Disease or Syndrome
sideroblastic anemia
Subclass of:
Myelodysplastic Syndrome;
Anemia
Definitions related to sideroblastic anemia:
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A form of anemia in which the bone marrow produces ringed sideroblasts (erythrocytes in which the iron granules are arranged in ring form within the mitochondria inside the nucleus) in place of mature erythrocytes.NICHD Pediatric TerminologyU.S. National Cancer Institute, 2021
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Acquired or hereditary anemia marked by sideroblasts: bone marrow cells with large mitochondrial deposits of insoluble iron due to defective heme synthesis, leading to ineffective erythropoiesis.CRISP ThesaurusNational Institutes of Health, 2006
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Anemia characterized by the production of ringed sideroblasts instead of healthy red blood cells.NCI ThesaurusU.S. National Cancer Institute, 2021
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Sideroblastic anemia results from a defect in the incorporation of iron into the heme molecule. A sideroblast is an erythroblast that has stainable deposits of iron in cytoplasm (this can be demonstrated by Prussian blue staining).Human Phenotype Ontology (HPO)The Human Phenotype Ontology Project, 2021
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(anemia, sideroblastic) Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Sideroblastic anemias are a diverse group of anemias characterized by the presence of increased serum iron, ferritin, and transferrin saturation as well as ringed sideroblasts (erythroblasts with perinuclear iron-engorged mitochondria). Symptoms are those of anemia and include fatigue and lethargy. Diagnosis is with complete blood count,...Merck & Co., Inc., 2020
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Adult human bone marrow synthesizes 4 X 1014 molecules of hemoglobin every second. Heme and globin chains (alpha and beta) in adults are manufactured in separate cell compartments�mitochondria and cytoplasm, respectively�and then combined in cytoplasm in an amazingly accurate manner.WebMD, 2019
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Sideroblastic anemia is a group of blood disorders characterized by an impaired ability of the bone marrow to produce normal red blood cells. In this condition, the iron inside red blood cells is inadequately used to make hemoglobin, despite normal amounts of iron. As a result, iron accumulates in the red blood cells, giving a ringed...National Center for Advancing Translational Sciences
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