarbitone sodium. Total lung conductance, lung compliance, breathing frequency, tidal volume, end-tidal CO(2)%, systemic arterial and right atrial blood pressures and heart rate were measured. Some of the rabbits were first paralysed and artificially ventilated.2. The changes in lung conductance were consistent with the presence of a tonic efferent vagal discharge in bronchoconstrictor fibres, reflexly damped down by a tonic afferent vagal discharge dilator to the airways, probably the Hering-Breuer inflation reflex.3. Neither vagotomy nor efferent vagal stimulation significantly influenced lung compliance, right atrial pressure or end-tidal CO(2)%; vagal cooling lowered end-tidal CO(2)% in spontaneously breathing rabbits, but did not affect the other variables.4. Efferent vagal stimulation in the rabbit decreased lung conductance with no significant change in lung compliance.5. In the rabbit, vagal efferent activity affects primarily the larger (resistance) air passages with little action on the distal (compliance-influencing) airways.
Topics: Animals; Blood Pressure; Cold Temperature; Electric Stimulation; Heart Rate; Lung; Lung Compliance; Rabbits; Respiration; Vagotomy; Vagus Nerve
PubMed: 5780543
DOI: 10.1113/jphysiol.1969.sp008754 -
Annals of Surgery Mar 1961
Topics: Duodenal Ulcer; Hemorrhage; Humans; Peptic Ulcer Hemorrhage; Research Report; Sutures; Vagotomy
PubMed: 13723977
DOI: 10.1097/00000658-196103000-00007