Biologically Active Substance
Ficusin
pso·ra·len [ sawr-uh-luhn, sohr- ]
Definitions related to ficusin:
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A naturally occurring furocoumarin, found in PSORALEA. After photoactivation with UV radiation, it binds DNA via single and double-stranded cross-linking.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(psoralen) A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids.NCI ThesaurusU.S. National Cancer Institute, 2021
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(psoralen) A substance from plants that is sensitive to light (or can be activated by light). Psoralens are used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. They are also being studied in the treatment of graft-versus-host disease. Psoralen is a type of furocoumarin. An example of a psoralen is methoxsalen.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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(psoralen) Linear furocoumarins which are found in many plants; they can intercalate DNA and, in an ultraviolet initiated reaction of the furan portion, alkylate pyrimidines, causing photosensitivity.CRISP ThesaurusNational Institutes of Health, 2006
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