Pharmacologic Substance
cinacalcet hydrochloride
Effect:
Decreased PTH Secretion
May Treat:
Hyperparathyroidism, Primary;
Hyperparathyroidism, Secondary;
Parathyroid Neoplasms
More Information:
Definitions related to cinacalcet hydrochloride:
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A naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth.NCI ThesaurusU.S. National Cancer Institute, 2021
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