Pharmacologic Substance
adapalene
Brand Names:
Differin; Epiduo
Effect:
Cellular Division Phase Alteration; Cellular Growth Phase Arrest; Decreased Epithelial Proliferation; Decreased Immunologically Active Molecule Activity; Decreased Sebaceous Gland Activity; Keratin Alteration
May Treat:
Acne Vulgaris
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to adapalene:
  • A naphthalene derivative that has specificity for RETINOIC ACID RECEPTORS. It is used as a DERMATOLOGIC AGENT for the treatment of ACNE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression. This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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