Disease or Syndrome
aplastic anemia
a·plas·tic a·ne·mi·a [ ay-plas-tik uh-nee-mee-uh ]
Subclass of:
Bone Marrow Failure Disorders;
Anemia
Also called:
Hypoplastic Anemia
Definitions related to aplastic anemia:
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A condition in which the bone marrow is unable to produce blood cells.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia.NICHD Pediatric TerminologyU.S. National Cancer Institute, 2021
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Anemia associated with a fatty, hypocellular bone marrow and global dyshematopoiesis; can be idiopathic or due to microbial, metabolic, autoimmune, or other abnormality.CRISP ThesaurusNational Institutes of Health, 2006
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Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors.NCI ThesaurusU.S. National Cancer Institute, 2021
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Aplastic anemia is a rare but serious blood disorder. If you have it, your bone marrow doesn't make enough new blood cells. There are different types, including Fanconi anemia. Causes include Toxic substances, such as pesticides, arsenic, and benzene; Radiation therapy and chemotherapy for cancer; Certain medicines; Infections such as hepatitis, Epstein-Barr virus, or HIV; Autoimmune disorders; Certain inherited conditions; Pregnancy. In many people, the cause is unknown. Symptoms include fatigue, weakness, dizziness, and shortness of breath. It can cause heart problems such as an irregular heartbeat, an enlarged heart, and heart failure. You may also have frequent infections and bleeding. Your doctor will diagnose aplastic anemia based on your medical and family histories, a physical exam, and test results. Once your doctor knows the cause and severity of the condition, he or she can create a treatment plan for you. Treatments include blood transfusions, blood and marrow stem cell transplants, and medicines. NIH: National Heart, Lung, and Blood InstituteMedlinePlusU.S. National Library of Medicine, 2021
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Aplastic anemia is defined as pancytopenia with a hypocellular marrow.Human Phenotype Ontology (HPO)The Human Phenotype Ontology Project, 2021
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(anemia, aplastic) A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia...Merck & Co., Inc., 2020
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Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia. Although often normocytic, mild macrocytosis can also be observed in association with stress erythropoiesis and elevated fetal hemoglobin levels.WebMD, 2019
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Aplastic anemia is a condition that occurs when your body stops producing enough new blood cells. The condition leaves you fatigued and more prone to infections and uncontrolled bleeding.Mayo Foundation for Medical Education and Research
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Aplastic anemia is a blood disorder caused by failure of the bone marrow to make enough new blood cells. Bone marrow is a sponge-like tissue inside the bones that makes stem cells that develop into red blood cells, white blood cells, and platelets. Symptoms may include fatigue, weakness, dizziness, shortness of breath, frequent...National Center for Advancing Translational Sciences
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Aplastic anemia (AA) is defined by pancytopenia with hypocellular marrow and no abnormal cells. At least 2 of the following peripheral cytopenias must be present: Hb <10 g/dL, platelets <50 � 10^9/L, absolute neutrophil count <1.5 � 10^9/L. Bone marrow should show hypocellularity without evidence of significant dysplasia, blasts,...Athenahealth, Inc., 2019
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Aplastic anemia, disease in which the bone marrow fails to produce an adequate number of blood cells. There may be a lack of all cell types--white blood cells (leukocytes), red blood cells (erythrocytes), and platelets--resulting in a form of the disease called pancytopenia, or there may be a lack of...Encyclopedia Britannica, Inc., 2020
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