Pharmacologic Substance
pravastatin
Brand Names:
Pravachol
Effect:
Decreased Cholesterol Synthesis
May Prevent:
Coronary Artery Disease
May Treat:
Coronary Artery Disease;
Hypercholesterolemia;
Hyperlipoproteinemias;
Hypertriglyceridemia
More Information:
Definitions related to pravastatin:
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A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke and heart attack. It is also being studied in the treatment of cancer and other conditions. Pravastatin blocks an enzyme that helps make cholesterol in the body. It may also make tumor cells more sensitive to anticancer drugs. It is a type of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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