Organic Chemical
morpholino
Subclass of:
Oligonucleotides; Morpholines
Definitions related to morpholinos:
  • An antisense oligonucleotide modified to be more stable than RNA. While morpholinos have standard nucleic acid bases, those bases are bound to morpholine rings instead of deoxyribose rings and linked through phosphorodiamidate groups instead of phosphates. Morpholinos are used to inhibit translation or splicing of specific, complementary mRNAs.
    NCI
    U.S. National Cancer Institute, 2021
  • Synthetic analogs of NUCLEIC ACIDS composed of morpholine ring derivatives (MORPHOLINES) linked by phosphorodimidates. One standard DNA nucleic acid base (ADENINE; GUANINE; CYTOSINE; OR THYMINE) is bound to each morpholine ring.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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