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antisense oligonucleotide Audio
an·ti·sense ol·i·go·nu·cle·o·tide [ an-tee-sents ah-lih-goh-noo-klee-oh-tide ]
Subclass of:
Antisense Elements (Genetics); Oligonucleotides
Definitions related to antisense oligonucleotides:
  • Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways. Antisense agents may be used to block the production of proteins needed for cell growth. They are being studied in the treatment of several types of cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Antisense Oligonucleotides, short synthetic segments of DNA or RNA, designed with a sequence complimentary to a specific mRNA that target and bind with mRNA, causing inhibition of translation or overexpression of the protein encoded by the mRNA.
    NCI
    U.S. National Cancer Institute, 2021
  • (oligonucleotides, antisense) Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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