Pharmacologic Substance
amiodarone
[ am-ee-oh-dar-ohn ]
Brand Names:
Cordarone; Nexterone; Pacerone
Effect:
Atrial Repolarization; Negative Chronotropy; Ventricular Repolarization
May Treat:
Tachycardia, Supraventricular;
Ventricular Fibrillation
More Information:
Definitions related to amiodarone:
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2-butyl-3-(3,5-diiodo-4-beta diethylaminoethoxybenzoyl) benzofuran; coronary vasodilator used as an antiarrhythmic; severe risk of pulmonary and hepatic toxicity via disruption of lysosomal function; also has amphiphilic phototoxin properties.CRISP ThesaurusNational Institutes of Health, 2006
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An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.NCI ThesaurusU.S. National Cancer Institute, 2021
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