Biologically Active Substance
methoxsalen
[ me-thok-suh-luhn ]
Brand Names:
Oxsoralen; Uvadex
Effect:
Decreased DNA Integrity; Photosensitizing Activity
May Treat:
Mycosis Fungoides;
Psoriasis;
Vitiligo
More Information:
Definitions related to methoxsalen:
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A drug used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. It is also being studied in the treatment of graft-versus-host disease. It belongs to the family of drugs called psoralens and furocoumarins.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalen's exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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