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Anticancer Research 2006The effects of two recently discovered heparin binding growth factors, FGF-19 and FGF-20, on the human embryonal carcinoma derived cell line Tera 2 were examined.
BACKGROUND
The effects of two recently discovered heparin binding growth factors, FGF-19 and FGF-20, on the human embryonal carcinoma derived cell line Tera 2 were examined.
MATERIALS AND METHODS
Cell numbers, as well as cell migration were examined at the clonal level by light microscopy.
RESULTS
FGF-19, as well as FGF-20 promoted Tera 2 cell multiplication. Whereas FGF-20 promoted cell multiplication at low doses, FGF-19 was required at high doses to achieve a comparable effect. Moreover, FGF-19 did not significantly stimulate cell locomotion, while FGF-20 promoted cell motility at high doses.
CONCLUSION
FGF-19 and FGF-20 qualitatively exert different effects on cell survival and cell locomotion.
Topics: Carcinoma, Embryonal; Cell Movement; Cell Proliferation; Fibroblast Growth Factors; Humans; In Vitro Techniques; Recombinant Proteins; Tumor Cells, Cultured
PubMed: 17094445
DOI: No ID Found