Pharmacologic Substance
cinacalcet hydrochloride
Effect:
Decreased PTH Secretion
May Treat:
Hyperparathyroidism, Primary; Hyperparathyroidism, Secondary; Parathyroid Neoplasms
More Information:
ChemID; DailyMed; DrugInfo; PDR
Definitions related to cinacalcet hydrochloride:
  • A naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • The orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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