Biologically Active Substance
alarmin
Subclass of:
Inflammation Mediators
Definitions related to alarmins:
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A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(damage-associated molecular pattern molecule) Molecules released during times of cellular stress or necrosis, that can induce or perpetuate the non-infectious immune response.NCI ThesaurusU.S. National Cancer Institute, 2021
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