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Acta Cirurgica Brasileira 2021To evaluate the influence of autonomic vagal and splenic activities on renal histomorphometric aspects in obese rats.
PURPOSE
To evaluate the influence of autonomic vagal and splenic activities on renal histomorphometric aspects in obese rats.
METHODS
Thirty male Wistar rats were used, of which, 24 received subcutaneous injections of monosodium glutamate (MSG) during the first 5 days of life (4 g/kg body weight) and six control animals received injections of saline solution (CON). Five experimental groups were organized (n = 6/group): falsely-operated control (CON-FO); falsely-operated obese (MSG-FO); vagotomized obese (MSG-VAG); splenectomized obese (MSG-SPL); vagotomized and splenectomized obese (MSG-VAG-SPL).
RESULTS
The MSG-FO group animals showed a significant reduction in body weight and nasal-anal length when compared to CON-FO group animals (p < 0.05). The MSG-VAG-SPL group showed significant reduced in most biometric parameters associated with obesity. Falsely-operated obese animals showed a significant reduction in renal weight, glomerular diameters, glomerular tuff and capsule areas and Bowman's space compared to CON-FO group animals (p < 0.05). There was a significant reduction in diameter, glomerular tuft and capsule areas, and Bowman's space in MSG-VAG, MSG-SPL, MSG-VAG-SPL groups when compared to the MSG-FO group.
CONCLUSIONS
Vagotomy associated with splenectomy induces a reduction in the adiposity and causes histological changes in the kidney of obese rats.
Topics: Animals; Kidney; Lipids; Male; Obesity; Rats; Rats, Wistar; Splenectomy; Vagotomy
PubMed: 33624722
DOI: 10.1590/ACB360205 -
The Yale Journal of Biology and Medicine 1994Peptic ulcer surgery has been revitalized by the introduction of minimal access techniques for surgery of chronic and perforated peptic ulcer. A wide range of... (Review)
Review
Peptic ulcer surgery has been revitalized by the introduction of minimal access techniques for surgery of chronic and perforated peptic ulcer. A wide range of vagotomies, including truncal vagotomy, anterior lesser curve seromyotomy with posterior truncal vagotomy and proximal gastric vagotomy, have been performed laparoscopically. Short-term (two-24 month) follow-up of laparoscopic anterior seromyotomy with posterior truncal vagotomy cases has been promising, but long-term follow-up is required to confirm these early good results. Laparoscopic repair of perforated peptic ulcers has also been described. Initial reports of laparoscopic gastrojejunostomy and Billroth II partial gastrectomy have also appeared. These procedures are technically very demanding and are currently being performed in only a few "centers of excellence" around the world. Cost-benefit analyses of medical treatment with proton-pump inhibitors versus laparoscopic vagotomy are necessary to determine which form of treatment is more economical in the long run. Criteria for patient selection need to be defined and substantiated by audit of outcome.
Topics: Humans; Laparoscopy; Peptic Ulcer; Stomach; Vagotomy
PubMed: 7502525
DOI: No ID Found -
British Medical Journal (Clinical... Jun 1982
Topics: Diarrhea; Dumping Syndrome; Duodenal Ulcer; Gastroesophageal Reflux; Humans; Postoperative Complications; Recurrence; Reoperation; Vagotomy
PubMed: 6805708
DOI: 10.1136/bmj.284.6332.1815 -
Gut Jul 1982Duodenogastric reflux of bile acids and lysolecithin in the course of a standard test meal was measured in normal people and in patients with duodenal ulcer before... (Comparative Study)
Comparative Study
Bile acid and lysolecithin concentrations in the stomach in patients with duodenal ulcer before operation and after treatment by highly selective vagotomy, partial gastrectomy, or truncal vagotomy and drainage.
Duodenogastric reflux of bile acids and lysolecithin in the course of a standard test meal was measured in normal people and in patients with duodenal ulcer before operation and more than one year after highly selective vagotomy, Polya partial gastrectomy, truncal vagotomy and pyloroplasty, and truncal vagotomy and gastrojejunostomy. Before operation, duodenal ulcer patients had significantly higher fasting, post-prandial, and peak bile acid concentrations in the stomach than had normal subjects. After Polya partial gastrectomy, fasting, post-prandial, and peak concentrations of bile acids and lysolecithin were significantly higher than in preoperative duodenal ulcer patients. After highly selective vagotomy, in contrast, bile acid concentrations in the stomach were significantly lower than in preoperative duodenal ulcer patients and post-prandial and peak lysolecithin concentrations were less than half (NS) those recorded in preoperative duodenal ulcer patients. After highly selective vagotomy, bile acid concentrations were also significantly lower than bile acid concentrations after Polya partial gastrectomy, truncal vagotomy and pyloroplasty, and truncal vagotomy and gastrojejunostomy; and post-prandial and peak lysolecithin concentrations were significantly lower than after Polya partial gastrectomy and truncal vagotomy and gastrojejunostomy. Thus, when used in the treatment of patients with duodenal ulcer, highly selective vagotomy keeps ;bile' out of the stomach, probably through its effect on gastric smooth muscle, combined with the preservation of an intact antropyloroduodenal segment. In contrast, Polya partial gastrectomy, truncal vagotomy and gastrojejunostomy, and truncal vagotomy and pyloroplasty all lead to a significant increase in reflux of bile acids and lysolecithin into the stomach. The clinical importance of these findings is that both gastritis and, in the long term, gastric carcinoma may prove to be less common after highly selective vagotomy than after partial gastrectomy or vagotomy with a drainage procedure.
Topics: Adult; Aged; Bile Acids and Salts; Drainage; Duodenal Ulcer; Gastrectomy; Gastric Juice; Humans; Lysophosphatidylcholines; Male; Middle Aged; Postoperative Period; Vagotomy; Vagotomy, Proximal Gastric
PubMed: 7084804
DOI: 10.1136/gut.23.7.569 -
Annals of Surgery Oct 1970
Clinical Trial Randomized Controlled Trial
Topics: Adult; Drainage; Duodenal Ulcer; Duodenum; Follow-Up Studies; Gastrectomy; Gastric Juice; Gastroenterostomy; Humans; Insulin; Jejunum; Male; Middle Aged; Postoperative Complications; Prospective Studies; Pylorus; Secretory Rate; Vagotomy
PubMed: 5458615
DOI: 10.1097/00000658-197010000-00003 -
British Medical Journal Feb 1972
Topics: Duodenal Ulcer; Humans; Insulin; Pylorus; Vagotomy
PubMed: 5015056
DOI: 10.1136/bmj.1.5799.568-b -
American Journal of Physiology.... Sep 2000Both total subdiaphragmatic vagotomy (TVAGX) and serotonin(3) receptor blockade with tropisetron or ondansetron attenuate amino acid-imbalanced diet (Imb) anorexia.... (Comparative Study)
Comparative Study
Both total subdiaphragmatic vagotomy (TVAGX) and serotonin(3) receptor blockade with tropisetron or ondansetron attenuate amino acid-imbalanced diet (Imb) anorexia. Total vagotomy is less effective than tropisetron in reducing Imb-induced anorexia and also blunts the tropisetron effect. With the use of electrocautery at the subdiaphragmatic level of the vagus, we severed the ventral and dorsal trunks as well as the hepatic, ventral gastric, dorsal gastric, celiac, and accessory celiac branches separately or in combination to determine which vagal branches or associated structures may be involved in these responses. Rats were prefed a low-protein diet. On the first experimental day, tropisetron or saline was given intraperitoneally 1 h before presentation of Imb. Cuts including the ventral branch, i.e., TVAGX, ventral vagotomy (above the hepatic branch), and hepatic + gastric vagotomies (but not hepatic branch cuts alone) caused the highest (P < 0.05) Imb intake on day 1 with or without tropisetron. The responses to tropisetron were not affected significantly. On days 2-8, groups having vagotomies that included the hepatic branch recovered faster than sham-treated animals. Because the hepatic and gastric branches together account for most of the vagal innervation to the proximal duodenum, this area may be important in the initial responses, whereas structures served by the hepatic branch alone apparently act in the later adaptation to Imb.
Topics: Adaptation, Physiological; Amino Acids; Animals; Anorexia; Body Weight; Diaphragm; Diet; Duodenum; Eating; Indoles; Liver; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Stomach; Tropisetron; Vagotomy; Vagus Nerve
PubMed: 10956259
DOI: 10.1152/ajpregu.2000.279.3.R997 -
British Medical Journal Feb 1978
Topics: Glucagon; Humans; Hypoglycemia; Vagotomy
PubMed: 626873
DOI: 10.1136/bmj.1.6111.512-a -
British Medical Journal Nov 1973
Topics: Adult; Bile; Cholestyramine Resin; Diabetes Complications; Diarrhea; Humans; Male; Middle Aged; Vagotomy
PubMed: 4749795
DOI: 10.1136/bmj.4.5889.423 -
British Medical Journal (Clinical... May 1984Seven hundred and thirty five patients who underwent elective vagotomy and drainage procedures in one hospital during 1957-67 were followed up until 1 September 1982. At...
Seven hundred and thirty five patients who underwent elective vagotomy and drainage procedures in one hospital during 1957-67 were followed up until 1 September 1982. At this time 281 were dead compared with an expected 184. This gives a ratio of observed to expected deaths of 1.53 (p less than 0.0001). The most important cause of increased mortality was lung cancer, which accounted for 33 of the excess deaths (observed to expected ratio 3.53). Gastric cancer yielded an observed to expected ratio of 3.3. Other causes of death that were significantly more common than expected were cerebrovascular accident, bronchopneumonia, and colorectal cancer. It is concluded that although gastric cancer occurs more commonly after vagotomy and drainage than in the general population, it is not as important a cause of death as diseases related to smoking.
Topics: Adolescent; Adult; Aged; Drainage; Duodenal Ulcer; Female; Follow-Up Studies; Humans; Male; Middle Aged; Vagotomy
PubMed: 6424847
DOI: 10.1136/bmj.288.6427.1335